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1. Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells.

Author

Witt RG, Kreger EM, Buckman LB, Moradi PW, Ho PT, Derderian SC, Tsai P, Baker C, Schramm N, Cleary R, Garcia JV, and MacKenzie TC

Subjects
Animals, Antibodies administration & dosage, Antibodies pharmacology, Cell Differentiation, Chimerism, Fetal Blood transplantation, Humans, Mice, Mice, SCID, Models, Animal, Proto-Oncogene Proteins c-kit immunology, Cell Lineage, Fetal Diseases therapy, Graft Survival drug effects, Hematopoietic Stem Cell Transplantation methods, Transplantation, Heterologous methods
Abstract

IUHCT of human cord blood-derived CD34 + cells into fetal NSG mice results in systemic multilineage engraftment with human cells.Preconditioning with in utero injection of an anti-c-Kit receptor antibody (ACK2) results in an improved rate of engraftment., Competing Interests: Conflict-of-interest disclosure: The authors declare no competing financial interests.

Published
2018
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