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Your search keyword '"Antic, Nick A."' showing total 11 results
Start Over Author "Antic, Nick A." Publisher american thoracic society
11 results on '"Antic, Nick A."'

2. Comparative Effectiveness of Supine Avoidance versus Continuous Positive Airway Pressure for Treating Supine-isolated Sleep Apnea: A Clinical Trial.

Author

Rahimi, Matthew M., Vakulin, Andrew, McEvoy, R. Douglas, Barnes, Maree, Quinn, Stephen J., Mercer, Jeremy D., O'Grady, Amanda, Antic, Nick A., and Catcheside, Peter G.

Subjects
CONTINUOUS positive airway pressure, DROWSINESS, SLEEP apnea syndromes, PATIENT compliance, CLINICAL trials, EPWORTH Sleepiness Scale
Abstract

Rationale: About 20--35% of patients with obstructive sleep apnea (OSA) have supine-isolated OSA, for which supine sleep avoidance could be an effective therapy. However, traditional supine discomfort--based methods show poor tolerance and compliance to treatment and so cannot be recommended. Supine alarm devices show promise, but evidence to support favorable adherence to treatment and effectiveness at reducing excessive daytime sleepiness compared with continuous positive airway pressure (CPAP) remains limited. Objectives: To establish if alarm-based supine-avoidance treatment in patients with supine-isolated OSA is noninferior to CPAP in reducing daytime sleepiness. Methods: After baseline questionnaire administration and in-home supine-time and polysomnography assessments, patients with supine-isolated OSA and Epworth Sleepiness Scale scores >8 were randomized to >6weeks of supine-avoidance or CPAP treatment, followed by crossover to the remaining treatment with repeat assessments. Noninferiority was assessed from change in Epworth Sleepiness Scale with supine avoidance compared with CPAP using a prespecified noninferiority margin of 1.5. Average nightly treatment use over all nights and treatment efficacy and effectiveness at reducing respiratory disturbances were also compared between treatments. Results: The reduction in sleepiness score with supine avoidance (mean [95% confidence interval], 21.9 [22.8 to 21.0]) was noninferior to that with CPAP (22.4 [23.3 to 21.4]) (supine avoidance--CPAP difference, 20.4 [21.3 to 0.6]), and the lower confidence limit did not cross the noninferiority margin of 1.5 (P = 0.021). Average treatment use was higher with supine avoidance compared with CPAP (mean6standard deviation, 5.762.4 vs. 3.962.7 h/night; P<0.001). Conclusions: In patients with supine-isolated OSA, vibrotactile supine alarm device therapy is noninferior to CPAP for reducing sleepiness and shows superior treatment adherence. Clinical trial registered with www.anzctr.org.au (ACTRN 12613001242718). [ABSTRACT FROM AUTHOR]

Published
2024
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3. Sleep Rhythms

Author

Aiyappan, Vinod, primary, Sanders, Prashanthan, additional, McEvoy, Doug, additional, and Antic, Nick A., additional

Published
2013
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5. Predictors Of Long Term Adherence To Continuous Positive Airway Pressure Therapy In Patients With Obstructive Sleep Apnea And Cardiovascular Disease In The SAVE Study

Author

Chai-Coetzer, Ching Li, primary, Luo, Yuan-Ming, additional, Antic, Nick A., additional, Chen, Baoyuan, additional, He, Quanying, additional, Heeley, Emma, additional, Huang, Shaoguang, additional, Anderson, Craig, additional, Zhong, Nanshan, additional, and McEvoy, R. D., additional

Published
2012
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6. Hypoglossal Nerve Stimulation Therapy To Treat Obstructive Sleep Apnea: Long-Term Effectiveness Outcomes

Author

Malhotra, Atul, primary, Eastwood, Peter, additional, Hillman, David, additional, Kezirian, Eric J., additional, McEvoy, R. D., additional, Wheatley, John, additional, O'Donoghue, Fergal, additional, Catcheside, Peter, additional, Antic, Nick A., additional, Worsnop, Christopher, additional, Campbell, Matthew, additional, Hee, Geoffrey, additional, Palme, Carsten, additional, Iber, Con, additional, Howell, Michael, additional, Goding, Jr., George, additional, Zammit, Gary, additional, Park, Steven, additional, Claman, David, additional, Huntley, Tod, additional, Smith, Philip L., additional, Schwartz, Alan R., additional, and Barnes, Maree, additional

Published
2012
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7. Hypoglossal Nerve Stimulation Therapy To Treat Obstructive Sleep Apnea: Interim Feasibility Trial Results

