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254 results on '"Sin, Don D"'

1. Leveraging CT Imaging to Detect COPD and Concomitant Chronic Diseases

Author

Labaki, Wassim W., primary, Agusti, Alvar, additional, Bhatt, Surya P, additional, Bodduluri, Sandeep, additional, Criner, Gerard J., additional, Fabbri, Leonardo M, additional, Halpin, David M.G., additional, Lynch, David A., additional, Mannino, David M., additional, Miravitlles, Marc, additional, Papi, Alberto, additional, Sin, Don D, additional, Washko, George R, additional, Kazerooni, Ella A., additional, and Han, MeiLan K., additional

Published
2024
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2. Best in Class: IgG as a Treatable Trait for Exacerbation Prevention in Chronic Obstructive Pulmonary Disease.

Author

Wang, Carolyn J. and Sin, Don D.

Subjects
RESPIRATORY infections, CHRONIC obstructive pulmonary disease, DENDRITIC cells, DISEASE exacerbation, DISEASE relapse
Abstract

The editorial discusses the potential of IgG deficiency as a treatable trait for preventing exacerbations in Chronic Obstructive Pulmonary Disease (COPD). Studies have shown that patients with COPD are at a higher risk of exacerbations due to viral and bacterial infections, with IgG deficiency being associated with more severe exacerbations and hospitalizations. Recent research suggests that IgG replacement therapy could reduce the frequency and severity of COPD exacerbations, although further studies are needed to confirm its effectiveness. The study highlights the importance of understanding the role of IgG and its subclasses in COPD pathology and the potential for IgG replacement therapy as a treatment option. [Extracted from the article]

Published
2025
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3. What Harm Are We Doing to Our Patients with Asthma by Using High-Dose Inhaled Corticosteroids?

Author

Sin, Don D. and Busse, William W.

Subjects
CHRONIC obstructive pulmonary disease, MAJOR adverse cardiovascular events, ASTHMA in children, ASTHMATICS, MEDICAL research
Abstract

The editorial discusses the potential harm caused to asthma patients by using high-dose inhaled corticosteroids (ICSs). While ICSs are effective in controlling asthma symptoms, they can lead to serious adverse effects, especially at higher doses. A study by Bloom and colleagues found that medium to high doses of ICSs significantly increased the risk of cardiovascular events, pulmonary embolism, and pneumonia, with the highest risk associated with high-dose ICSs. The study suggests that high-dose ICSs, especially over the long term, should be avoided, and emphasizes the importance of step-back or step-down strategies in asthma management. [Extracted from the article]

Published
2025
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4. Normative Reference Equations for Breathlessness Intensity during Incremental Cardiopulmonary Cycle Exercise Testing

Author

Ekström, Magnus, primary, Li, Pei Zhi, additional, Lewthwaite, Hayley, additional, Bourbeau, Jean, additional, Tan, Wan C., additional, Schiöler, Linus, additional, Brotto, Andrew, additional, Stickland, Michael K., additional, Jensen, Dennis, additional, FitzGerald, J. Mark, additional, Sin, Don D., additional, Marciniuk, Darcy D., additional, O’Donnell, Denis E., additional, Hernandez, Paul, additional, Chapman, Kenneth R., additional, Walker, Brandie, additional, Aaron, Shawn, additional, Maltais, François, additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Doiron, Dany, additional, Mancino, Palmina, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Kirby, Miranda, additional, Sadatsafavi, Mohsen, additional, To, Teresa, additional, Gershon, Andrea, additional, Song, Zhi, additional, Benedetti, Andrea, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonte, Laura, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candice, additional

Published
2024
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5. Leveraging Computed Tomography Imaging to Detect Chronic Obstructive Pulmonary Disease and Concomitant Chronic Diseases.

Author

Labaki, Wassim W., Agusti, Alvar, Bhatt, Surya P., Bodduluri, Sandeep, Criner, Gerard J., Fabbri, Leonardo M., Halpin, David M. G., Lynch, David A., Mannino, David M., Miravitlles, Marc, Papi, Alberto, Sin, Don D., Washko, George R., Kazerooni, Ella A., and Han, MeiLan K.

