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Start Over Author "Kienan Savage" Publisher american society of clinical oncology (asco)
1 results on '"Kienan Savage"'

1. The effect of PARP inhibition on BAX/BAK independent synthetic lethality of BRCA1-deficient non-small cell lung cancer

Author

Derek J. Richard, Kenneth J. O'Byrne, Kienan Savage, Michael Sheaff, Jacqueline James, Jennifer E. Quinn, Kathy Gately, Jaine K. Blayney, Dean A. Fennell, Ian M. Paul, Peter W. Hamilton, E Lamers, and Keith M. Kerr

Subjects
Cancer Research, Poly ADP ribose polymerase, Drug resistance, Synthetic lethality, Biology, medicine.disease_cause, Evasion (ethics), medicine.disease, Cell biology, Oncology, Apoptosis, Cancer research, medicine, Non small cell, biological phenomena, cell phenomena, and immunity, Carcinogenesis, Lung cancer
Abstract

e13519 Background: Evasion of apoptosis contributes to both tumorigenesis and drug resistance. The proapoptotic BCL-2 family proteins BAX and BAK are critical regulators of mitochondrial apoptosis....

Published
2011
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