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Your search keyword '"Uchiyama, Satoshi"' showing total 10 results
Start Over Author "Uchiyama, Satoshi" Publisher american society for microbiology
10 results on '"Uchiyama, Satoshi"'

1. Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins

Author

Hirose, Yujiro, primary, Poudel, Saugat, additional, Sastry, Anand V., additional, Rychel, Kevin, additional, Lamoureux, Cameron R., additional, Szubin, Richard, additional, Zielinski, Daniel C., additional, Lim, Hyun Gyu, additional, Menon, Nitasha D., additional, Bergsten, Helena, additional, Uchiyama, Satoshi, additional, Hanada, Tomoki, additional, Kawabata, Shigetada, additional, Palsson, Bernhard O., additional, and Nizet, Victor, additional

Published
2023
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3. Virulence role of the glcnac side chain of the lancefield cell wall carbohydrate antigen in non-m1-serotype group a streptococcus

Author

MMB Moleculair B, Infection & Immunity, Henningham, Anna, Davies, Mark R., Uchiyama, Satoshi, Van Sorge, Nina M., Lund, Sean, Chen, Kelsey T., Walker, Mark J., Cole, Jason N., Nizet, Victor, MMB Moleculair B, Infection & Immunity, Henningham, Anna, Davies, Mark R., Uchiyama, Satoshi, Van Sorge, Nina M., Lund, Sean, Chen, Kelsey T., Walker, Mark J., Cole, Jason N., and Nizet, Victor

Published
2018

6. Serine aspartate repeat protein D increases Staphylococcus aureus virulence and survival in blood

Author

MMB, UMC Utrecht, Infection & Immunity, Askarian, Fatemeh, Uchiyama, Satoshi, Valderrama, J. Andrés, Ajayi, Clement, Sollid, Johanna U E, van Sorge, Nina M., Nizet, Victor, van Strijp, Jos A G, Johannessen, Mona, MMB, UMC Utrecht, Infection & Immunity, Askarian, Fatemeh, Uchiyama, Satoshi, Valderrama, J. Andrés, Ajayi, Clement, Sollid, Johanna U E, van Sorge, Nina M., Nizet, Victor, van Strijp, Jos A G, and Johannessen, Mona

Published
2017

10. Serine-Aspartate Repeat Protein D Increases Staphylococcus aureus Virulence and Survival in Blood.

Author

Askarian F, Uchiyama S, Valderrama JA, Ajayi C, Sollid JUE, van Sorge NM, Nizet V, van Strijp JAG, and Johannessen M

Subjects
Adhesins, Bacterial metabolism, Animals, Bacterial Adhesion physiology, Female, Humans, Immunity, Innate immunology, Lactococcus lactis immunology, Lactococcus lactis metabolism, Mice, Neutrophils immunology, Neutrophils metabolism, Neutrophils microbiology, Recombinant Proteins metabolism, Staphylococcal Infections immunology, Staphylococcus aureus immunology, Virulence immunology, Bacterial Proteins metabolism, Calcium-Binding Proteins metabolism, Staphylococcal Infections blood, Staphylococcal Infections microbiology, Staphylococcus aureus metabolism, Staphylococcus aureus pathogenicity, Virulence physiology
Abstract

Staphylococcus aureus expresses a panel of cell wall-anchored adhesins, including proteins belonging to the microbial surface components recognizing adhesive matrix molecule (MSCRAMM) family, exemplified by the serine-aspartate repeat protein D (SdrD), which serve key roles in colonization and infection. Deletion of sdrD from S. aureus subsp. aureus strain NCTC8325-4 attenuated bacterial survival in human whole blood ex vivo, which was associated with increased killing by human neutrophils. Remarkably, SdrD was able to inhibit innate immune-mediated bacterial killing independently of other S. aureus proteins, since addition of recombinant SdrD protein and heterologous expression of SdrD in Lactococcus lactis promoted bacterial survival in human blood. SdrD contributes to bacterial virulence in vivo, since fewer S. aureus subsp. aureus NCTC8325-4 ΔsdrD bacteria than bacteria of the parent strain were recovered from blood and several organs using a murine intravenous infection model. Collectively, our findings reveal a new property of SdrD as an important key contributor to S. aureus survival and the ability to escape the innate immune system in blood., (Copyright © 2016 Askarian et al.)

Published
2016
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