Subjects
CHRONIC obstructive pulmonary disease, COMPUTED tomography, DISEASE complications, BRONCHIECTASIS, INTERSTITIAL lung diseases, COMORBIDITY, OBSTRUCTIVE lung diseases
Abstract

The article addresses the global impact of chronic obstructive pulmonary disease (COPD), noting its high prevalence and the significant burden of undiagnosed cases. Topics include the limitations of current screening practices and the U.S. Preventive Services Task Force's stance against routine spirometry for asymptomatic individuals, despite evidence suggesting that at-risk populations could benefit from early detection.

Published
2024
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7. Why Is Body Mass Index Related to Chronic Obstructive Pulmonary Disease? Is It All in the Genes?

Author

Hernández Cordero, Ana I. and Sin, Don D.

Subjects
GENETIC risk score, OBSTRUCTIVE lung diseases, CHRONIC obstructive pulmonary disease, SMOKING, CLINICAL trials, EXERCISE tolerance
Abstract

Chronic obstructive pulmonary disease (COPD) affects millions of people worldwide and is a leading cause of death. While the exact causes of COPD are not fully understood, it is believed to be influenced by both genetic and environmental factors. Low body mass index (BMI) is a significant risk factor for rapid disease progression in COPD patients, while high BMI is associated with increased risks of all-cause mortality and cardiovascular deaths. Researchers have developed prognostic models, such as the BODE index, to predict mortality risk in COPD patients using BMI and other health metrics. A recent study investigated the relationship between genetically predicted BMI and mortality in COPD patients and found that differences between measured and genetically predicted BMI were associated with increased risks of all-cause and respiratory mortality. These findings suggest that genetic determinants of BMI could be used as biomarkers for mortality risk in COPD patients and may inform interventions to modify prognosis. However, the study has limitations, including its focus on populations of European ancestry and the need for further research to establish causality and clinical translation. Overall, this study contributes to our understanding of the genetic factors influencing BMI and their role in COPD. [Extracted from the article]

Published
2024
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9. Blood Gene Expression and Immune Cell Subtypes Associated with COPD Exacerbations

Author

Ryu, Min Hyung, primary, Yun, Jeong H, additional, Morrow, Jarrett D, additional, Saferali, Aabida, additional, Castaldi, Peter, additional, Chase, Robert, additional, Stav, Meryl, additional, Xu, Zhonghui, additional, Barjaktarevic, Igor, additional, Han, MeiLan, additional, Labaki, Wassim, additional, Huang, Yvonne J, additional, Christenson, Stephanie, additional, O'Neal, Wanda, additional, Bowler, Russell, additional, Sin, Don D, additional, Freeman, Christine M, additional, Curtis, Jeffrey L, additional, and Hersh, Craig P., additional

Published
2023
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10. Blood-based Transcriptomic and Proteomic Biomarkers of Emphysema.

Author

Suryadevara, Rahul, Gregory, Andrew, Lu, Robin, Zhonghui Xu, Masoomi, Aria, Lutz, Sharon M., Berman, Seth, Yun, Jeong H., Saferali, Aabida, Min Hyung Ryu, Moll, Matthew, Sin, Don D., Hersh, Craig P., Silverman, Edwin K., Dy, Jennifer, Pratte, Katherine A., Bowler, Russell P., Castaldi, Peter J., and Boueiz, Adel

Subjects
RECEIVER operating characteristic curves, PROTEOMICS, BIOMARKERS, ALTERNATIVE RNA splicing, CHRONIC obstructive pulmonary disease
Abstract

