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Your search keyword '"de Gruijl, Tanja D."' showing total 21 results
Start Over Author "de Gruijl, Tanja D." Search Limiters Peer Reviewed Publisher american society of hematology
21 results on '"de Gruijl, Tanja D."'

1. Bispecific Vγ9Vδ2-T and Type 1 NKT Cell Engager Lava-051 As First-in-Class Clinical Candidate to Target CD1d Expressing CLL, MM and AML

Author

Lameris, Roeland, primary, Ruben, Jurjen M, additional, Weerdt, Iris de, additional, Roovers, Rob, additional, van de Donk, Niels W.C.J., additional, Broyl, Annemiek, additional, Kater, Arnon P., additional, Riedl, Thilo, additional, Iglesias, Victoria, additional, Winograd, Benjamin, additional, Adang, Anton EP, additional, de Gruijl, Tanja D., additional, Parren, Paul W. H. I., additional, and Vliet, Hans J. van der, additional

Published
2021
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3. Improving CLL Vγ9Vδ2-T–cell fitness for cellular therapy by ex vivo activation and ibrutinib

Author

de Weerdt, Iris, primary, Hofland, Tom, primary, Lameris, Roeland, primary, Endstra, Sanne, primary, Jongejan, Aldo, primary, Moerland, Perry D., primary, de Bruin, Renee C. G., primary, Remmerswaal, Ester B. M., primary, ten Berge, Ineke J. M., primary, Liu, Nora, primary, van der Stelt, Mario, primary, Faber, Laura M., primary, Levin, Mark-David, primary, Eldering, Eric, primary, Tonino, Sanne H., primary, de Gruijl, Tanja D., primary, van der Vliet, Hans J., primary, and Kater, Arnon P., primary

Published
2018
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6. Chronic Lymphocytic Leukemia (CLL) Cells Are Susceptible to γδ-T Cell Mediated Killing, Provided CLL-Derived γδ-T Cell Dysfunction Can be Reversed

Author

de Weerdt, Iris, primary, Terpstra, Sanne, additional, Hofland, Tom, additional, Lameris, Roeland, additional, de Bruin, Renee C.G., additional, Levin, Mark-David, additional, Remmerswaal, Ester B.M., additional, ten Berge, Ineke J.M., additional, Tonino, Sanne H., additional, de Gruijl, Tanja D, additional, van der Vliet, Hans, additional, and Kater, Arnon P., additional

Published
2015
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7. Clinical and Immunological Results Of a Phase I/IIa Study Of Allogeneic Dendritic Cell (DC) Vaccination, An “off The shelf” Treatment To Prevent Or Delay Relapse In Elderly Patients With Acute Myeloid Leukemia

Author

van de Loosdrecht, Arjan A, primary, van Wetering, Sandra, additional, Santegoeds, Saskia, additional, Singh, Satwinder Kaur, additional, Koppes, Malika, additional, Hall, Anthony, additional, Kruisbeek, Ada M., additional, de Gruijl, Tanja D., additional, and Ossenkoppele, Gert J., additional

Published
2013
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9. Response: Breslow thickness and excision interval affect the activation state of Langerhans cells in melanoma sentinel lymph nodes

Author

van den Hout, Mari F. C. M., primary, Koster, Bas D., additional, Sluijter, Berbel J. R., additional, van Leeuwen, Paul A. M., additional, Meijer, Sybren, additional, van den Tol, Monique Petrousjka, additional, van den Eertwegh, Alfons J. M., additional, Scheper, Rik J., additional, van de Ven, Rieneke, additional, and de Gruijl, Tanja D., additional

Published
2012
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10. Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation

Author

van de Ven, Rieneke, primary, van den Hout, Mari F. C. M., additional, Lindenberg, Jelle J., additional, Sluijter, Berbel J. R., additional, van Leeuwen, Paul A. M., additional, Lougheed, Sinéad M., additional, Meijer, Sybren, additional, van den Tol, M. Petrousjka, additional, Scheper, Rik J., additional, and de Gruijl, Tanja D., additional

Published
2011
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14. Functional PRAME Specific T Cells Can Be Cultured From CD8+ Cells From Healthy Donors but Not From Patients at First CR: Implications for Immunotherapeutic Strategies in AML.

