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Your search keyword '"Marcogliese, Andrea N"' showing total 6 results
Start Over Author "Marcogliese, Andrea N" Publisher american society of hematology
6 results on '"Marcogliese, Andrea N"'

1. Ex Vivo Drug Sensitivity Assay Correlates with Clinical Response and Identifies Panobinostat and Bortezomib As a Potential Novel Drug Combination for Pediatric AML

Author

Strachan, Debbie C, primary, Gu, Christine, additional, Kita, Ryosuke, additional, Richardson, Michelle A, additional, Anderson, Erica K, additional, Gonzalez, Alan K, additional, Keogh, Noah J, additional, Oviedo, Hailey H, additional, Alozie, Michelle C, additional, Rashid, Raushan, additional, Terrell, Maci, additional, Marcogliese, Andrea N, additional, Santaguida, Marianne T, additional, and Stevens, Alexandra McLean, additional

Published
2021
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2. Venetoclax for Acute Myeloid Leukemia in Pediatric Patients: A Texas Medical Center Collaboration

Author

Trabal, Adriana, primary, Gibson, Amber, additional, McCall, David, additional, Mahadeo, Kris M, additional, Toepfer, Laurie, additional, Roth, Michael E., additional, Buzbee, Meridith, additional, Kadia, Tapan M., additional, Garces, Sofia, additional, Konopleva, Marina, additional, DiNardo, Courtney D., additional, Daver, Naval, additional, Short, Nicholas J., additional, Issa, Ghayas C., additional, Ravandi, Farhad, additional, Nunez, Cesar, additional, Khazal, Sajad J, additional, Paek, Hana, additional, Brackett, Julienne, additional, Garcia-Manero, Guillermo, additional, Kantarjian, Hagop, additional, Marcogliese, Andrea N, additional, Dreyer, ZoAnn, additional, Redell, Michele S., additional, Yi, Joanna S., additional, McLean Stevens, Alexandra, additional, and Cuglievan, Branko, additional

Published
2021
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3. Syndromic congenital myelofibrosis associated with a loss-of-function variant in RBSN

Author

Magoulas, Pilar L., primary, Shchelochkov, Oleg A., additional, Bainbridge, Matthew N., additional, Ben-Shachar, Shay, additional, Yatsenko, Svetlana, additional, Potocki, Lorraine, additional, Lewis, Richard A., additional, Searby, Charles, additional, Marcogliese, Andrea N., additional, Elghetany, M. Tarek, additional, Zapata, Gladys, additional, Hernández, Paula P., additional, Gadkari, Manasi, additional, Einhaus, Derek, additional, Muzny, Donna M., additional, Gibbs, Richard A., additional, Bertuch, Alison A., additional, Scott, Daryl A., additional, Corvera, Silvia, additional, and Franco, Luis M., additional

Published
2018
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6. Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice.

Author

Qing-Shuo Zhang, Weiliang Tang, Deater, Matthew, Ngoc Phan, Marcogliese, Andrea N., Hui Li, Al-Dhalimy, Muhsen, Major, Angela, Olson, Susan, Monnat, Raymond J., and Grompe, Markus

Subjects
*METFORMIN, *FANCONI'S anemia, *HEMATOPOIESIS, *AMINOGUANIDINE, *DNA damage, *LABORATORY mice
Abstract

Fanconi anemia (FA) is an inherited bone marrow failure disorder associated with a high incidence of leukemia and solid tumors. Bone marrow transplantation is currently the only curative therapy for the hematopoietic complications of this disorder. However, long-term morbidity and mortality remain very high, and new therapeutics are badly needed. Here we show that the widely used diabetes drug metformin improves hematopoiesis and delays tumor formation in Fancd2-/- mice. Metformin is the first compound reported to improve both of these FA phenotypes. Importantly, the beneficial effects are specific toFA mice and are not seen in the wild-type controls. In this preclinical model of FA, metformin outperformed the current standard of care, oxymetholone, by improving peripheral blood counts in Fancd2-/- mice significantly faster. Metformin increased the size of the hematopoietic stem cell compartment and enhanced quiescence in hematopoietic stem and progenitor cells. In tumor-prone Fancd2-/-Trp53+/- mice, metformin delayed the onset of tumors and significantly extended the tumor-free survival time. In addition, we found that metformin and the structurally related compound aminoguanidine reduced DNA damage and ameliorated spontaneous chromosome breakage and radials in human FA patient-derived cells. Our results also indicate that aldehyde detoxificationmight be one of the mechanisms by whichmetformin reducesDNAdamage in FA cells. [ABSTRACT FROM AUTHOR]

Published
2016
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