1. The alkaloids of Artabotrys uncinatus.
- Author
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Hsieh TJ, Chang FR, Chia YC, Chen CY, Lin HC, Chiu HF, and Wu YC
- Subjects
- Alkaloids chemistry, Alkaloids pharmacology, Antithrombins metabolism, Aporphines pharmacology, Carcinoma, Hepatocellular, Chromatography, Thin Layer, Drug Screening Assays, Antitumor, Fibrinogen pharmacology, Gas Chromatography-Mass Spectrometry, Heparin pharmacology, Humans, Isoquinolines pharmacology, Magnetic Resonance Spectroscopy, Medicine, Chinese Traditional, Molecular Conformation, Molecular Structure, Plant Leaves chemistry, Plant Roots chemistry, Plant Stems chemistry, Plants, Medicinal chemistry, Platelet Aggregation Inhibitors chemistry, Platelet Aggregation Inhibitors isolation & purification, Platelet Aggregation Inhibitors pharmacology, Porphyrins chemistry, Porphyrins pharmacology, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Taiwan, Thrombin metabolism, Tumor Cells, Cultured drug effects, Alkaloids isolation & purification, Annonaceae chemistry, Porphyrins isolation & purification
- Abstract
A novel type of alpha,beta-butenolide alkaloid, uncinine (1), two novel oxoaporphines, artabonatine C (2) and artabonatine D (3), a new oxazoloaporphine, artabonatine E (4), and a new 7,7'-bisdehydroaporphine, artabonatine F (5), along with 25 known alkaloids, were isolated from Artabotrys uncinatus. The structures of 1-5 were determined using NMR and mass spectral data. Atherospermidine and squamolone exhibited cytotoxicity against hepatocarcinoma cancer cell lines (Hep G(2) and 2,2,15), and the activity of some of the alkaloids in an antithrombin assay is also discussed.
- Published
- 2001
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