Search

Your search keyword '"Li, Qingsheng"' showing total 11 results
Start Over Author "Li, Qingsheng" Publisher american society for microbiology
11 results on '"Li, Qingsheng"'

2. Influenza C and D Viruses Demonstrated a Differential Respiratory Tissue Tropism in a Comparative Pathogenesis Study in Guinea Pigs

Author

Sreenivasan, Chithra C., primary, Liu, Runxia, additional, Gao, Rongyuan, additional, Guo, Yicheng, additional, Hause, Ben M., additional, Thomas, Milton, additional, Naveed, Ahsan, additional, Clement, Travis, additional, Rausch, Dana, additional, Christopher-Hennings, Jane, additional, Nelson, Eric, additional, Druce, Julian, additional, Zhao, Miaoyun, additional, Kaushik, Radhey S., additional, Li, Qingsheng, additional, Sheng, Zizhang, additional, Wang, Dan, additional, and Li, Feng, additional

Published
2023
Full Text
View/download PDF

5. Topical Tenofovir Disoproxil Fumarate Nanoparticles Prevent HIV-1 Vaginal Transmission in a Humanized Mouse Model

Author

Destache, Christopher J., primary, Mandal, Subhra, additional, Yuan, Zhe, additional, Kang, Guobin, additional, Date, Abhijit A., additional, Lu, Wuxun, additional, Shibata, Annemarie, additional, Pham, Rachel, additional, Bruck, Patrick, additional, Rezich, Michael, additional, Zhou, You, additional, Vivekanandan, Renuga, additional, Fletcher, Courtney V., additional, and Li, Qingsheng, additional

Published
2016
Full Text
View/download PDF

7. Deep Transcriptional Sequencing of Mucosal Challenge Compartment from Rhesus Macaques Acutely Infected with Simian Immunodeficiency Virus Implicates Loss of Cell Adhesion Preceding Immune Activation

Author

Barrenas, Fredrik, primary, Palermo, Robert E., additional, Agricola, Brian, additional, Agy, Michael B., additional, Aicher, Lauri, additional, Carter, Victoria, additional, Flanary, Leon, additional, Green, Richard R., additional, McLain, Randy, additional, Li, Qingsheng, additional, Lu, Wuxun, additional, Murnane, Robert, additional, Peng, Xinxia, additional, Thomas, Matthew J., additional, Weiss, Jeffrey M., additional, Anderson, David M., additional, and Katze, Michael G., additional

Published
2014
Full Text
View/download PDF

8. Replicating Adenovirus-Simian Immunodeficiency Virus (SIV) Vectors Efficiently Prime SIV-Specific Systemic and Mucosal Immune Responses by Targeting Myeloid Dendritic Cells and Persisting in Rectal Macrophages, Regardless of Immunization Route

Author

Patterson, L. Jean, primary, Kuate, Seraphin, additional, Daltabuit-Test, Mara, additional, Li, Qingsheng, additional, Xiao, Peng, additional, McKinnon, Katherine, additional, DiPasquale, Janet, additional, Cristillo, Anthony, additional, Venzon, David, additional, Haase, Ashley, additional, and Robert-Guroff, Marjorie, additional

Published
2012
Full Text
View/download PDF

10. Propagation and Dissemination of Infection after Vaginal Transmission of Simian Immunodeficiency Virus

Author

Miller, Christopher J., primary, Li, Qingsheng, additional, Abel, Kristina, additional, Kim, Eun-Young, additional, Ma, Zhong-Min, additional, Wietgrefe, Stephen, additional, La Franco-Scheuch, Lisa, additional, Compton, Lara, additional, Duan, Lijie, additional, Shore, Marta Dykhuizen, additional, Zupancic, Mary, additional, Busch, Marc, additional, Carlis, John, additional, Wolinsky, Steven, additional, and Haase, Ashley T., additional

Published
2005
Full Text
View/download PDF

11. Next-Generation mRNA Sequencing Reveals Pyroptosis-Induced CD4+ T Cell Death in Early Simian Immunodeficiency Virus-Infected Lymphoid Tissues.

Author

Lu W, Demers AJ, Ma F, Kang G, Yuan Z, Wan Y, Li Y, Xu J, Lewis M, and Li Q

Subjects
Animals, Gene Expression Profiling, High-Throughput Nucleotide Sequencing, Macaca mulatta, Male, RNA, Messenger analysis, RNA, Messenger genetics, Time Factors, CD4-Positive T-Lymphocytes physiology, CD4-Positive T-Lymphocytes virology, Lymph Nodes pathology, Pyroptosis, Simian Acquired Immunodeficiency Syndrome pathology, Simian Immunodeficiency Virus physiology
Abstract

Unlabelled: Lymphoid tissues (LTs) are the principal sites where human immunodeficiency virus type 1 (HIV-1) replicates and virus-host interactions take place, resulting in immunopathology in the form of inflammation, immune activation, and CD4(+) T cell death. The HIV-1 pathogenesis in LTs has been extensively studied; however, our understanding of the virus-host interactions in the very early stages of infection remains incomplete. We investigated virus-host interactions in the rectal draining lymph nodes (dLNs) of rhesus macaques at different times after intrarectal inoculation (days postinoculation [dpi]) with simian immunodeficiency virus (SIV). At 3 dpi, 103 differentially expressed genes (DEGs) were detected using next-generation mRNA sequencing (RNA-seq). At 6 and 10 dpi, concomitant with increased SIV replication, 366 and 1,350 DEGs were detected, respectively, including upregulation of genes encoding proteins that play a role in innate antiviral immune responses, inflammation, and immune activation. Notably, genes (IFI16, caspase-1, and interleukin 1β [IL-1β]) in the canonical pyroptosis pathway were significantly upregulated in expression. We further validated increased pyroptosis using flow cytometry and found that the number of CD4(+) T cells expressing activated caspase-1 protein, the hallmark of ongoing pyroptosis, were significantly increased, which is correlated with decreased CD4(+) T cells in dLNs. Our results demonstrated that pyroptosis contributes to the CD4(+) T cell death in vivo in early SIV infection, which suggests that pyroptosis may play a pivotal role in the pathogenesis of SIV, and by extension, that of HIV-1, since pyroptosis not only induces CD4(+) T cell death but also amplifies inflammation and immune activation. Thus, blocking CD4(+) T cell pyroptosis could be a complementary treatment to antiretroviral therapy., Importance: Although secondary lymphoid tissues (LTs) are principal sites of human immunodeficiency virus type 1 (HIV-1) replication, inflammation, immune activation, and CD4(+) T cell death, immunopathogenesis in LTs during early infection remains largely unknown. Using the simian immunodeficiency virus (SIV)/rhesus monkey model of HIV rectal infection, we investigated early virus-host interactions. Our results revealed elevated potent host responses in early infection in LTs, including upregulation of genes involved in antiviral immune response, inflammation, and immune activation. Importantly, genes involved in the canonical pyroptosis pathway were significantly upregulated, and there was a strong correlation between CD4(+) T cell decrease and increased number of CD4(+) T cells expressing activated caspase-1 protein, demonstrating that pyroptosis contributes to CD4(+) T cell death in vivo in very early SIV infection. Our finding suggests that blocking pyroptosis may be able to decrease CD4(+) T cell loss during early SIV infection., (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results