Rationale: Emphysema is a chronic obstructive pulmonary disease phenotype with important prognostic implications. Identifying blood-based biomarkers of emphysema will facilitate early diagnosis and development of targeted therapies. Objectives: To discover blood omics biomarkers for chest computed tomography-quantified emphysema and develop predictive biomarker panels. Methods: Emphysema blood biomarker discovery was performed using differential gene expression, alternative splicing, and protein association analyses in a training sample of 2,370 COPDGene participants with available blood RNA sequencing, plasma proteomics, and clinical data. Internal validation was conducted in a COPDGene testing sample (n = 1,016), and external validation was done in the ECLIPSE study (n = 526). Because low body mass index (BMI) and emphysema often co-occur, we performed a mediation analysis to quantify the effect of BMI on gene and protein associations with emphysema. Elastic net models with bootstrapping were also developed in the training sample sequentially using clinical, blood cell proportions, RNA-sequencing, and proteomic biomarkers to predict quantitative emphysema. Model accuracy was assessed by the area under the receiver operating characteristic curves for subjects stratified into tertiles of emphysema severity. Measurements and Main Results: Totals of 3,829 genes, 942 isoforms, 260 exons, and 714 proteins were significantly associated with emphysema (false discovery rate, 5%) and yielded 11 biological pathways. Seventy-four percent of these genes and 62% of these proteins showed mediation by BMI. Our prediction models demonstrated reasonable predictive performance in both COPDGene and ECLIPSE. The highest-performing model used clinical, blood cell, and protein data (area under the receiver operating characteristic curve in COPDGene testing, 0.90; 95% confidence interval, 0.85-0.90). Conclusions: Blood transcriptome and proteome-wide analyses revealed key biological pathways of emphysema and enhanced the prediction of emphysema. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary

Author

Agustí, Alvar, primary, Celli, Bartolome R., additional, Criner, Gerard J., additional, Halpin, David, additional, Anzueto, Antonio, additional, Barnes, Peter, additional, Bourbeau, Jean, additional, Han, MeiLan K., additional, Martinez, Fernando J., additional, Montes de Oca, Maria, additional, Mortimer, Kevin, additional, Papi, Alberto, additional, Pavord, Ian, additional, Roche, Nicolas, additional, Salvi, Sundeep, additional, Sin, Don D., additional, Singh, Dave, additional, Stockley, Robert, additional, López Varela, M. Victorina, additional, Wedzicha, Jadwiga A., additional, and Vogelmeier, Claus F., additional

Published
2023
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13. Blood Gene Expression and Immune Cell Subtypes Associated with Chronic Obstructive Pulmonary Disease Exacerbations.

Author

Min Hyung Ryu, Yun, Jeong H., Morrow, Jarrett D., Saferali, Aabida, Castaldi, Peter, Chase, Robert, Stav, Meryl, Zhonghui Xu, Barjaktarevic, Igor, Han, MeiLan, Labaki, Wassim, Huang, Yvonne J., Christenson, Stephanie, O’Neal, Wanda, Bowler, Russell, Sin, Don D., Freeman, Christine M., Curtis, Jeffrey L., and Hersh, Craig P.

Abstract

Rationale: Acute exacerbations of chronic obstructive pulmonary disease (AE-COPDs) are associated with a significant disease burden. Blood immune phenotyping may improve our understanding of a COPD endotype at increased risk of exacerbations. Objective: To determine the relationship between the transcriptome of circulating leukocytes and COPD exacerbations. Methods: Blood RNA sequencing data (n = 3,618) from the COPDGene (Genetic Epidemiology of COPD) study were analyzed. Blood microarray data (n = 646) from the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) study were used for validation. We tested the association between blood gene expression and AE-COPDs. We imputed the abundance of leukocyte subtypes and tested their association with prospective AE-COPDs. Flow cytometry was performed on blood in SPIROMICS (Subpopulations and Intermediate Outcomes in COPD Study) (n = 127), and activation markers for T cells were tested for association with prospective AE-COPDs. Measurements and Main Results: Exacerbations were reported 4,030 and 2,368 times during follow-up in COPDGene (5.3 ± 1.7 yr) and ECLIPSE (3 yr), respectively. We identified 890, 675, and 3,217 genes associated with a history of AE-COPDs, persistent exacerbations (at least one exacerbation per year), and prospective exacerbation rate, respectively. In COPDGene, the number of prospective exacerbations in patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stage ⩾2) was negatively associated with circulating CD8+ T cells, CD4+ T cells, and resting natural killer cells. The negative association with naive CD4+ T cells was replicated in ECLIPSE. In the flow-cytometry study, an increase in CTLA4 on CD4+ T cells was positively associated with AE-COPDs. Conclusions: Individuals with COPD with lower circulating lymphocyte counts, particularly decreased CD4+ T cells, are more susceptible to AE-COPDs, including persistent exacerbations. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Syndrome of Combined Pulmonary Fibrosis and Emphysema: An Official ATS/ERS/JRS/ALAT Research Statement

