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Your search keyword '"King, Christopher L."' showing total 16 results
Start Over Author "King, Christopher L." Publisher american society of tropical medicine and hygiene
16 results on '"King, Christopher L."'

1. Enhancing Malaria Research, Surveillance, and Control in Endemic Areas of Kenya and Ethiopia

Author

Githure, John I., primary, Yewhalaw, Delenasaw, additional, Atieli, Harrysone, additional, Hemming-Schroeder, Elizabeth, additional, Lee, Ming-Chieh, additional, Wang, Xiaoming, additional, Zhou, Guofa, additional, Zhong, Daibin, additional, King, Christopher L., additional, Dent, Arlene, additional, Mukabana, Wolfgang Richard, additional, Degefa, Teshome, additional, Hsu, Kuolin, additional, Githeko, Andrew K., additional, Okomo, Gordon, additional, Dayo, Lilyana, additional, Tushune, Kora, additional, Omondi, Charles O., additional, Taffese, Hiwot S., additional, Kazura, James W., additional, and Yan, Guiyun, additional

Published
2022
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2. Impact of Environmental Modifications on the Ecology, Epidemiology, and Pathogenesis of Plasmodium falciparum and Plasmodium vivax Malaria in East Africa

Author

Yan, Guiyun, primary, Lee, Ming-Chieh, additional, Zhou, Guofa, additional, Jiang, Ai-Ling, additional, Degefa, Teshome, additional, Zhong, Daibin, additional, Wang, Xiaoming, additional, Hemming-Schroeder, Elizabeth, additional, Mukabana, Wolfgang R., additional, Dent, Arlene E., additional, King, Christopher L., additional, Hsu, Kuolin, additional, Beeson, James, additional, Githure, John I., additional, Atieli, Harrysone, additional, Githeko, Andrew K., additional, Yewhalaw, Delenasaw, additional, and Kazura, James W., additional

Published
2022
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4. Biosignatures of Exposure/Transmission and Immunity

Author

King, Christopher L., primary, Davies, D. Huw, additional, Felgner, Phil, additional, Baum, Elizabeth, additional, Jain, Aarti, additional, Randall, Arlo, additional, Tetteh, Kevin, additional, Drakeley, Christopher J., additional, and Greenhouse, Bryan, additional

Published
2015
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7. Serologic Evidence of Arboviral Infections among Humans in Kenya

Author

Sutherland, Laura J., primary, Sang, Rosemary C., additional, King, Charles H., additional, LaBeaud, A. Desiree, additional, Cash, Ayla A., additional, King, Christopher L., additional, Weaver, Scott C., additional, Malhotra, Indu, additional, Huang, Yan-Jang Scott, additional, and Moormann, Ann M., additional

Published
2011
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11. THE RISK OF MALARIAL INFECTIONS AND DISEASE IN PAPUA NEW GUINEAN CHILDREN

Author

MICHON, PASCAL, primary, SCHOFIELD, LOUIS, additional, REEDER, JOHN C., additional, BEESON, JAMES G., additional, SCHOEPFLIN, SONJA, additional, COLE-TOBIAN, JENNIFER L., additional, DABOD, ELIJAH, additional, ZIMMERMAN, PETER A., additional, TARONGKA, NANDAO, additional, MUELLER, IVO, additional, SUSAPU, MELINDA, additional, KING, CHRISTOPHER L., additional, and IGU, JENNIFER, additional

Published
2007
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16. A Reevaluation of the Tolerability and Effects of Single-Dose Ivermectin Treatment on Onchocerca volvulus Microfilariae in the Skin and Eyes in Eastern Ghana.

Author

Opoku NO, Gyasi ME, Doe F, Lew D, Hong AR, Chithenga S, Fischer PU, King CL, and Weil GJ

Subjects
Adult, Animals, Cohort Studies, Eye drug effects, Eye parasitology, Female, Ghana epidemiology, Humans, Male, Mass Drug Administration, Middle Aged, Onchocerca volvulus growth & development, Onchocerca volvulus parasitology, Onchocerciasis epidemiology, Onchocerciasis parasitology, Onchocerciasis pathology, Skin drug effects, Skin parasitology, Anthelmintics therapeutic use, Ivermectin therapeutic use, Microfilariae drug effects, Onchocerca volvulus drug effects, Onchocerciasis drug therapy
Abstract

Mass administration of ivermectin (IVM) has significantly reduced onchocerciasis prevalence, intensity, and morbidity in most endemic areas. Most IVM clinical trials were performed long ago in persons with high-intensity infections that are uncommon in West Africa today. This cohort treatment study recruited participants from a hypoendemic area in eastern Ghana to reevaluate the efficacy and tolerability of IVM with a special focus on the kinetics of microfilaria (Mf) clearance. Mf in the skin and anterior chambers (AC) were assessed by skin snip and slit lamp examinations at baseline and at 3 and 6 months after treatment with IVM 150 μg/kg. Most participants (184-231, 79.7%) enrolled were treatment-naïve. The baseline geometric mean skin Mf count was 12.67/mg (range 3-86). Although persons with MfAC at baseline (64/231, 27%) had significantly higher skin Mf counts than people without MfAC, 7 of 39 (15%) of persons with skin Mf counts in the range of 3-5 Mf/mg had MfAC. Skin Mf were detected in 14% (31/218) and 45% (96/216) of participants 3 and 6 months after IVM treatment, respectively. MfAC were detected in 12 of 212 (5.7%) study participants at 6 months. 81% (187 of 231) of participants experienced 439 adverse events within 7 days after treatment; all adverse events were mild (96.1%) or moderate. This study has provided new data on the kinetics of Mf in the skin and eyes after IVM treatment of persons with light to moderate intensity Onchocerca volvulus infections that are common in Africa at this time.

Published
2021
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