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Soft-tissue sarcomas represent around 1% of diagnosed cancers worldwide, with liposarcomas (LPSs) making up 20% of those cases.[1] Well-differentiated/dedifferentiated LPS (WD/DDLPS) represents the largest subset and are identified on the basis of the presence of I MDM2 i and I CDK4 i amplifications.[2] Treatment depends largely on complete surgical resection as these tumors are typically not responsive to chemotherapy, with only about 15%-20% of patients having an objective response.[3] However, despite surgical treatment, up to 80% of patients with retroperitoneal LPS will experience regional recurrence and 30% of DDLPS will a have metastatic spread, raising the need for more effective treatments.[4],[5] Cyclin-dependent kinases (CDKs) are cell cycle regulatory proteins that work by phosphorylating the retinoblastoma (Rb) protein and drive cell cycle progression from the G1 to S phase.[6] CDK dysregulation leads to hyperproliferation and uncontrolled cell growth. He remained tumor free until May 2020 when a follow-up CT scan of the abdomen/pelvis revealed a new left-sided paraspinal mass abutting the psoas muscle (2.2 × 1.6 cm) and a mesenteric (2.1 × 2.8 cm) mass, consistent with recurrence of disease (Fig 1). He underwent neoadjuvant treatment with two cycles of doxorubicin/dacarbazine with interval progression of the tumor on CT imaging, followed by surgical resection. Given that WD/DDLPS are complex tumors with multiple chromosomal abnormalities, targeting one pathway may not adequately treat all tumors. [Extracted from the article]

The article reports on the experience of a multidisciplinary Molecular Tumor Board in 2015 that examined breast cancer patients whose tumors underwent genomic profiling. Results show that there was at least one actionable aberration in 40 of 43 patients, and that 17 were treated based on discussions, with 7 achieving stability or partial remission for 6 or more months. It also states that boards may optimize management of such patients and that targeted drugs should be made available.