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Start Over Author "Bourdin, Arnaud" Publisher american thoracic society
29 results on '"Bourdin, Arnaud"'

1. Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma

Author

Wechsler, Michael E, primary, Scelo, Ghislaine, additional, Larenas-Linnemann, Désirée E. S., additional, Torres-Duque, Carlos A., additional, Maspero, Jorge, additional, Tran, Trung N., additional, Murray, Ruth B., additional, Martin, Neil, additional, Menzies-Gow, Andrew N., additional, Hew, Mark, additional, Peters, Matthew J, additional, Gibson, Peter G, additional, Christoff, George C., additional, Popov, Todor A., additional, Côté, Andréanne, additional, Bergeron, Celine, additional, Dorscheid, Delbert, additional, FitzGerald, J Mark, additional, Chapman, Kenneth R, additional, Boulet, Louis Philippe, additional, Bhutani, Mohit, additional, Sadatsafavi, Mohsen, additional, Jiménez-Maldonado, Libardo, additional, Duran-Silva, Mauricio, additional, Rodriguez, Bellanid, additional, Celis-Preciado, Carlos Andres, additional, Cano-Rosales, Diana Jimena, additional, Solarte, Ivan, additional, Fernandez- Sanchez, Maria Jose, additional, Parada-Tovar, Patricia, additional, von Bülow, Anna, additional, Bjerrum, Anne Sofie, additional, Ulrik, Charlotte S, additional, Assing, Karin Dahl, additional, Rasmussen, Linda Makowska, additional, Hansen, Susanne, additional, Altraja, Alan, additional, Bourdin, Arnaud, additional, Taille, Camille, additional, Charriot, Jeremy, additional, Roche, Nicolas, additional, Papaioannou, Andriana I, additional, Kostikas, Konstantinos, additional, Papadopoulos, Nikolaos G., additional, Salvi, Sundeep, additional, Long, Deirdre, additional, Mitchell, Patrick D, additional, Costello, Richard, additional, Sirena, Concetta, additional, Cardini, Cristina, additional, Heffler, Enrico, additional, Puggioni, Francesca, additional, Canonica, Giorgio Walter, additional, Guida, Giuseppe, additional, Iwanaga, Takashi, additional, Al-Ahmad, Mona, additional, García, Ulises, additional, Kuna, Piotr, additional, Fonseca, João A., additional, Al-Lehebi, Riyad, additional, Koh, Mariko S., additional, Rhee, Chin Kook, additional, Cosio, Borja G, additional, Perez de Llano, Luis, additional, Perng, Diahn-Warng, additional, Huang, Erick Wan-Chun, additional, Wang, Hao-Chien, additional, Tsai, Ming-Ju, additional, Mahboub, Bassam, additional, Salameh, Laila Ibraheem Jaber, additional, Jackson, David J., additional, Busby, John, additional, Heaney, Liam G, additional, Pfeffer, Paul E., additional, Goddard, Amanda Grippen, additional, Wang, Eileen, additional, Hoyte, Flavia C. L., additional, Chapman, Nicholas M, additional, Katial, Rohit, additional, Carter, Victoria, additional, Bulathsinhala, Lakmini, additional, Eleangovan, Neva, additional, Ariti, Con, additional, Lyu, Juntao, additional, Porsbjerg, Celeste, additional, and Price, David B., additional

Published
2023
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2. Diastolic Cardiomyopathy Secondary to Experimentally Induced Exacerbated Emphysema

Author

Grillet, Pierre-Edouard, primary, Desplanche, Elodie, additional, Wynands, Quentin, additional, Gouzi, Fares, additional, Bideaux, Patrice, additional, Fort, Aurelie, additional, Scheuermann, Valérie, additional, Lacampagne, Alain, additional, Virsolvy, Anne, additional, Thireau, Jérôme, additional, de Tombe, Pieter, additional, Bourdin, Arnaud, additional, and Cazorla, Olivier, additional

Published
2023
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3. Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma. A Delphi Study

Author

Suehs, Carey M, Menzies-Gow, Andrew, Price, David, Bleecker, Eugene R, Canonica, Giorgio Walter, Gurnell, Mark, Bourdin, Arnaud, Panel, Oral Corticosteroids Tapering Delphi Expert, Suehs, Carey M [0000-0002-2175-3496], Menzies-Gow, Andrew [0000-0001-9707-4986], Price, David [0000-0002-9728-9992], Bleecker, Eugene R [0000-0002-4767-3494], Canonica, Giorgio Walter [0000-0001-8467-2557], Gurnell, Mark [0000-0001-5745-6832], Bourdin, Arnaud [0000-0002-4645-5209], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, Consensus, Delphi Technique, shared decision-making, Administration, Oral, Middle Aged, Asthma, Drug Administration Schedule, biological treatments, Adrenal Cortex Hormones, Practice Guidelines as Topic, adverse effects, Humans, Female, adrenal insufficiency, Expert Testimony
Abstract