Author

Cottin, Vincent, primary, Selman, Moises, additional, Inoue, Yoshikazu, additional, Wong, Alyson W., additional, Corte, Tamera J., additional, Flaherty, Kevin R., additional, Han, MeiLan K., additional, Jacob, Joseph, additional, Johannson, Kerri A., additional, Kitaichi, Masanori, additional, Lee, Joyce S., additional, Agusti, Alvar, additional, Antoniou, Katerina M., additional, Bianchi, Pauline, additional, Caro, Fabian, additional, Florenzano, Matias, additional, Galvin, Liam, additional, Iwasawa, Tae, additional, Martinez, Fernando J., additional, Morgan, Rebecca L., additional, Myers, Jeffrey L., additional, Nicholson, Andrew G., additional, Occhipinti, Mariaelena, additional, Poletti, Venerino, additional, Salisbury, Margaret L., additional, Sin, Don D., additional, Sverzellati, Nicola, additional, Tonia, Thomy, additional, Valenzuela, Claudia, additional, Ryerson, Christopher J., additional, and Wells, Athol U., additional

Published
2022
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15. Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease

Author

Hernández Cordero, Ana I., primary, Yang, Chen Xi, additional, Yang, Julia, additional, Horvath, Steve, additional, Shaipanich, Tawimas, additional, MacIsaac, Julia, additional, Lin, David T. S., additional, Kobor, Michael S., additional, Guillemi, Silvia, additional, Harris, Marianne, additional, Lam, Wan, additional, Lam, Stephen, additional, Montaner, Julio, additional, Man, S. F. Paul, additional, Sin, Don D., additional, and Leung, Janice M., additional

Published
2022
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16. Ambient Air Pollution and Dysanapsis: Associations with Lung Function and Chronic Obstructive Pulmonary Disease in the Canadian Cohort Obstructive Lung Disease Study

Author

Bourbeau, Jean, primary, Doiron, Dany, additional, Biswas, Sharmistha, additional, Smith, Benjamin M., additional, Benedetti, Andrea, additional, Brook, Jeffrey R., additional, Aaron, Shawn D., additional, Chapman, Kenneth R., additional, Hernandez, Paul, additional, Maltais, François, additional, Marciniuk, Darcy D., additional, O’Donnell, Denis, additional, Sin, Don D., additional, Walker, Brandie, additional, Dsilva, Liesel, additional, Nadeau, Gilbert, additional, Coats, Valérie, additional, Compton, Chris, additional, Miller, Bruce E., additional, Tan, Wan C., additional, Bourbeau, Jean, additional, FitzGerald, J. Mark, additional, O’Donnell, Denis E., additional, Aaron, Shawn, additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Mancino, Palmina, additional, Li, Pei Zhi, additional, Jensen, Dennis, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Kirby, Miranda, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Sadatsafavi, Mohsen, additional, To, Teresa, additional, Gershon, Andrea, additional, Song, Zhi, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonté, Laura, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, Vincent, Sandra, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candice, additional

Published
2022
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17. Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease

