1. Renal Function Profile in White Kidney Donors: The First 4 Decades
- Author
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Arthur J. Matas, Aleksandra Kukla, Scott Reule, Richard Spong, Hassan N. Ibrahim, Danielle Berglund, Robert N. Foley, Naim Issa, and Gretchen Sieger
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Time Factors ,030232 urology & nephrology ,Urology ,Renal function ,030230 surgery ,urologic and male genital diseases ,Kidney ,Nephrectomy ,Risk Assessment ,White People ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Clinical Research ,Diabetes mellitus ,medicine ,Living Donors ,Humans ,Proteinuria ,urogenital system ,business.industry ,Hazard ratio ,Kidney donation ,General Medicine ,medicine.disease ,Confidence interval ,female genital diseases and pregnancy complications ,medicine.anatomical_structure ,Nephrology ,Donation ,Hypertension ,Kidney Failure, Chronic ,Female ,medicine.symptom ,business ,Glomerular Filtration Rate - Abstract
Previous studies reported the risk of ESRD after kidney donation, but not the renal outcomes that precede ESRD. Here, we estimated the risk of proteinuria, reduced GFR, and ESRD in 3956 white kidney donors, assessed the contribution of postdonation hypertension and diabetes to these outcomes, and developed a risk calculator. After a mean±SD follow-up of 16.6±11.9 years, 215 (6.1%) donors developed proteinuria. Men had a higher risk of proteinuria (hazard ratio [HR], 1.56; 95% confidence interval [95% CI], 1.18 to 2.05; P2-fold higher risk of ESRD. Models predicting proteinuria and reduced eGFR performed well (C-index 0.77–1.00). In conclusion, severe reduction in GFR and ESRD after kidney donation were uncommon and were highly associated with postdonation diabetes and hypertension. Furthermore, information available before donation may predict long-term renal outcomes in white living kidney donors.
- Published
- 2016