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3. JAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality

4. MPN patients with low mutant JAK2 allele burden show late expansion restricted to erythroid and megakaryocytic lineages

5. JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms

6. JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis

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