1. Quality of Life During Chemotherapy for Breast Cancer in a West African Population in Dakar, Senegal: A Prospective Study
- Author
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Mamadou Diop, Papa Massamba Diene, Ahmadou Dem, Anthony Gonçalves, Mouhamadou Ba, Audrey Monneur, Pierre Annede, Domitille Dano, Ousseynou Sarr, Ibrahima Thiam, Patricia Marino, Awa Sadikh Badiane, Kanta Ka, Doudou Diouf, Julien Mancini, Clémence Hénon, Dupuis, Christine, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut Gustave Roussy (IGR), Biomarqueurs prédictifs et nouvelles stratégies moléculaires en thérapeutique anticancéreuse (U981), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aristide Le Dantec Hospital [Dakar, Senegal], Aix Marseille Université (AMU), and Hôpital de la Timone [CHU - APHM] (TIMONE)
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Cancer Research ,Pediatrics ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,MESH: Nausea ,MESH: Linear Models ,0302 clinical medicine ,Quality of life ,MESH: Vomiting ,Surveys and Questionnaires ,Original Report ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,MESH: Treatment Outcome ,education.field_of_study ,MESH: Middle Aged ,Nausea ,MESH: Neoplasm Staging ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Senegal ,3. Good health ,[SDV] Life Sciences [q-bio] ,West african ,Treatment Outcome ,Oncology ,030220 oncology & carcinogenesis ,Female ,Adult ,medicine.medical_specialty ,Vomiting ,Population ,MEDLINE ,Antineoplastic Agents ,Breast Neoplasms ,lcsh:RC254-282 ,03 medical and health sciences ,MESH: Drug Therapy ,Breast cancer ,Drug Therapy ,MESH: Senegal ,medicine ,Humans ,MESH: Surveys and Questionnaires ,education ,Neoplasm Staging ,Chemotherapy ,MESH: Humans ,business.industry ,MESH: Quality of Life ,MESH: Adult ,medicine.disease ,MESH: Prospective Studies ,Linear Models ,Quality of Life ,MESH: Antineoplastic Agents ,Neoplasm staging ,business ,MESH: Female ,MESH: Breast Neoplasms - Abstract
PURPOSE The prevalence of breast cancer is increasing in low- to middle-income countries such as Senegal. Our prospective study assessed the quality of life (QoL) of patients with breast cancer undergoing chemotherapy in Senegal. PATIENTS AND METHODS Our study included women with breast cancer undergoing chemotherapy as initial treatment at the Center Aristide Le Dantec University Hospital in Dakar. Clinical, sociodemographic, and QoL data were collected and analyzed at three different times: baseline, 3 months, and 6 months after the start of systemic therapy. Health-related QoL was assessed using a Functional Assessment of Cancer Therapies-Breast (FACT-B) questionnaire after translation into the Wolof language. Linear mixed-effects models were performed to assess the changes in QoL scores. RESULTS Between July 2017 and February 2018, 120 patients were included in the study. Their median age was 45 years. Most patients (n = 105; 92%) had locally advanced disease (T3 to T4 stage) and lymph node involvement (n = 103; 88%), and half had metastatic disease. The FACT-B total scores significantly improved over time (β = 1.58; 95% CI, 0.50 to 2.67; P < .01). Nausea and vomiting were significantly associated with a decrease in FACT-B total scores (β = −16.89, 95% CI, −29.58 to −4.24, P = .012; and β = −13.44, 95% CI, −25.15 to −1.72, P = .028, respectively). CONCLUSION Our study confirmed the feasibility of standardized QoL assessment in Senegalese patients with breast cancer. Our results indicated a potential improvement of QoL over the course of chemotherapy. Optimizing nausea and vomiting prevention may improve QoL.
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- 2019