Rationale: There is a need to minimize oral corticosteroid (OCS) use in patients with asthma to prevent their costly and burdensome adverse effects. Current guidelines do not provide recommendations for OCS tapering in patients with asthma.Objectives: To develop expert consensus on OCS tapering among international experts.Methods: A modified Delphi method was used to develop expert consensus statements relating to OCS use, tapering, adverse effects, adrenal insufficiency, and patient-physician shared decision-making. Initial statements proposed by experts were categorized, filtered for repetition, and presented back to experts over three ranking rounds to obtain consensus (≥70% agreement).Measurements and Main Results: One hundred thirty-one international experts participated in the study, and 296 statements were ranked. Numerous recommendations and guidance regarding appropriate OCS use were established. Experts agreed that OCS tapering should be attempted in all patients with asthma receiving maintenance OCS therapy, with personalization of tapering rhythm and speed. The importance of recognizing individual adverse effects was also established; however, a unified approach to the assessment of adrenal insufficiency was not reached. Shared decision-making was considered an important goal during the tapering process.Conclusions: In this Delphi study, expert consensus statements were generated on OCS use, tapering, adverse-effect screening, and shared decision-making, which may be used to inform clinical practice. Areas of nonconsensus were identified, highlighting uncertainty among the experts around some aspects of OCS use in asthma, such as adrenal insufficiency, which underscores the need for further research in these domains.

Published
2021

4. Association between Initial Treatment Strategy and Long-Term Survival in Pulmonary Arterial Hypertension

Author

Boucly, Athénaïs, primary, Savale, Laurent, additional, Jaïs, Xavier, additional, Bauer, Fabrice, additional, Bergot, Emmanuel, additional, Bertoletti, Laurent, additional, Beurnier, Antoine, additional, Bourdin, Arnaud, additional, Bouvaist, Hélène, additional, Bulifon, Sophie, additional, Chabanne, Céline, additional, Chaouat, Ari, additional, Cottin, Vincent, additional, Dauphin, Claire, additional, Degano, Bruno, additional, De Groote, Pascal, additional, Favrolt, Nicolas, additional, Feng, Yuanchao, additional, Horeau-Langlard, Delphine, additional, Jevnikar, Mitja, additional, Jutant, Etienne-Marie, additional, Liang, Zhiying, additional, Magro, Pascal, additional, Mauran, Pierre, additional, Moceri, Pamela, additional, Mornex, Jean-François, additional, Palat, Sylvain, additional, Parent, Florence, additional, Picard, François, additional, Pichon, Jérémie, additional, Poubeau, Patrice, additional, Prévot, Grégoire, additional, Renard, Sébastien, additional, Reynaud-Gaubert, Martine, additional, Riou, Marianne, additional, Roblot, Pascal, additional, Sanchez, Olivier, additional, Seferian, Andrei, additional, Tromeur, Cécile, additional, Weatherald, Jason, additional, Simonneau, Gérald, additional, Montani, David, additional, Humbert, Marc, additional, and Sitbon, Olivier, additional

Published
2021
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6. Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial

