1. Combat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics
- Author
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Carmita Sanders, Nathan P. Wiederhold, Anuradha Ganesan, Ian R Driscoll, Elizabeth A Rini, Brent Enniss, Todd J. Vento, James Feig, Deanna A. Sutton, Clinton K. Murray, Katrin Mende, Aaron R. Farmer, and Brian L. Wickes
- Subjects
Adult ,Male ,Microbiology (medical) ,Pathology ,medicine.medical_specialty ,Lichtheimia corymbifera ,Pythium ,Case Reports ,Bombs ,Microbiology ,Young Adult ,Pythiosis ,Fatal Outcome ,Blast Injuries ,medicine ,Humans ,Pythium aphanidermatum ,biology ,food and beverages ,Saksenaea vasiformis ,biology.organism_classification ,Molecular diagnostics ,medicine.disease ,Military Personnel ,Molecular Diagnostic Techniques ,Wound Infection ,Coinfection ,Total body surface area - Abstract
We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence- and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans , Lichtheimia corymbifera , and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.
- Published
- 2015
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