1. Association of serum nā6 and nā3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men123
- Author
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Motoyama, Kenneth R, Curb, J David, Kadowaki, Takashi, El-Saed, Aiman, Abbott, Robert D, Okamura, Tomonori, Evans, Rhobert W, Nakamura, Yasuyuki, Sutton-Tyrrell, Kim, Rodriquez, Beatriz L, Kadota, Aya, Edmundowicz, Daniel, Willcox, Bradley J, Choo, Jina, Katsumi, Nakata, Otake, Teruo, Kadowaki, Sayaka, Kuller, Lewis H, Ueshima, Hirotusgu, and Sekikawa, Akira
- Subjects
Adult ,Alcohol Drinking ,Cholesterol, HDL ,Smoking ,food and beverages ,Fasting ,Middle Aged ,Pennsylvania ,Lipids ,eye diseases ,United States ,White People ,Cross-Sectional Studies ,Asian People ,Japan ,Fatty Acids, Omega-6 ,Surveys and Questionnaires ,Fatty Acids, Omega-3 ,Humans ,lipids (amino acids, peptides, and proteins) ,sense organs ,human activities ,Life Style ,Triglycerides - Abstract
The association of serum polyunsaturated fatty acids (PUFAs) with lipids in different populations is not known.Our aim was to examine the association of serum n-6 (omega-6) or n-3 (omega-3) PUFAs with triglycerides or HDL-cholesterol concentrations in 261 white, 285 Japanese, and 212 Japanese American men aged 40-49 y.We used a population-based cross-sectional study. Of the original sample (n = 926), those taking lipid-lowering medications or who had diabetes (n = 168) were excluded. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Multiple regression models as a function of tertile groups of each PUFA were used.Serum n-6 PUFAs were significantly inversely associated with triglycerides across populations after adjustment for age, body mass index, pack-years of smoking, and ethanol consumption [beta = -0.39 (P0.001), -0.38 (P0.001), and -0.33 (P0.001) in whites, Japanese, and Japanese Americans, respectively]. Marine n-3 PUFAs were significantly inversely associated with triglycerides across populations [beta = -0.15 (P0.001), -0.22 (P0.001), and -0.13 (P0.001) in whites, Japanese, and Japanese Americans, respectively]. n-6 PUFAs were significantly positively associated with HDL cholesterol in whites (beta = 4.49, P0.001) and Japanese (beta = 3.73, P0.01). Marine n-3 PUFAs were significantly positively associated with HDL cholesterol in Japanese (beta = 2.15, P0.05), and eicosapentaenoic acid was significantly positively associated with HDL cholesterol in whites (beta = 2.68, P0.01).Serum n-6 and n-3 PUFAs are inversely associated with triglycerides across populations.
- Published
- 2009