Author

White, R. James, primary, Jerjes-Sanchez, Carlos, additional, Bohns Meyer, Gisela Martina, additional, Pulido, Tomas, additional, Sepulveda, Pablo, additional, Wang, Kuo Yang, additional, Grünig, Ekkehard, additional, Hiremath, Shirish, additional, Yu, Zaixin, additional, Gangcheng, Zhang, additional, Yip, Wei Luen James, additional, Zhang, Shuyang, additional, Khan, Akram, additional, Deng, C. Q., additional, Grover, Rob, additional, Tapson, Victor F., additional, Svetliza, Graciela Noemi, additional, Lescano, Adrian Jose, additional, Bortman, Guillermo Roberto, additional, Diez, Fabian Antonio, additional, Botta, Christian Edgardo, additional, Fitzgerald, John, additional, Feenstra, Eelke, additional, Kermeen, Fiona Dawn, additional, Keogh, Anne Margaret, additional, Williams, Trevor John, additional, Yousseff, Peter Paul, additional, Ng, Benjamin Joh-Han, additional, Smallwood, David McNaughton, additional, Dwyer, Nathan Brent, additional, Brown, Martin Russell, additional, Lang, Irene M, additional, Steringer-Mascherbauer, Regina, additional, Arakaki, Jaquelina Sonoe Ota, additional, Campos, Frederico Thadeu Assis Figueiredo, additional, de Amorim Correa, Ricardo, additional, de Souza, Rogerio, additional, Bohns Meyer, Gisela M., additional, Moreira, Maria Auxiliadora Carmo, additional, Yoo, Hugo Hyung Bok, additional, Lapa, Monica Silveira, additional, Swiston, John, additional, Hirani, Naushad, additional, Mehta, Sanjay, additional, Michelakis, Evangelos, additional, Sepulveda, Pablo Andres, additional, Blancaire, Monica Maria Zagolin, additional, Liu, Jimming, additional, Shuyang, Zhang, additional, Pan, Lei, additional, Chunde, Bao, additional, Qun, Yi, additional, Xiaoshu, Cheng, additional, Zaixin, Yu, additional, Li, Xinli, additional, Hua, Yao, additional, Zhu, Xianyang, additional, Chen, Yundai, additional, Zhaozhong, Cheng, additional, Yang, Yuanhua, additional, Daxin, Zhou, additional, Jieyan, Shen, additional, Nielsen-Kudsk, Jens Erik, additional, Carlsen, Jorn, additional, Bourdin, Arnaud, additional, Hachulla, Eric, additional, Dromer, Claire, additional, Chaouat, Ari, additional, Reynaud-Gauber, Martine, additional, Seronde, Marie-France, additional, Klose, Hans, additional, Halank, Michael, additional, Hoffken, Gert, additional, Ewert, Ralf, additional, Rosenkranz, Stephan, additional, Grunig, Ekkehard, additional, Kruger, Ulrich, additional, Kronsbein, Juliane, additional, Hauptmeier, Barbara Monika, additional, Koch, Andrea, additional, Held, Matthias, additional, Lange, Tobias Johannes, additional, Neurohr, Claus, additional, Wilkens, Heinrike, additional, Wilhelm Wirtz, Hubert Rolf, additional, Konstantinides, Stavros, additional, Argyropoulou-Pataka, Paraskevi, additional, Orfanos, Stylianos, additional, Kerkar, Prafulla Gopinath, additional, Suresh, Pujar Venkateshacharya, additional, Baxi, Hemang Ashwinkumar, additional, Oomman, Abraham, additional, Abhaichand, Rajpal Kanaklal, additional, Arjun, Padma Kumar Edla, additional, Chopra, Vijay, additional, Mehrotra, Rahul, additional, Rajput, Rajeev Kumar, additional, Sawhney, Jitendra Pal Singh, additional, Bimalendu, Subir, additional, Sharma, Kamal Harishchandra, additional, Sastry, Bhagavathula Kutumba Srinivasa, additional, Kramer, Mordechai Reuben, additional, Segel, Michael Jonathan, additional, Ben-Dov, Issahar, additional, Berkman, Neville, additional, Yigla, Mordechai, additional, Adir, Yochai, additional, D’Alto, Michael, additional, Vizza, Carmine Dario, additional, Scelsi, Laura, additional, Vitulo, Patrizio, additional, Pulido, Tomas Rene, additional, Boonstra, Anko, additional, Vonk, Madelon Clementina, additional, Sobkowicz, Bozena, additional, Mularek-Kubzdela, Tatiana, additional, Torbicki, Adam, additional, Podolec, Piotr, additional, Teik, Lim Soo, additional, Chang, Hyuk-Jae, additional, Kim, Hyung-Kwan, additional, Park, Jun-Bean, additional, Chang, Sung-A, additional, Kim, Duk-Kyung, additional, Chung, Wook-Jin, additional, Song, Jong-Min, additional, Nissell, Magnus, additional, Hjalmarsson, Clara, additional, Rundqvist, Bengt, additional, Huang, Wei-Chun, additional, Cheng, Chin-Chang, additional, Hsu, Chih-Hsin, additional, Hsu, Hsao-Hsun, additional, Wang, Kuo-Yang, additional, Coghlan, John Gerard, additional, Kiely, David Gerard, additional, Pepke-Zaba, Joanna Wanda, additional, Lordan, James Lawrence, additional, Corris, Paul Anthony, additional, Cadaret, Linda, additional, Hansdottir, Sif, additional, Oudiz, Ronald Jack, additional, Badesch, David B., additional, Mathier, Michael, additional, Schilz, Robert, additional, Hill, Nicholas, additional, Waxman, Aaron, additional, Markin, Catherine J., additional, Zwicke, Diane Lynn, additional, Fisher, Micah, additional, Franco, Veronica, additional, Sood, Namita, additional, Park, Myung H., additional, Allen, Roblee, additional, Feldman, Jeremy P., additional, Balasubramanian, Vijay, additional, Seeram, Vandana Kavita, additional, Bajwa, Abubakr, additional, Thompson, Austin B., additional, Migliore, Christina, additional, Elwing, Jean, additional, McConnell, John W., additional, Mehta, Jinesh P., additional, Rahaghi, Franck Farzad, additional, Rame, J. Eduardo, additional, Patel, Bela, additional, Oren, Ron M., additional, Klinger, James R., additional, Alnuaimat, Hassan, additional, Allen, Samuel, additional, Harvey, William, additional, Eggert, Michael S., additional, Hage, Antoine, additional, Miller, Chad E., additional, Awdish, Rana Lee Adawi, additional, Cajigas, Hector, additional, Grinnan, Daniel, additional, Trichon, Benjamin Howard, additional, McDonough, Clark, additional, White, R. James, additional, and Rischard, Franz, additional

