Search

Your search keyword '"Nanayakkara, CM"' showing total 1 results
Start Over Author "Nanayakkara, CM" Publisher american society of pharmacognosy

Refine your results

1 results on '"Nanayakkara, CM"'

1. Serpulanines A to C, N-Oxidized Tyrosine Derivatives Isolated from the Sri Lankan Fungus Serpula sp.: Structure Elucidation, Synthesis, and Histone Deacetylase Inhibition.

Author

Williams DE, Gunasekara NW, Ratnaweera PB, Zheng Z, Ellis S, Dada S, Patrick BO, Wijesundera RLC, Nanayakkara CM, Jefferies WA, de Silva ED, and Andersen RJ

Subjects
Animals, Cell Line, Tumor, Crystallography, X-Ray methods, HeLa Cells, Histone Deacetylase Inhibitors isolation & purification, Humans, Hydroxamic Acids chemistry, Hydroxamic Acids pharmacology, Lung Neoplasms drug therapy, Mice, Oxidation-Reduction, Tyrosine chemistry, Tyrosine isolation & purification, Basidiomycota chemistry, Histone Deacetylase Inhibitors chemistry, Histone Deacetylase Inhibitors pharmacology, Tyrosine analogs & derivatives, Tyrosine pharmacology
Abstract

Serpulanines A (1), B (2), and C (3) have been isolated from extracts of the rare Sri Lankan macrofungus Serpula sp. The structures of 1, 2, and 3 were elucidated by a combination of spectroscopic and single-crystal X-ray diffraction analyses. Serpulanines A (1) and B (2) both contain the rare (E)-2-hydroxyimino hydroxamic acid functional group array. A proposed biogenesis for serpulanine B (2) suggests that its (E)-2-hydroxyimino hydroxamic acid moiety arises from a diketopiperazine precursor. Synthetic serpulanine A (1) inhibited class I/II histone deacetylases in murine metastatic lung carcinoma cells with an IC 50 of 7 μM.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results