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Your search keyword '"Park, Man-Seong"' showing total 11 results
Start Over Author "Park, Man-Seong" Publisher american society for microbiology
11 results on '"Park, Man-Seong"'

1. Novel Small Molecule Targeting the Hemagglutinin Stalk of Influenza Viruses

Author

Kim, Jin Il, primary, Lee, Sangmoo, additional, Lee, Gong Yeal, additional, Park, Sehee, additional, Bae, Joon-Yong, additional, Heo, Jun, additional, Kim, Hong-Youb, additional, Woo, Seok-Hun, additional, Lee, Hae Un, additional, Ahn, Chung Am, additional, Bang, Hye Jin, additional, Ju, Hyun Soo, additional, Ok, Kiwon, additional, Byun, Youngjoo, additional, Cho, Dae-Jin, additional, Shin, Jae Soo, additional, Kim, Dong-Yeon, additional, Park, Mee Sook, additional, and Park, Man-Seong, additional

Published
2019
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10. Recombinant Newcastle Disease Virus as a Vaccine Vector

Author

Nakaya, Takaaki, primary, Cros, Jerome, additional, Park, Man-Seong, additional, Nakaya, Yurie, additional, Zheng, Hongyong, additional, Sagrera, Ana, additional, Villar, Enrique, additional, Garcı́a-Sastre, Adolfo, additional, and Palese, Peter, additional

Published
2001
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11. Expression of Transgenes from Newcastle Disease Virus with a Segmented Genome.

Author

Qinshan Gao, Park, Man-Seong, and Palese, Peter

Subjects
*PARAMYXOVIRUSES, *TRANSGENES, *NEWCASTLE disease virus, *GENOMES, *GREEN fluorescent protein
Abstract

Paramyxoviruses belong to the Paramyxoviridae family of the order Mononegavirales. They have a nonsegmented negative-stranded RNA genome and can cause a number of diseases in humans and animals. We generated a recombinant Newcastle disease virus (NDV) possessing a two-segmented genome. Each genomic segment is flanked by authentic NDV 3' and 5' noncoding termini allowing for efficient replication and transcription. A reporter gene encoding green fluorescent protein (GFP) was inserted into one segment, and a red fluorescent protein dsRed gene was inserted into the other segment in order to easily detect the replication and transcription of segments in infected cells. The rescued viruses grew well and were stable in embryonated chicken eggs over multiple passages. We were able to detect the expression of both reporter genes in the same cell infected with the virus possessing a segmented genome, and viral particles can contain either one or two types of RNA segments. We also rescued a two-segmented virus expressing GFP and the severe acute respiratory syndrome-associated coronavirus spike S protein, which is about 200 kDa. The chimeric virus extends the coding capacity of NDV by 30%, suggesting that the two-segmented NDV can be used for development of vaccines or gene therapy vectors carrying long and multiple transgenes. [ABSTRACT FROM AUTHOR]

Published
2008
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