1. The Caspofungin Paradoxical Effect is a Tolerant 'Eagle Effect' in the Filamentous Fungal Pathogen Aspergillus fumigatus
- Author
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Clara Valero, Ana Cristina Colabardini, Patrícia Alves de Castro, Jorge Amich, Michael J. Bromley, Gustavo H. Goldman, Wellcome Trust, São Paulo Research Foundation, National Council for Scientific and Technological Development (Brasil), and NIH - National Institute of Allergy and Infectious Diseases (NIAID) (Estados Unidos)
- Subjects
Antifungal Agents ,Aspergillus fumigatus ,Eagles ,Microbial Sensitivity Tests ,Spores, Fungal ,Microbiology ,Fungal Proteins ,Echinocandins ,Caspofungin ,Virology ,Animals ,Eagle effect ,Drug heterogeneity ,Tolerance - Abstract
Cell responses against antifungals other than resistance have rarely been studied in filamentous fungi, while terms such as tolerance and persistence are well-described for bacteria and increasingly examined in yeast-like organisms. Aspergillus fumigatus is a filamentous fungal pathogen that causes a disease named aspergillosis, for which caspofungin (CAS), a fungistatic drug, is used as a second-line therapy. Some A. fumigatus clinical isolates can survive and grow in CAS concentrations above the minimum effective concentration (MEC), a phenomenon known as "caspofungin paradoxical effect" (CPE). Here, we evaluated the CPE in 67 A. fumigatus clinical isolates by calculating recovery rate (RR) values, where isolates with an RR of ≥0.1 were considered CPE+ while isolates with an RR of
- Published
- 2022