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Your search keyword '"Lyon, G. Marshall"' showing total 13 results
Start Over Author "Lyon, G. Marshall" Publisher american society for microbiology
13 results on '"Lyon, G. Marshall"'

1. Comparison of FilmArray and Quantitative Real-Time Reverse Transcriptase PCR for Detection of Zaire Ebolavirus from Contrived and Clinical Specimens

Author

Southern, Timothy R., primary, Racsa, Lori D., additional, Albariño, César G., additional, Fey, Paul D., additional, Hinrichs, Steven H., additional, Murphy, Caitlin N., additional, Herrera, Vicki L., additional, Sambol, Anthony R., additional, Hill, Charles E., additional, Ryan, Emily L., additional, Kraft, Colleen S., additional, Campbell, Shelley, additional, Sealy, Tara K., additional, Schuh, Amy, additional, Ritchie, James C., additional, Lyon, G. Marshall, additional, Mehta, Aneesh K., additional, Varkey, Jay B., additional, Ribner, Bruce S., additional, Brantly, Kent P., additional, Ströher, Ute, additional, Iwen, Peter C., additional, and Burd, Eileen M., additional

Published
2015
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2. Serological Correlates of Protection against a GII.4 Norovirus

Author

Atmar, Robert L., primary, Bernstein, David I., additional, Lyon, G. Marshall, additional, Treanor, John J., additional, Al-Ibrahim, Mohamed S., additional, Graham, David Y., additional, Vinjé, Jan, additional, Jiang, Xi, additional, Gregoricus, Nicole, additional, Frenck, Robert W., additional, Moe, Christine L., additional, Chen, Wilbur H., additional, Ferreira, Jennifer, additional, Barrett, Jill, additional, Opekun, Antone R., additional, Estes, Mary K., additional, Borkowski, Astrid, additional, Baehner, Frank, additional, Goodwin, Robert, additional, Edmonds, Anthony, additional, and Mendelman, Paul M., additional

Published
2015
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3. Reply to “Insufficient Demonstration of Long-Term Stability of Aspergillus Galactomannan”

Author

Wheat, L. Joseph, primary, Nguyen, M. Hong, additional, Alexander, Barbara D., additional, Denning, David, additional, Caliendo, Angela M., additional, Lyon, G. Marshall, additional, Baden, Lindsey R., additional, Marty, Francisco M., additional, Clancy, Cornelius, additional, Kirsch, Emily, additional, Noth, Pamela, additional, Witt, John, additional, Sugrue, Michele, additional, and Wingard, John R., additional

Published
2014
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4. Long-Term Stability at −20°C of Aspergillus Galactomannan in Serum and Bronchoalveolar Lavage Specimens

Author

Wheat, L. Joseph, primary, Nguyen, M. Hong, additional, Alexander, Barbara D., additional, Denning, David, additional, Caliendo, Angela M., additional, Lyon, G. Marshall, additional, Baden, Lindsey R., additional, Marty, Francisco M., additional, Clancy, Cornelius, additional, Kirsch, Emily, additional, Noth, Pamela, additional, Witt, John, additional, Sugrue, Michele, additional, and Wingard, John R., additional

Published
2014
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6. Norovirus Infectivity in Humans and Persistence in Water

Author

Seitz, Scot R., primary, Leon, Juan S., additional, Schwab, Kellogg J., additional, Lyon, G. Marshall, additional, Dowd, Melissa, additional, McDaniels, Marisa, additional, Abdulhafid, Gwen, additional, Fernandez, Marina L., additional, Lindesmith, Lisa C., additional, Baric, Ralph S., additional, and Moe, Christine L., additional

Published
2011
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7. Randomized, Double-Blinded Clinical Trial for Human Norovirus Inactivation in Oysters by High Hydrostatic Pressure Processing

Author

Leon, Juan S., primary, Kingsley, David H., additional, Montes, Julia S., additional, Richards, Gary P., additional, Lyon, G. Marshall, additional, Abdulhafid, Gwen M., additional, Seitz, Scot R., additional, Fernandez, Marina L., additional, Teunis, Peter F., additional, Flick, George J., additional, and Moe, Christine L., additional

Published
2011
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9. Calcineurin Inhibitor Agents Interact Synergistically with Antifungal Agents In Vitro against Cryptococcus neoformans Isolates: Correlation with Outcome in Solid Organ Transplant Recipients with Cryptococcosis

Author

Kontoyiannis, Dimitrios P., primary, Lewis, Russell E., additional, Alexander, Barbara D., additional, Lortholary, Olivier, additional, Dromer, Françoise, additional, Gupta, Krishan L., additional, John, George T., additional, del Busto, Ramon, additional, Klintmalm, Goran B., additional, Somani, Jyoti, additional, Lyon, G. Marshall, additional, Pursell, Kenneth, additional, Stosor, Valentina, additional, Muňoz, Patricia, additional, Limaye, Ajit P., additional, Kalil, Andre C., additional, Pruett, Timothy L., additional, Garcia-Diaz, Julia, additional, Humar, Atul, additional, Houston, Sally, additional, House, Andrew A., additional, Wray, Dannah, additional, Orloff, Susan, additional, Dowdy, Lorraine A., additional, Fisher, Robert A., additional, Heitman, Joseph, additional, Albert, Nathaniel D., additional, Wagener, Marilyn M., additional, and Singh, Nina, additional

Published
2008
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10. Incidence of Bloodstream Infections Due to Candida Species and In Vitro Susceptibilities of Isolates Collected from 1998 to 2000 in a Population-Based Active Surveillance Program

Author

Hajjeh, Rana A., primary, Sofair, Andre N., additional, Harrison, Lee H., additional, Lyon, G. Marshall, additional, Arthington-Skaggs, Beth A., additional, Mirza, Sara A., additional, Phelan, Maureen, additional, Morgan, Juliette, additional, Lee-Yang, Wendy, additional, Ciblak, Meral A., additional, Benjamin, Lynette E., additional, Thomson Sanza, Laurie, additional, Huie, Sharon, additional, Yeo, Siew Fah, additional, Brandt, Mary E., additional, and Warnock, David W., additional

Published
2004
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11. Influenza virus infection and aerosol shedding kinetics in a controlled human infection model.