Author

Eastwood, Peter R., primary, McEvoy, R D., additional, Wheatley, John, additional, Walsh, Jen, additional, O'Donoghue, Fergal J., additional, Catcheside, Peter G., additional, Tyler, Louise, additional, Maddison, Kath, additional, Rochford, Peter, additional, Antic, Nick, additional, Worsnop, Christopher, additional, churchward, T, additional, Eckert, Danny J., additional, Campbell, Matthew, additional, Hee, Geoffery, additional, Palme, Carsten, additional, Kezerian, Eric, additional, Goding, S, additional, Jordan, Amy S., additional, Smith, Philip L., additional, Schwartz, Alan R., additional, Hillman, David, additional, Malhotra, Atul, additional, and Barnes, Maree, additional

Published
2011
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8. Feasibility Of Hypoglossal Nerve Stimulation Therapy To Treat Obstructive Sleep Apnea

Author

Eastwood, Peter R., primary, Barnes, Maree, additional, McEvoy, R. D., additional, Wheatley, John, additional, Walsh, Jennifer H., additional, O'Donoghue, Fergal J., additional, Catcheside, Peter, additional, Tyler, Louise, additional, Maddison, Kathleen J., additional, Rochford, Peter D., additional, Antic, Nick, additional, Worsnop, Christopher, additional, Churchward, Tom, additional, Eckert, Danny J., additional, Campbell, Matthew C., additional, Hee, Geoff, additional, Palme, Carsten E., additional, Robinson, Samuel H., additional, Kezirian, Eric, additional, Goding, George, additional, Jordan, Amy S., additional, Smith, Philip L., additional, Schwartz, Alan R., additional, Malhotra, Atul, additional, and Hillman, David R., additional

Published
2010
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11. A Randomized Controlled Trial of Nurse-led Care for Symptomatic Moderate–Severe Obstructive Sleep Apnea

Author

Nick A. Antic, Catherine Buchan, R. Doug McEvoy, Simon Eckermann, Samantha Windler, Adrian Esterman, Michael J. Hensley, Matthew T. Naughton, Bernadette Williamson, Sharn Rowland, Antic, Nick A, Buchan, Catherine, Esterman, Adrian, Hensley, Michael, Naughton, Matthew T, Rowland, Sharn, Williamson, Bernadette, Windler, Samantha, Eckermann, Simon, and McEvoy, R Doug

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Polysomnography, medicine.medical_treatment, Critical Care and Intensive Care Medicine, Severity of Illness Index, law.invention, Patient satisfaction, Randomized controlled trial, law, Intensive care, Outcome Assessment, Health Care, Positive airway pressure, Humans, Medicine, Oximetry, Continuous positive airway pressure, Intensive care medicine, obstructive sleep apnea, Sleep Apnea, Obstructive, nurse-led clinics, Continuous Positive Airway Pressure, medicine.diagnostic_test, business.industry, Australia, Sleep apnea, Middle Aged, medicine.disease, respiratory tract diseases, Obstructive sleep apnea, Mental Health, Patient Satisfaction, Quality of Life, Female, business
Abstract

Obstructive sleep apnea (OSA) is a prevalent disease. Often limited clinical resources result in long patient waiting lists. Simpler validated methods of care are needed.To demonstrate that a nurse-led model of care can produce health outcomes in symptomatic moderate-severe OSA not inferior to physician-led care.A randomized controlled multicenter noninferiority clinical trial was performed. Of 1,427 potentially eligible patients at 3 centers, 882 consented to the trial. Of these, 263 were excluded on the basis of clinical criteria. Of the remaining 619, 195 met home oximetry criteria for high-probability moderate-severe OSA and were randomized to 2 models of care: model A, the simplified model, using home autoadjusting positive airway pressure to set therapeutic continuous positive airway pressure (CPAP), with all care supervised by an experienced nurse; and model B, involving two laboratory polysomnograms to diagnose and treat OSA, with clinical care supervised by a sleep physician. The primary end point was change in Epworth Sleepiness Scale (ESS) score after 3 months of CPAP. Other outcome measures were collected.For the primary outcome change in ESS score, nurse-led management was no worse than physician-led management (4.02 vs. 4.15; difference, -0.13; 95% confidence interval: -1.52, 1.25) given a prespecified noninferiority margin of -2 for the lower 95% confidence interval. There were also no differences between both groups in CPAP adherence at 3 months or other outcome measures. Within-trial costs were significantly less in model A.A simplified nurse-led model of care has demonstrated noninferior results to physician-directed care in the management of symptomatic moderate-severe OSA, while being less costly. Clinical trial registered with http://www.anzctr.org.au (ACTRN012605000064606).

Published
2009

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