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Your search keyword '"Wagner, Valentina"' showing total 6 results
Start Over Author "Wagner, Valentina" Publisher american society for microbiology
6 results on '"Wagner, Valentina"'

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3. Human MxB Protein Is a Pan-herpesvirus Restriction Factor

Author

Schilling, Mirjam, primary, Bulli, Lorenzo, additional, Weigang, Sebastian, additional, Graf, Laura, additional, Naumann, Sebastian, additional, Patzina, Corinna, additional, Wagner, Valentina, additional, Bauersfeld, Liane, additional, Goujon, Caroline, additional, Hengel, Hartmut, additional, Halenius, Anne, additional, Ruzsics, Zsolt, additional, Schaller, Torsten, additional, and Kochs, Georg, additional more...

Published
2018
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6. In Vivo Conditions Enable IFNAR-Independent Type I Interferon Production by Peritoneal CD11b+ Cells upon Thogoto Virus Infection.

Author

Kochs, Georg, Anzaghe, Martina, Kronhart, Stefanie, Wagner, Valentina, Gogesch, Patricia, Scheu, Stefanie, Lienenklaus, Stefan, and Waibler, Zoe

Subjects
*INTERFERONS, *VIRUS diseases, *EMBRYOLOGY, *ORTHOMYXOVIRUS infections, *POLYMERASE chain reaction
Abstract

Type I interferons (IFNs) crucially contribute to host survival upon viral infections. Robust expression of type I IFNs (IFN-α/β) and induction of an antiviral state critically depend on amplification of the IFN signal via the type I IFN receptor (IFNAR). A small amount of type I IFN produced early upon virus infection binds the IFNAR and activates a self-enhancing positive feedback loop, resulting in induction of large, protective amounts of IFN-α. Unexpectedly, we found robust, systemic IFN-α expression upon infection of IFNAR knockout mice with the orthomyxovirus Thogoto virus (THOV). The IFNAR-independent IFN-α production required in vivo conditions and was not achieved during in vitro infection. Using replication-incompetent THOVderived virus-like particles, we demonstrate that IFNAR-independent type I IFN induction depends on viral polymerase activity but is largely independent of viral replication. To discover the cell type responsible for this effect, we used type I IFN reporter mice and identified CD11b+ F4/80+ myeloid cells within the peritoneal cavity of infected animals as the main source of IFNARindependent type I IFN, corresponding to the particular tropism of THOV for this cell type. [ABSTRACT FROM AUTHOR] more...

Published
2016
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