Author

Shetty N, Shephard MJ, Rockey NC, Macenczak H, Traenkner J, Danzy S, Vargas-Maldonado N, Arts PJ, Le Sage V, Anderson EJ, Lyon GM, Fitts EC, Gulick DA, Mehta AK, El-Chami MF, Kraft CS, Wigginton KR, Lowen AC, Marr LC, Rouphael NG, and Lakdawala SS

Abstract

Establishing effective mitigation strategies to reduce the spread of influenza virus requires an improved understanding of the mechanisms of transmission. We evaluated the use of a controlled human infection model using an H3N2 seasonal influenza virus to study critical aspects of transmission, including symptom progression and the dynamics of virus shedding. Eight volunteers were challenged with influenza A/Perth/16/2009 (H3N2) virus between July and September 2022 at Emory University Hospital. Viral shedding in the nasopharynx, saliva, stool, urine, and respiratory aerosols was monitored over the quarantine period, and symptoms were tracked until day 15. In addition, environmental swabs were collected from participant rooms to examine fomite contamination, and participant sera were collected to assess seroconversion by hemagglutination inhibition or microneutralization assays. Among the eight participants, influenza virus infection was confirmed in six (75%). Infectious virus or viral RNA was found in multiple physiological compartments, fecal samples, aerosol particles, and on surfaces in the immediate environment. Illness was moderate, with upper respiratory symptoms dominating. In participants with the highest viral loads, antibody titers rose by day 15 post-inoculation, while in participants with low or undetectable viral loads, there was little or no increase in functional antibody titers. These data demonstrate the safety and utility of the human infection model to study features critical to influenza virus transmission dynamics in a controlled manner and will inform the design of future challenge studies focused on modeling and limiting transmission.CLINICAL TRIALSThis study is registered with ClinicalTrials.gov as NCT05332899., Importance: We use a controlled human infection model to assess respiratory and aerosol shedding kinetics to expand our knowledge of influenza infection dynamics and help inform future studies aimed at understanding human-to-human transmission.

Published
2024
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12. Long-term stability at -20 °C of Aspergillus galactomannan in serum and bronchoalveolar lavage specimens.

Author

Wheat LJ, Nguyen MH, Alexander BD, Denning D, Caliendo AM, Lyon GM, Baden LR, Marty FM, Clancy C, Kirsch E, Noth P, Witt J, Sugrue M, and Wingard JR

Subjects
Galactose analogs & derivatives, Humans, Immunoenzyme Techniques methods, Time Factors, Aspergillosis diagnosis, Aspergillus isolation & purification, Bronchoalveolar Lavage Fluid chemistry, Freezing, Mannans analysis, Serum chemistry, Specimen Handling methods
Abstract

Research to develop and validate novel methods for diagnosis of aspergillosis based on detection of galactomannan requires the use of clinical specimens that have been stored frozen. Data indicating that galactomannan remains stable when frozen are scant. The objective of this study was to determine the stability of galactomannan in clinical specimens stored at -20 °C that were positive in the Platelia Aspergillus enzyme immunoassay when initially tested. Prospective real-time testing of serum and bronchoalveolar lavage (BAL) fluid pools from positive and negative patient specimens showed no decline in galactomannan index (GMI) over 11 months at -20 °C and no development of positive reactions in the negative-control pool. Retrospective testing of positive specimens that had been stored at -20 °C for 5 years showed that 28 of 30 serum (n = 15) or BAL (n = 15) specimens remained positive. These findings support the use of frozen serum or BAL specimens stored for at least 5 years in evaluation of diagnostic tests based on detection of galactomannan., (Copyright © 2014, American Society for Microbiology. All Rights Reserved.)

Published
2014
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13. Development and evaluation of a calibrator material for nucleic acid-based assays for diagnosing aspergillosis.

Author

Lyon GM, Abdul-Ali D, Loeffler J, White PL, Wickes B, Herrera ML, Alexander BD, Baden LR, Clancy C, Denning D, Nguyen MH, Sugrue M, Wheat LJ, Wingard JR, Donnelly JP, Barnes R, Patterson TF, and Caliendo AM

Subjects
Humans, Microbiological Techniques methods, Molecular Diagnostic Techniques methods, Aspergillosis diagnosis, Aspergillus genetics, DNA, Fungal genetics, Microbiological Techniques standards, Molecular Diagnostic Techniques standards, Reference Standards
Abstract

Twelve laboratories evaluated candidate material for an Aspergillus DNA calibrator. The DNA material was quantified using limiting-dilution analysis; the mean concentration was determined to be 1.73 × 10(10) units/ml. The calibrator can be used to standardize aspergillosis diagnostic assays which detect and/or quantify nucleic acid.

Published
2013
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