Published
2020
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10. Bronchial Epithelial Calcium Metabolism Impairment in Smokers and Chronic Obstructive Pulmonary Disease. Decreased ORAI3 Signaling

Author

Petit, Aurelie, primary, Knabe, Lucie, additional, Khelloufi, Kamel, additional, Jory, Myriam, additional, Gras, Delphine, additional, Cabon, Yann, additional, Begg, Malcolm, additional, Richard, Sylvain, additional, Massiera, Gladys, additional, Chanez, Pascal, additional, Vachier, Isabelle, additional, and Bourdin, Arnaud, additional

Published
2019
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12. Poor Concordance between Sequential Transbronchial Lung Cryobiopsy and Surgical Lung Biopsy in the Diagnosis of Diffuse Interstitial Lung Diseases

Author

Romagnoli, Micaela, primary, Colby, Thomas V., additional, Berthet, Jean-Philippe, additional, Gamez, Anne Sophie, additional, Mallet, Jean-Pierre, additional, Serre, Isabelle, additional, Cancellieri, Alessandra, additional, Cavazza, Alberto, additional, Solovei, Laurence, additional, Dell’Amore, Andrea, additional, Dolci, Giampiero, additional, Guerrieri, Aldo, additional, Reynaud, Paul, additional, Bommart, Sébastien, additional, Zompatori, Maurizio, additional, Dalpiaz, Giorgia, additional, Nava, Stefano, additional, Trisolini, Rocco, additional, Suehs, Carey M., additional, Vachier, Isabelle, additional, Molinari, Nicolas, additional, and Bourdin, Arnaud, additional

Published
2019
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23. Pulmonary Hypertension In Patients Treated By Dasatinib

Author

Montani, David, primary, Bergot, Emmanuel, additional, Gunther, Sven, additional, Savale, Laurent, additional, Bergeron, Anne, additional, Bourdin, Arnaud, additional, Bouvaist, Helene, additional, Canuet, Matthieu, additional, Pison, Christophe, additional, Macro, Margareth, additional, Poubeau, Pascal, additional, Natali, Delphine, additional, Guignabert, Christophe, additional, Perros, Frederic, additional, Girerd, Barbara, additional, O'Callaghan, Dermot, additional, Jais, Xavier, additional, Tubert-Bitter, Pascale, additional, Zalcman, Gerard, additional, Sitbon, Olivier, additional, Simonneau, Gerald, additional, and Humbert, Marc J.C., additional

Published
2012
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28. Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma.

Author

Wechsler ME, Scelo G, Larenas-Linnemann DES, Torres-Duque CA, Maspero J, Tran TN, Murray RB, Martin N, Menzies-Gow AN, Hew M, Peters MJ, Gibson PG, Christoff GC, Popov TA, Côté A, Bergeron C, Dorscheid D, FitzGerald JM, Chapman KR, Boulet LP, Bhutani M, Sadatsafavi M, Jiménez-Maldonado L, Duran-Silva M, Rodriguez B, Celis-Preciado CA, Cano-Rosales DJ, Solarte I, Fernandez-Sanchez MJ, Parada-Tovar P, von Bülow A, Bjerrum AS, Ulrik CS, Assing KD, Rasmussen LM, Hansen S, Altraja A, Bourdin A, Taille C, Charriot J, Roche N, Papaioannou AI, Kostikas K, Papadopoulos NG, Salvi S, Long D, Mitchell PD, Costello R, Sirena C, Cardini C, Heffler E, Puggioni F, Canonica GW, Guida G, Iwanaga T, Al-Ahmad M, García U, Kuna P, Fonseca JA, Al-Lehebi R, Koh MS, Rhee CK, Cosio BG, Perez de Llano L, Perng DS, Huang EW, Wang HC, Tsai MJ, Mahboub B, Salameh LIJ, Jackson DJ, Busby J, Heaney LG, Pfeffer PE, Goddard AG, Wang E, Hoyte FCL, Chapman NM, Katial R, Carter V, Bulathsinhala L, Eleangovan N, Ariti C, Lyu J, Porsbjerg C, and Price DB