Author

Moll, Matthew, primary, Boueiz, Adel, additional, Ghosh, Auyon J., additional, Saferali, Aabida, additional, Lee, Sool, additional, Xu, Zhonghui, additional, Yun, Jeong H., additional, Hobbs, Brian D., additional, Hersh, Craig P., additional, Sin, Don D., additional, Tal-Singer, Ruth, additional, Silverman, Edwin K., additional, Cho, Michael H., additional, Castaldi, Peter J., additional, Crapo, James D., additional, Make, Barry J., additional, Regan, Elizabeth A., additional, Beaty, Terri, additional, Begum, Ferdouse, additional, Cho, Michael, additional, DeMeo, Dawn L., additional, Boueiz, Adel R., additional, Foreman, Marilyn G., additional, Halper-Stromberg, Eitan, additional, Hayden, Lystra P., additional, Hetmanski, Jacqueline, additional, Hokanson, John E., additional, Laird, Nan, additional, Lange, Christoph, additional, Lutz, Sharon M., additional, McDonald, Merry-Lynn, additional, Parker, Margaret M., additional, Prokopenko, Dmitry, additional, Qiao, Dandi, additional, Sakornsakolpat, Phuwanat, additional, Wan, Emily S., additional, Centeno, Juan Pablo, additional, Charbonnier, Jean-Paul, additional, Coxson, Harvey O., additional, Galban, Craig J., additional, Han, MeiLan K., additional, Hoffman, Eric A., additional, Humphries, Stephen, additional, Jacobson, Francine L., additional, Judy, Philip F., additional, Kazerooni, Ella A., additional, Kluiber, Alex, additional, Lynch, David A., additional, Nardelli, Pietro, additional, Newell, John D., additional, Notary, Aleena, additional, Oh, Andrea, additional, Ross, James C., additional, San Jose Estepar, Raul, additional, Schroeder, Joyce, additional, Sieren, Jered, additional, Stoel, Berend C., additional, Tschirren, Juerg, additional, Van Beek, Edwin, additional, van Ginneken, Bram, additional, van Rikxoort, Eva, additional, Vegas Sanchez-Ferrero, Gonzalo, additional, Veitel, Lucas, additional, Washko, George R., additional, Wilson, Carla G., additional, Jensen, Robert, additional, Everett, Douglas, additional, Crooks, Jim, additional, Pratte, Katherine, additional, Strand, Matt, additional, Kinney, Gregory, additional, Young, Kendra A., additional, Bhatt, Surya P., additional, Bon, Jessica, additional, Diaz, Alejandro A., additional, Murray, Susan, additional, Soler, Xavier, additional, Bowler, Russell P., additional, Kechris, Katerina, additional, and Banaei-Kashani, Farnoush, additional

Published
2022
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18. Computed Tomography Vascular Tree-in-Bud: A Novel Prognostic Imaging Biomarker in COVID-19?

Author

Eddy, Rachel L. and Sin, Don D.

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, 2019-20 coronavirus outbreak, medicine.diagnostic_test, Coronavirus disease 2019 (COVID-19), Imaging biomarker, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Editorials, Computed tomography, Critical Care and Intensive Care Medicine, Tree (data structure), Medicine, Radiology, business, Coronavirus Infections
Published
2020
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19. Effects of Inhaled Corticosteroid/Long-Acting β2-Agonist Combination on the Airway Microbiome of Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Clinical Trial (DISARM)

Author

Leitao Filho, Fernando Sergio, primary, Takiguchi, Hiroto, additional, Akata, Kentaro, additional, Ra, Seung Won, additional, Moon, Ji-Yong, additional, Kim, Hyun Kuk, additional, Cho, Yuji, additional, Yamasaki, Kei, additional, Milne, Stephen, additional, Yang, Julia, additional, Yang, Cheng Wei Tony, additional, Li, Xuan, additional, Nislow, Corey, additional, van Eeden, Stephan F., additional, Shaipanich, Tawimas, additional, Lam, Stephen, additional, Leung, Janice M., additional, and Sin, Don D., additional

Published
2021
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20. Personal Interventions for Reducing Exposure and Risk for Outdoor Air Pollution: An Official American Thoracic Society Workshop Report

Author

Laumbach, Robert J., primary, Cromar, Kevin R., additional, Adamkiewicz, Gary, additional, Carlsten, Christopher, additional, Charpin, Denis, additional, Chan, Wanyu R., additional, de Nazelle, Audrey, additional, Forastiere, Francesco, additional, Goldstein, Jeffrey, additional, Gumy, Sophie, additional, Hallman, William K., additional, Jerrett, Michael, additional, Kipen, Howard M., additional, Pirozzi, Cheryl S., additional, Polivka, Barbara J., additional, Radbel, Jared, additional, Shaffer, Ronald E., additional, Sin, Don D., additional, and Viegi, Giovanni, additional

Published
2021
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23. Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease.

