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Start Over Author "Whiteway, J." Publisher american society for microbiology
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1. Oxygen-insensitive nitroreductases: analysis of the roles of nfsA and nfsB in development of resistance to 5-nitrofuran derivatives in Escherichia coli

Author

Whiteway, J., Koziarz, P., Veall, J., Sandhu, N., Kumar, P., Hoecher, B., and Lambert, I.B.

Subjects
Drug resistance in microorganisms -- Research, Escherichia coli -- Genetic aspects, Gene mutations -- Research, Biological sciences
Abstract

Research was conducted to examine the roles of nfsA and nfsB genes in the development of resistance to 5-nitrofuran derivatives in Escherichia coli. The nfsA and nfsB genes of a large number of nitrofuran-resistant mutants of E coli were characterized and mutation was correlated with cell extract nitroreductase activity. Results provided evidence that an nfsA mutation was responsible for the first-step resistance to furazolidone or nitrofurazone while an nfsB mutation was responsible for increased resistance related to second-step mutants.

Published
1998

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