Author

van den Ancker, Willemijn, primary, Westers, Theresia M, additional, Bontkes, Hetty J, additional, Wulandari, Dewi, additional, Hooijberg, Erik, additional, Stam, Anita GM, additional, Santegoets, Saskia JAM, additional, Ossenkoppele, Gert J, additional, de Gruijl, Tanja D, additional, and van de Loosdrecht, Arjan A, additional

Published
2009
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15. Comparative Analysis of CD8+ t Cell Priming Efficiencies against a Panel of Leukemia-Associated HLA-A2 Restricted Epitopes Identifies PRAME as a Possible Vaccination Target in AML

Author

van den Ancker, Willemijn, primary, Westers, Theresia M, primary, Bontkes, Hetty J, primary, Hooijberg, Erik, primary, Stam, Anita GM, primary, Santegoets, Saskia JAM, primary, Ossenkoppele, Gert J, primary, de Gruijl, Tanja D, primary, and van de Loosdrecht, Arjan A, primary

Published
2008
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16. A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration

Author

van de Ven, Rieneke, primary, Scheffer, George L., additional, Reurs, Anneke W., additional, Lindenberg, Jelle J., additional, Oerlemans, Ruud, additional, Jansen, Gerrit, additional, Gillet, Jean-Pierre, additional, Glasgow, Joel N., additional, Pereboev, Alexander, additional, Curiel, David T., additional, Scheper, Rik J., additional, and de Gruijl, Tanja D., additional

Published
2008
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20. Notch controls generation and function of human effector CD8+ T cells.

Author

Kuijk, Loes M., Verstege, Marleen I., Rekers, Niels V., Bruijns, Sven C., Hooijberg, Erik, Roep, Bart O., de Gruijl, Tanja D., van Kooyk, Yvette, and Unger, Wendy W. J.

Subjects
*NOTCH genes, *T cell receptors, *DENDRITIC cells, *ANTIGEN presenting cells, *CELL physiology, *IMMUNOTHERAPY
Abstract

The generation of effector CD8+ T cells with lytic capacity is crucial for tumor control. Dendritic cells (DCs) provide important signals to promote naive CD8+ T cell priming and activation of effector T cells. Here, we report that the Notch pathway has an important role in both these processes in human CD8+ T cells. Activated monocyte-derived DCs express Notch ligands Jaggedi and Delta-like4, whereas naive CD8+ T cells express Notch2. The role for Notch signaling in CD8+ T cell priming was determined using an ex-vivo model system in which tumor antigen-specific primary CD8+ T cell responses were measured. Inhibition of Notch using γ-secretase inhibitors or soluble Delta-like4-Fc during activation reduced expansion of antigen-specific CD8+ T cells, which was mirrored by decreased frequencies of interferon (IFN)-γ-, tumor necrosis factor-α-, and granzymeB-producing CD8+ T cells. Moreover, T cells primed when Notch signaling was prevented are functionally low-avidity T cells. In addition, Notch partially regulates established effector T cell function. Activation-induced Notch signaling is needed for IFN-γ release but not for cytolytic activity. These data indicate that Notch signaling controls human CD8+ T cell priming and also influences effector T cell functions. This may provide important information for designing new immunotherapies for treatment of cancer. [ABSTRACT FROM AUTHOR]

Published
2013
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21. Breslow thickness and excision interval affect the activation state of Langerhans cells in melanoma sentinel lymph nodes.

Author

van den Hout, Mari F. C. M., Koste, Bas D., Sluijter, Berbel J. R., van Leeuwen, Paul A. M., Meijer, Sybren, van den Toi, Monique Petrousjka, van den Eertwegh, Alfons J. M., Scheper, Rik J., van de Ven, Rieneke, and de Gruijl, Tanja D.

Subjects
*LETTERS to the editor, *LYMPH nodes, *T cells
Abstract

A response by Mari F.C.M. van den Hout and colleagues to a letter to the editor about their article "Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation," in a 2011 issue of the jurnal is presented.

Published
2012
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