Search

Your search keyword '"SEKIZAWA, KIYOHISA"' showing total 19 results
Start Over Author "SEKIZAWA, KIYOHISA" Publisher american thoracic society
19 results on '"SEKIZAWA, KIYOHISA"'

1. Transcription Factors T-bet and GATA-3 Regulate Development of Airway Remodeling

Author

Kiwamoto, Takumi, primary, Ishii, Yukio, additional, Morishima, Yuko, additional, Yoh, Keigyou, additional, Maeda, Atsuko, additional, Ishizaki, Kazusa, additional, Iizuka, Takashi, additional, Hegab, Ahmed E., additional, Matsuno, Yosuke, additional, Homma, Shinsuke, additional, Nomura, Akihiro, additional, Sakamoto, Tohru, additional, Takahashi, Satoru, additional, and Sekizawa, Kiyohisa, additional

Published
2006
Full Text
View/download PDF

2. Role of 15-DeoxyΔ12,14 Prostaglandin J2 and Nrf2 Pathways in Protection against Acute Lung Injury

Author

Mochizuki, Mie, primary, Ishii, Yukio, additional, Itoh, Ken, additional, Iizuka, Takashi, additional, Morishima, Yuko, additional, Kimura, Toru, additional, Kiwamoto, Takumi, additional, Matsuno, Yosuke, additional, Hegab, Ahamed E., additional, Nomura, Akihiro, additional, Sakamoto, Tohru, additional, Uchida, Koji, additional, Yamamoto, Masayuki, additional, and Sekizawa, Kiyohisa, additional

Published
2005
Full Text
View/download PDF

8. Triggering the Induction of Myofibroblast and Fibrogenesis by Airway Epithelial Shedding

Author

Morishima, Yuko, primary, Nomura, Akihiro, additional, Uchida, Yoshiyuki, additional, Noguchi, Yoshiko, additional, Sakamoto, Tohru, additional, Ishii, Yukio, additional, Goto, Yukio, additional, Masuyama, Kuniko, additional, Zhang, Min Jie, additional, Hirano, Kuniyoshi, additional, Mochizuki, Mie, additional, Ohtsuka, Morio, additional, and Sekizawa, Kiyohisa, additional

Published
2001
Full Text
View/download PDF

19. Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury.

Author

Mochizuki M, Ishii Y, Itoh K, Iizuka T, Morishima Y, Kimura T, Kiwamoto T, Matsuno Y, Hegab AE, Nomura A, Sakamoto T, Uchida K, Yamamoto M, and Sekizawa K

Subjects
Animals, Carrageenan, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors therapeutic use, Disease Models, Animal, Macrophages metabolism, Mice, Mice, Inbred BALB C, NF-E2-Related Factor 2, Nitrobenzenes therapeutic use, Pneumonia drug therapy, Pneumonia etiology, Pneumonia metabolism, Prostaglandin-Endoperoxide Synthases metabolism, Respiratory Distress Syndrome chemically induced, Respiratory Distress Syndrome complications, Respiratory Distress Syndrome drug therapy, Respiratory Distress Syndrome immunology, Sulfonamides therapeutic use, DNA-Binding Proteins metabolism, Prostaglandin D2 analogs & derivatives, Prostaglandin D2 metabolism, Respiratory Distress Syndrome metabolism, Trans-Activators metabolism
Abstract

Rationale: Acute lung injury (ALI) is a disease process that is characterized by diffuse inflammation in the lung parenchyma. Recent studies demonstrated that cyclooxygenase-2 (COX-2) induced at the late phase of inflammation aids in the resolution of inflammation by generating 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2). Transcription factor Nrf2 is activated by electrophiles and exerts antiinflammatory effects by inducing the gene expression of antioxidant and detoxification enzymes., Objectives: Because 15d-PGJ2 is an endogenous electrophile, we hypothesized that it protects against ALI by activating Nrf2., Methods: To test this hypothesis, we generated a reversible ALI model by intratracheal injection of carrageenin, an inducer of acute inflammation, whose stimulation has been known to induce COX-2., Main Results: We found that ALI induced by carrageenin was markedly exacerbated in Nrf2-knockout mice, compared with wild-type mice. Analysis of bronchoalveolar lavage fluids also revealed that the magnitude and the duration of acute inflammation, indicated by albumin concentration and the number of neutrophils, were significantly enhanced in Nrf2-knockout mice. Treatment of wild-type mice with NS-398, a selective COX-2 inhibitor, significantly exacerbated ALI to the level of Nrf2-knockout mice. In the lungs of NS-398-treated wild-type mice, both the accumulation of 15d-PGJ2 and the induction of Nrf2 target antioxidant genes were significantly attenuated. Exogenous administration of 15d-PGJ2 reversed the exacerbating effects of NS-398 with the induction of antioxidant genes., Conclusions: These results demonstrated in vivo that 15d-PGJ2 plays a protective role against ALI by exploiting the Nrf2-mediated transcriptional pathway.

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results