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Your search keyword '"Wielockx, Ben"' showing total 10 results
Start Over Author "Wielockx, Ben" Publisher american society of hematology
10 results on '"Wielockx, Ben"'

2. HIF2α is a direct regulator of neutrophil motility

Author

Sormendi, Sundary, primary, Deygas, Mathieu, additional, Sinha, Anupam, additional, Bernard, Mathilde, additional, Krüger, Anja, additional, Kourtzelis, Ioannis, additional, Le Lay, Gregoire, additional, Sáez, Pablo J., additional, Gerlach, Michael, additional, Franke, Kristin, additional, Meneses, Ana, additional, Kräter, Martin, additional, Palladini, Alessandra, additional, Guck, Jochen, additional, Coskun, Ünal, additional, Chavakis, Triantafyllos, additional, Vargas, Pablo, additional, and Wielockx, Ben, additional

Published
2021
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3. B Cell Specific Knockdown of the Erythropoietin (EPO) Receptor Attenuates EPO-Induced Bone Loss in Mice

Author

Kolomansky, Albert, primary, Deshet-Unger, Naamit, primary, Ben-Califa, Nathalie, primary, Awida, Zamzam, primary, Ibrahim, Maria, primary, Liron, Tamar, primary, Hiram-Bab, Sahar, primary, Oster, Howard S., primary, Mittelman, Moshe, primary, Rauner, Martina, primary, Wielockx, Ben, primary, Gabet, Yankel, primary, and Neumann, Drorit, primary

Published
2019
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4. Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases

Author

Ramasz, Beáta, primary, Krüger, Anja, additional, Reinhardt, Julia, additional, Sinha, Anupam, additional, Gerlach, Michael, additional, Gerbaulet, Alexander, additional, Reinhardt, Susanne, additional, Dahl, Andreas, additional, Chavakis, Triantafyllos, additional, Wielockx, Ben, additional, and Grinenko, Tatyana, additional

Published
2019
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8. HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress

Author

Singh, Rashim Pal, primary, Franke, Kristin, additional, Kalucka, Joanna, additional, Mamlouk, Soulafa, additional, Muschter, Antje, additional, Gembarska, Agnieszka, additional, Grinenko, Tatyana, additional, Willam, Carsten, additional, Naumann, Ronald, additional, Anastassiadis, Konstantinos, additional, Stewart, A. Francis, additional, Bornstein, Stefan, additional, Chavakis, Triantafyllos, additional, Breier, Georg, additional, Waskow, Claudia, additional, and Wielockx, Ben, additional

Published
2013
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9. HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α–induced excessive erythropoiesis

Author

Franke, Kristin, primary, Kalucka, Joanna, additional, Mamlouk, Soulafa, additional, Singh, Rashim Pal, additional, Muschter, Antje, additional, Weidemann, Alexander, additional, Iyengar, Vasuprada, additional, Jahn, Steffen, additional, Wieczorek, Kathrin, additional, Geiger, Kathrin, additional, Muders, Michael, additional, Sykes, Alex M., additional, Poitz, David M., additional, Ripich, Tatsiana, additional, Otto, Teresa, additional, Bergmann, Sybille, additional, Breier, Georg, additional, Baretton, Gustavo, additional, Fong, Guo-Hua, additional, Greaves, David R., additional, Bornstein, Stefan, additional, Chavakis, Triantafyllos, additional, Fandrey, Joachim, additional, Gassmann, Max, additional, and Wielockx, Ben, additional

Published
2013
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10. HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.

Author

Pal Singh, Rashim, Franke, Kristin, Kalucka, Joanna, Mamlouk, Soulafa, Muschter, Antje, Gembarska, Agnieszka, Grinenko, Tatyana, Willam, Carsten, Naumann, Ronald, Anastassiadis, Konstantinos, Stewart, A. Francis, Bornstein, Stefan, Chavakis, Triantafyllos, Breier, Georg, Waskow, Claudia, and Wielockx, Ben

Subjects
*HYPOXEMIA, *HEMATOPOIETIC stem cells, *HYPOXIA-inducible factors, *OXYGEN detectors, *BONE marrow transplantation, *CHIMERISM
Abstract

Hypoxia is a prominent feature in the maintenance of hematopoietic stem cell (HSC) quiescence and multipotency. Hypoxia-inducible factor (HIF) prolyl hydroxylase domain proteins (PHDs) serve as oxygen sensors and may therefore regulate this system. Here, we describe a mouse line with conditional loss of HIF prolyl hydroxylase 2 (PHD2) in very early hematopoietic precursors that results in self-renewal of multipotent progenitors under steady-state conditions in a HlFlα- and SMAD7-dependent manner. Competitive bone marrow (BM) transplantations show decreased peripheral and central chimerism of PHD2-deficient cells but not of the most primitive progenitors. Conversely, in whole BM transfer, PHD2-deficient HSCs replenish the entire hematopoietic system and display an enhanced self-renewal capacity reliant on HIF1α. Taken together, our results demonstrate that loss of PHD2 controls the maintenance of the HSC compartment under physiological conditions and causes the outcompetition of PHD2-deficient hematopoietic cells by their wild-type counterparts during stress while promoting the self-renewal of very early hematopoletic progenitors. [ABSTRACT FROM AUTHOR]

Published
2013
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