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Three previously undescribed indole alkaloids, named latifolianine A ( 1 ) and latifoliaindoles A and B ( 2 and 3 ), along with 10 known compounds ( 4 - 13 ), were isolated from the heartwood of Nauclea latifolia . Their structures were elucidated based on the analysis of their NMR and MS data. Latifolianine A ( 1 ) represents an unusual and unprecedented monoterpene indole alkaloid unit condensed with an ursane-type pentacyclic triterpenoid moiety. Plausible biogenetic routes toward latifolianine A ( 1 ) and latifoliaindoles A and B ( 2 and 3 ) were proposed. All the isolates were assessed in vitro for their inhibitory effects on Haemophilus influenzae . Naucleidinal ( 7 ) exhibited potent antibacterial activity (MIC value of 3.1 μg/mL) as compared to a reference drug, ciprofloxacin (MIC value of 1.6 μg/mL).

Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A-C (1-3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC₅₀) 0.68 μM) showed inhibitory activity on β-glucuronidase enzyme, while 3 (IC₅₀) 7.69 μM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).