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Your search keyword '"Bezzerri, Valentino"' showing total 7 results
Start Over Author "Bezzerri, Valentino" Publisher american thoracic society
7 results on '"Bezzerri, Valentino"'

1. PLCB3 Loss of Function Reduces Pseudomonas aeruginosa–Dependent IL-8 Release in Cystic Fibrosis

Author

Rimessi, Alessandro, primary, Bezzerri, Valentino, additional, Salvatori, Francesca, additional, Tamanini, Anna, additional, Nigro, Federica, additional, Dechecchi, Maria Cristina, additional, Santangelo, Alessandra, additional, Prandini, Paola, additional, Munari, Silvia, additional, Provezza, Lisa, additional, Garreau de Loubresse, Nicolas, additional, Muller, Jean, additional, Ribeiro, Carla M. P., additional, Lippi, Giuseppe, additional, Gambari, Roberto, additional, Pinton, Paolo, additional, and Cabrini, Giulio, additional

Published
2018
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2. Transient Receptor Potential Ankyrin 1 Channels Modulate Inflammatory Response in Respiratory Cells from Patients with Cystic Fibrosis

Author

Prandini, Paola, primary, De Logu, Francesco, additional, Fusi, Camilla, additional, Provezza, Lisa, additional, Nassini, Romina, additional, Montagner, Giulia, additional, Materazzi, Serena, additional, Munari, Silvia, additional, Gilioli, Eliana, additional, Bezzerri, Valentino, additional, Finotti, Alessia, additional, Lampronti, Ilaria, additional, Tamanini, Anna, additional, Dechecchi, Maria Cristina, additional, Lippi, Giuseppe, additional, Ribeiro, Carla M., additional, Rimessi, Alessandro, additional, Pinton, Paolo, additional, Gambari, Roberto, additional, Geppetti, Pierangelo, additional, and Cabrini, Giulio, additional

Published
2016
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5. MPB-07 Reduces the Inflammatory Response to Pseudomonas aeruginosa in Cystic Fibrosis Bronchial Cells

Author

Dechecchi, Maria Cristina, primary, Nicolis, Elena, additional, Bezzerri, Valentino, additional, Vella, Antonio, additional, Colombatti, Marco, additional, Assael, Baroukh Maurice, additional, Mettey, Yvette, additional, Borgatti, Monica, additional, Mancini, Irene, additional, Gambari, Roberto, additional, Becq, Frederic, additional, and Cabrini, Giulio, additional

Published
2007
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7. Transcription factor oligodeoxynucleotides to NF-kappaB inhibit transcription of IL-8 in bronchial cells.

Author

Bezzerri V, Borgatti M, Nicolis E, Lampronti I, Dechecchi MC, Mancini I, Rizzotti P, Gambari R, and Cabrini G

Subjects
Bronchi drug effects, Bronchi physiopathology, Cell Nucleus physiology, Cystic Fibrosis genetics, Cystic Fibrosis physiopathology, HIV Long Terminal Repeat, Humans, Pseudomonas aeruginosa physiology, Transcription Factors genetics, Transcription, Genetic drug effects, Interleukin-8 genetics, NF-kappa B genetics, Oligodeoxyribonucleotides pharmacology, Transcription, Genetic genetics
Abstract

Chronic pulmonary inflammation in patients affected by cystic fibrosis (CF) is characterized by massive bronchial infiltrates of neutrophils, which is sustained by the interaction of pathogens (e.g., Pseudomonas aeruginosa) with surface bronchial cells. To explore new treatment options focused on the reduction of neutrophil chemotaxis, we applied the transcription factor (TF) decoy approach, based on the intracellular delivery of double-stranded oligodeoxynucleotides (ODNs) causing inhibition of the binding of TF-related proteins to the different consensus sequences in the promoter of specific genes. In CF bronchial IB3-1 cells, P. aeruginosa induced transcription of the neutrophil chemokines IL-8 and GRO-gamma, of the adhesion molecule intercellular adhesion molecule (ICAM)-1, and of the cytokines IL-1beta and IL-6. Since consensus sequences for the TF, NF-kappaB, are contained in the promoters of all these genes, IB3-1, CuFi-1, Beas-2B, and CaLu-3 cells were transfected with double-stranded TF "decoy" ODNs mimicking different NF-kappaB consensus sequences. IL-8 NF-kappaB decoy ODN partially inhibited the P. aeruginosa-dependent transcription of IL-8, GRO-gamma, and IL-6, whereas decoy ODNs to both HIV-1 long terminal repeat and Igk produced a strong, 80 to 85% inhibition of transcription of IL-8, without reducing that of GRO-gamma, ICAM-1, IL-1beta, and IL-6. In conclusion, intracellular delivery of "decoy" molecules aimed to compete with the TF, NF-kappaB, is a promising strategy to obtain inhibition of IL-8 gene transcription.

Published
2008
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