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Your search keyword '"Mou, Hongmei"' showing total 7 results
Start Over Author "Mou, Hongmei" Publisher american thoracic society
7 results on '"Mou, Hongmei"'

1. Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation

Author

Bankoti, Kamakshi, primary, Wang, Wei, additional, Amonkar, Gaurang M, additional, Xiong, Linjie, additional, Shui, Jessica E, additional, Zhao, Caiqi, additional, Van, Eric, additional, Mwase, Chimwemwe, additional, Park, Jin-Ah, additional, Mou, Hongmei, additional, Fang, Yinshan, additional, Que, Jianwen, additional, Bai, Yan, additional, Lerou, Paul H, additional, and Ai, Xingbin, additional

Published
2023
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2. Basal Cell–derived WNT7A Promotes Fibrogenesis at the Fibrotic Niche in Idiopathic Pulmonary Fibrosis

Author

Huang, Guanling, primary, Liang, Jiurong, additional, Huang, Kevin, additional, Liu, Xue, additional, Taghavifar, Forough, additional, Yao, Changfu, additional, Parimon, Tanyalak, additional, Liu, Ningshan, additional, Dai, Kristy, additional, Aziz, Adam, additional, Wang, Yizhou, additional, Waldron, Richard T., additional, Mou, Hongmei, additional, Stripp, Barry, additional, Noble, Paul W., additional, and Jiang, Dianhua, additional

Published
2023
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3. Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity

Author

Zhang, Yihan, primary, Black, Katharine Elliot, additional, Phung, Thien-Khoi N, additional, Thundivalappil, Sujatha Rajeev, additional, Lin, Tian, additional, Wang, Wei, additional, Xu, Jie, additional, Zhang, Cheng, additional, Hariri, Lida P, additional, Lapey, Allen, additional, Li, Hu, additional, Lerou, Paul Hubert, additional, Ai, Xingbin, additional, Que, Jianwen, additional, Park, Jin-Ah, additional, Hurley, Bryan P, additional, and Mou, Hongmei, additional

Published
2023
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5. Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells

Author

Hao, Yuan, primary, Bates, Samuel, additional, Mou, Hongmei, additional, Yun, Jeong H., additional, Pham, Betty, additional, Liu, Jiangyuan, additional, Qiu, Weiliang, additional, Guo, Feng, additional, Morrow, Jarrett D., additional, Hersh, Craig P., additional, Benway, Christopher J., additional, Gong, Lu, additional, Zhang, Yihan, additional, Rosas, Ivan O., additional, Cho, Michael H., additional, Park, Jin-Ah, additional, Castaldi, Peter J., additional, Du, Fei, additional, and Zhou, Xiaobo, additional

Published
2020
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7. Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation.

Author

Bankoti K, Wang W, Amonkar GM, Xiong L, Shui JE, Zhao C, Van E, Mwase C, Park JA, Mou H, Fang Y, Que J, Bai Y, Lerou PH, and Ai X

Subjects
Humans, Stem Cells, Cell Differentiation physiology, Bronchi, Epithelial Cells, COVID-19
Abstract

Airway basal stem cells (BSCs) play a critical role in epithelial regeneration. Whether coronavirus disease (COVID-19) affects BSC function is unknown. Here, we derived BSC lines from patients with COVID-19 using tracheal aspirates (TAs) to circumvent the biosafety concerns of live-cell derivation. We show that BSCs derived from the TAs of control patients are bona fide bronchial BSCs. TA BSCs from patients with COVID-19 tested negative for severe acute respiratory syndrome coronavirus 2 RNA; however, these so-termed COVID-19-exposed BSCs in vitro resemble a predominant BSC subpopulation uniquely present in patients with COVID-19, manifested by a proinflammatory gene signature and STAT3 hyperactivation. Furthermore, the sustained STAT3 hyperactivation drives goblet cell differentiation of COVID-19-exposed BSCs in an air-liquid interface. Last, these phenotypes of COVID-19-exposed BSCs can be induced in control BSCs by cytokine cocktail pretreatment. Taken together, acute inflammation in COVID-19 exerts a long-term impact on mucociliary differentiation of BSCs.

Published
2024
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