1. Pursaethosides A-E, triterpene saponins from Entada pursaetha.
- Author
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Tapondjou AL, Miyamoto T, Mirjolet JF, Guilbaud N, and Lacaille-Dubois MA
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Cameroon, Drug Screening Assays, Antitumor, Humans, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Saponins chemistry, Saponins pharmacology, Triterpenes chemistry, Triterpenes pharmacology, Tumor Cells, Cultured, Antineoplastic Agents, Phytogenic isolation & purification, Mimosa chemistry, Plants, Medicinal chemistry, Saponins isolation & purification, Triterpenes isolation & purification
- Abstract
Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the n-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.
- Published
- 2005
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