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Your search keyword '"Przepiorka, D."' showing total 14 results
Start Over Author "Przepiorka, D." Publisher american society of hematology
14 results on '"Przepiorka, D."'

1. Daclizumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for treatment of acute graft-versus-host disease

Author

Przepiorka, D., primary, Kernan, N. A., additional, Ippoliti, C., additional, Papadopoulos, E. B., additional, Giralt, S., additional, Khouri, I., additional, Lu, J.-G., additional, Gajewski, J., additional, Durett, A., additional, Cleary, K., additional, Champlin, R., additional, Andersson, B. S., additional, and Light, S., additional

Published
2000
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2. Tacrolimus and minidose methotrexate for prevention of acute graft- versus-host disease after matched unrelated donor marrow transplantation

Author

Przepiorka, D, primary, Ippoliti, C, additional, Khouri, I, additional, Woo, M, additional, Mehra, R, additional, Le Bherz, D, additional, Giralt, S, additional, Gajewski, J, additional, Fischer, H, additional, Fritsche, H, additional, Deisseroth, AB, additional, Cleary, K, additional, Champlin, R, additional, Besien, K, additional, Andersson, B, additional, Maher, R, additional, and Fitzsimmons, W, additional

Published
1996
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6. Allogeneic blood stem cell transplantation: peripheralization and yield of donor-derived primitive hematopoietic progenitor cells (CD34+ Thy- 1dim) and lymphoid subsets, and possible predictors of engraftment and graft-versus-host disease

Author

Korbling, M, primary, Huh, YO, additional, Durett, A, additional, Mirza, N, additional, Miller, P, additional, Engel, H, additional, Anderlini, P, additional, van Besien, K, additional, Andreeff, M, additional, and Przepiorka, D, additional

Published
1995
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14. Weighty choices: selecting optimal G-CSF doses for stem cell mobilization to optimize yield.

Author

Farhadfar N, Hsu JW, Logan BR, Sees JA, Chitphakdithai P, Sugrue MW, Abdel-Azim H, Anderlini PN, Bredeson C, Chhabra S, Diaz MA, Ganguly S, Hematti P, Kamble RT, Kasow KA, Lazarus HM, Lynch DK, Murthy HS, Olsson RF, Papari M, Przepiorka D, Savani BN, Schears R, Seo S, Solh MM, Spitzer T, Yared JA, Pulsipher MA, Shah NN, Switzer GE, Confer DL, Shaw BE, and Wingard JR

Subjects
Body Mass Index, Body Weight, Humans, Unrelated Donors, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Mobilization
Abstract

There are limited data on the effect of donor body mass index (BMI) on peripheral blood stem cell (PBSC) mobilization response to granulocyte colony-stimulating factor (G-CSF), especially in unrelated donors. Obesity has been associated with persistent leukocytosis, elevated circulating progenitor cells, and enhanced stem cell mobilization. Therefore, we hypothesized that adequate collection of CD34+ cells may be achieved with lower doses (per kilogram of body weight) of G-CSF in donors with higher BMI compared with donors with lower BMI. Using the Center for International Blood and Marrow Transplant Research database, we evaluated the impact of donor BMI on G-CSF-mobilized PBSC yield in healthy unrelated donors. We examined 20 884 PBSC donations collected at National Marrow Donor Program centers between 2006 and 2016. We found significantly higher collection yields in obese and severely obese donors compared with normal and overweight donors. An increase in average daily G-CSF dose was associated with an increase in stem cell yield in donors with normal or overweight BMI. In contrast, an increase in average daily G-CSF dose beyond 780 μg per day in obese and 900 μg per day in severely obese donors did not increase cell yield. Pain and toxicities were assessed at baseline, during G-CSF administration, and postcollection. Obesity was associated with higher levels of self-reported donation-related pain and toxicities in the pericollection and early postdonation recovery periods. This study suggests a maximum effective G-CSF dose for PBSC mobilization in obese and severely obese donors, beyond which higher doses of G-CSF add no increased yield.

Published
2020
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