Subjects
Adult, Humans, Cohort Studies, Comorbidity, Chronic Disease, Rhinitis complications, Rhinitis drug therapy, Rhinitis epidemiology, Asthma complications, Asthma drug therapy, Asthma epidemiology, Sinusitis drug therapy, Sinusitis epidemiology, Biological Products therapeutic use, Rhinitis, Allergic complications, Rhinitis, Allergic drug therapy, Rhinitis, Allergic epidemiology, Nasal Polyps complications, Nasal Polyps drug therapy, Nasal Polyps epidemiology
Abstract

Rationale: Previous studies investigating the impact of comorbidities on the effectiveness of biologic agents have been relatively small and of short duration and have not compared classes of biologic agents. Objectives: To determine the association between type 2-related comorbidities and biologic agent effectiveness in adults with severe asthma (SA). Methods: This cohort study used International Severe Asthma Registry data from 21 countries (2017-2022) to quantify changes in four outcomes before and after biologic therapy-annual asthma exacerbation rate, FEV 1 % predicted, asthma control, and long-term oral corticosteroid daily dose-in patients with or without allergic rhinitis, chronic rhinosinusitis (CRS) with or without nasal polyps (NPs), NPs, or eczema/atopic dermatitis. Measurements and Main Results: Of 1,765 patients, 1,257, 421, and 87 initiated anti-IL-5/5 receptor, anti-IgE, and anti-IL-4/13 therapies, respectively. In general, pre- versus post-biologic therapy improvements were noted in all four asthma outcomes assessed, irrespective of comorbidity status. However, patients with comorbid CRS with or without NPs experienced 23% fewer exacerbations per year (95% CI, 10-35%; P  < 0.001) and had 59% higher odds of better post-biologic therapy asthma control (95% CI, 26-102%; P  < 0.001) than those without CRS with or without NPs. Similar estimates were noted for those with comorbid NPs: 22% fewer exacerbations and 56% higher odds of better post-biologic therapy control. Patients with SA and CRS with or without NPs had an additional FEV 1 % predicted improvement of 3.2% (95% CI, 1.0-5.3; P  = 0.004), a trend that was also noted in those with comorbid NPs. The presence of allergic rhinitis or atopic dermatitis was not associated with post-biologic therapy effect for any outcome assessed. Conclusions: These findings highlight the importance of systematic comorbidity evaluation. The presence of CRS with or without NPs or NPs alone may be considered a predictor of the effectiveness of biologic agents in patients with SA.

Published
2024
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29. Effects of inhaled corticosteroids on pathology in asthma and chronic obstructive pulmonary disease.

Author

Chanez P, Bourdin A, Vachier I, Godard P, Bousquet J, and Vignola AM

Subjects
Administration, Inhalation, Airway Resistance drug effects, Biopsy, Needle, Bronchoscopy, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Immunohistochemistry, Male, Prognosis, Risk Assessment, Severity of Illness Index, Treatment Outcome, Adrenal Cortex Hormones administration & dosage, Asthma drug therapy, Asthma pathology, Pulmonary Disease, Chronic Obstructive drug therapy, Pulmonary Disease, Chronic Obstructive pathology
Abstract

The effects of inhaled corticosteroids (ICSs) have been investigated in asthma and chronic obstructive pulmonary disease (COPD) using endobronchial biopsies. In asthma, most studies have shown reductions in infiltrating eosinophils, mast cells, and T lymphocytes. Cell-associated mediators, such as cytokines derived from type 2 T-helper lymphocytes, are decreased as assessed by immunostaining and molecular biology techniques. More recently, attention has been devoted to the effect of ICSs on structural changes. In asthma, ICSs have been shown in some studies to affect collagen deposition (size of the reticular basement membrane), the number of vessels, or epithelial integrity. The correlations between those findings and various clinical and functional outcomes are far from clear. A long-term study has shown a decrease in the basement membrane size in a group of patients with asthma treated according to their level of airway hyperreactivity. In COPD, ICSs generally do not decrease neutrophils, macrophages, and CD8(+) T lymphocytes. The effects of these drugs on structural changes in COPD have not been investigated extensively. Long-term prospective studies are needed to demonstrate the potential for ICSs to affect the natural history of chronic bronchial diseases.

Published
2004
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