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Start Over Author "Munk M" Publisher american society for microbiology
7 results on '"Munk M"'

6. Increased numbers of ESAT-6- and purified protein derivative-specific gamma interferon-producing cells in subclinical and active tuberculosis infection.

Author

Ulrichs T, Anding P, Porcelli S, Kaufmann SH, and Munk ME

Subjects
Amino Acid Sequence, Antigens, Bacterial chemistry, Antigens, Bacterial genetics, BCG Vaccine, Bacterial Proteins, Enzyme-Linked Immunosorbent Assay methods, Humans, Leukocytes, Mononuclear immunology, Molecular Sequence Data, Tuberculosis, Pulmonary immunology, Vaccination, Antigens, Bacterial immunology, Interferon-gamma biosynthesis, Mycobacterium tuberculosis immunology, Tuberculin immunology, Tuberculosis, Pulmonary diagnosis
Abstract

Numbers of gamma interferon (IFN-gamma)-producing cells reactive to ESAT-6 antigen were increased in recent converters to purified protein derivative positivity and in tuberculosis patients but not in unvaccinated or Mycobacterium bovis BCG-vaccinated healthy donors. ESAT-6-reactive IFN-gamma-producing cells in recent converters and tuberculosis patients recognized similar synthetic peptides. Thus, ESAT-6 is a potential candidate for use in detection of early, as well as active, tuberculosis and for control of the disease.

Published
2000
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7. Soluble tumor necrosis factor alpha receptors in sera from leprosy patients.

Author

Munk ME, Anding P, Schettini AP, Cunha MG, and Kaufmann SH

Subjects
Adult, Animals, Antigens, CD physiology, Cytotoxicity Tests, Immunologic, Female, Humans, Leprosy drug therapy, Leprosy immunology, Leprosy, Tuberculoid blood, Leprosy, Tuberculoid drug therapy, Leprosy, Tuberculoid immunology, Male, Mice, Receptors, Tumor Necrosis Factor physiology, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Solubility, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha antagonists & inhibitors, Antigens, CD blood, Leprosy blood, Receptors, Tumor Necrosis Factor blood
Abstract

Serum levels of soluble tumor necrosis factor alpha receptor I (sTNF-RI) were elevated in patients with lepromatous (LL) reactional-state type II leprosy, and sTNF-RII levels were increased in patients with full tuberculoid (TT) or LL type II leprosy. The sTNF-R in sera from patients with type II leprosy, but not other forms of leprosy, inhibited recombinant TNF cytolytic activities in vitro. This suggests that sTNF-R regulatory activities are partially impaired in patients with leprosy.

Published
1999
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