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Your search keyword '"Severini, Carlo"' showing total 6 results
Start Over Author "Severini, Carlo" Publisher american society for microbiology
6 results on '"Severini, Carlo"'

2. A Quality Control Program within a Clinical Trial Consortium for PCR Protocols To Detect Plasmodium Species

Author

Taylor, Steve M., primary, Mayor, Alfredo, additional, Mombo-Ngoma, Ghyslain, additional, Kenguele, Hilaire M., additional, Ouédraogo, Smaïla, additional, Ndam, Nicaise Tuikue, additional, Mkali, Happy, additional, Mwangoka, Grace, additional, Valecha, Neena, additional, Singh, Jai Prakash Narayan, additional, Clark, Martha A., additional, Verweij, Jaco J., additional, Adegnika, Ayola Akim, additional, Severini, Carlo, additional, Menegon, Michela, additional, Macete, Eusebio, additional, Menendez, Clara, additional, Cisteró, Pau, additional, Njie, Fanta, additional, Affara, Muna, additional, Otieno, Kephas, additional, Kariuki, Simon, additional, ter Kuile, Feiko O., additional, and Meshnick, Steven R., additional

Published
2014
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3. Modulation of the Immune and Inflammatory Responses by Plasmodium falciparum Schizont Extracts: Role of Myeloid Dendritic Cells in Effector and Regulatory Functions of CD4 + Lymphocytes

Author

Clemente, Ann Maria, primary, Fadigati, Giulia, additional, Caporale, Roberto, additional, Marchese, Damiano G., additional, Castronovo, Giuseppe, additional, Sannella, Anna Rosa, additional, Severini, Carlo, additional, Verra, Federica, additional, Garaci, Enrico, additional, Cozzolino, Federico, additional, and Torcia, Maria Gabriella, additional

Published
2013
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4. Genetic Confirmation of Quinine-Resistant Plasmodium falciparum Malaria Followed by Postmalaria Neurological Syndrome in a Traveler from Mozambique

Author

Palmieri, Fabrizio, primary, Petrosillo, Nicola, additional, Paglia, Maria Grazia, additional, Conte, Aristide, additional, Goletti, Delia, additional, Pucillo, Leopoldo Paolo, additional, Menegon, Michela, additional, Sannella, Anna, additional, Severini, Carlo, additional, and Majori, Giancarlo, additional

Published
2004
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6. Modulation of the immune and inflammatory responses by Plasmodium falciparum schizont extracts: role of myeloid dendritic cells in effector and regulatory functions of CD4+ lymphocytes.

Author

Clemente AM, Fadigati G, Caporale R, Marchese DG, Castronovo G, Sannella AR, Severini C, Verra F, Garaci E, Cozzolino F, and Torcia MG

Subjects
Cell Differentiation immunology, Cytokines metabolism, T-Lymphocytes, Regulatory immunology, T-Lymphocytes, Regulatory metabolism, Dendritic Cells immunology, Inflammation immunology, Myeloid Cells immunology, Plasmodium falciparum immunology, T-Lymphocytes, Regulatory parasitology
Abstract

The optimal immune response to malaria infection comprises rapid induction of inflammatory responses promptly counteracted by regulatory mechanisms to prevent immunopathology. To evaluate the role of dendritic cells (DC) in the balance of parasite-induced inflammatory/anti-inflammatory mechanisms, we studied the activity of monocyte-derived dendritic cells (MDDC), previously exposed to soluble extracts of Plasmodium falciparum-infected red blood cells (PfSE), in the differentiation of CD4 cells isolated from donors never exposed to malaria infection. We show that MDDC exposed to PfSE are extremely efficient to induce a contemporary differentiation of TH1 effector cells and T regulatory (Treg) cells in CD4 T cells even when exposed to low concentrations of parasitic extracts. Treg cells induced by MDDC infected with PfSE (MDDC-PfSE) produce transforming growth factor beta (TGF-β) and interleukin 10 (IL-10) and are endowed with strong suppressive properties. They also show phenotypical and functional peculiarities, such as the contemporary expression of markers of Treg and TH1 differentiation and higher sensitivity to TLR4 ligands both inducing an increasing production of suppressive cytokines. On the whole, our data indicate that MDDC exposed to PfSE orchestrate a well-balanced immune response with timely differentiation of TH1 and Treg cells in CD4 cells from nonimmune donors and suggest that, during the infection, the role of MDCC could be particularly relevant in low-parasitemia conditions.

Published
2013
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