Author

Cordero, Ana I. Hernández, Chen Xi Yang, Julia Yang, Horvath, Steve, Shaipanich, Tawimas, MacIsaac, Julia, Lin, David T. S., Kobor, Michael S., Guillemi, Silvia, Harris, Marianne, Wan Lam, Lam, Stephen, Montaner, Julio, Man, S. F. Paul, Sin, Don D., Leung, Janice M., Hernández Cordero, Ana I, Yang, Chen Xi, Yang, Julia, and Lam, Wan

Subjects
HIV infection complications, HIV infections, DNA methylation, OBSTRUCTIVE lung diseases, AGING, RESEARCH funding, EPIGENOMICS, DISEASE complications
Abstract

Rationale: Age-related diseases like chronic obstructive pulmonary disease (COPD) occur at higher rates in people living with human immunodeficiency virus (PLWH) than in uninfected populations. Objectives: To identify whether accelerated aging can be observed in the airways of PLWH with COPD, manifest by a unique DNA methylation signature. Methods: Bronchial epithelial brushings from PLWH with and without COPD and HIV-uninfected adults with and without COPD (N = 76) were profiled for DNA methylation and gene expression. We evaluated global Alu and LINE-1 methylation and calculated the epigenetic age using the Horvath clock and the methylation telomere length estimator. To identify genome-wide differential DNA methylation and gene expression associated with HIV and COPD, robust linear models were used followed by an expression quantitative trait methylation (eQTM) analysis. Measurements and Main Results: Epigenetic age acceleration and shorter methylation estimates of telomere length were found in PLWH with COPD compared with PLWH without COPD and uninfected patients with and without COPD. Global hypomethylation was identified in PLWH. We identified 7,970 cytosine bases located next to a guanine base (CpG sites), 293 genes, and 9 expression quantitative trait methylation-gene pairs associated with the interaction between HIV and COPD. Actin binding LIM protein family member 3 (ABLIM3) was one of the novel candidate genes for HIV-associated COPD highlighted by our analysis. Conclusions: Methylation age acceleration is observed in the airway epithelium of PLWH with COPD, a process that may be responsible for the heightened risk of COPD in this population. Their distinct methylation profile, differing from that observed in patients with COPD alone, suggests a unique pathogenesis to HIV-associated COPD. The associations warrant further investigation to establish causality. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Pharmacologic Management of Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline

Author

Nici, Linda, primary, Mammen, Manoj J., additional, Charbek, Edward, additional, Alexander, Paul E., additional, Au, David H., additional, Boyd, Cynthia M., additional, Criner, Gerard J., additional, Donaldson, Gavin C., additional, Dreher, Michael, additional, Fan, Vincent S., additional, Gershon, Andrea S., additional, Han, MeiLan K., additional, Krishnan, Jerry A., additional, Martinez, Fernando J., additional, Meek, Paula M., additional, Morgan, Michael, additional, Polkey, Michael I., additional, Puhan, Milo A., additional, Sadatsafavi, Mohsen, additional, Sin, Don D., additional, Washko, George R., additional, Wedzicha, Jadwiga A., additional, and Aaron, Shawn D., additional

Published
2020
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26. Computed Tomography Total Airway Count Is Associated with the Number of Micro–Computed Tomography Terminal Bronchioles

Author

Kirby, Miranda, primary, Tanabe, Naoya, additional, Vasilescu, Dragoş M., additional, Cooper, Joel D., additional, McDonough, John E., additional, Verleden, Stijn E., additional, Vanaudenaerde, Bart M., additional, Sin, Don D., additional, Tan, Wan C., additional, Coxson, Harvey O., additional, and Hogg, James C., additional

Published
2020
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27. Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

Author

Allen, Richard J., primary, Guillen-Guio, Beatriz, additional, Oldham, Justin M., additional, Ma, Shwu-Fan, additional, Dressen, Amy, additional, Paynton, Megan L., additional, Kraven, Luke M., additional, Obeidat, Ma'en, additional, Li, Xuan, additional, Ng, Michael, additional, Braybrooke, Rebecca, additional, Molina-Molina, Maria, additional, Hobbs, Brian D., additional, Putman, Rachel K., additional, Sakornsakolpat, Phuwanat, additional, Booth, Helen L., additional, Fahy, William A., additional, Hart, Simon P., additional, Hill, Mike R., additional, Hirani, Nik, additional, Hubbard, Richard B., additional, McAnulty, Robin J., additional, Millar, Ann B., additional, Navaratnam, Vidyia, additional, Oballa, Eunice, additional, Parfrey, Helen, additional, Saini, Gauri, additional, Whyte, Moira K. B., additional, Zhang, Yingze, additional, Kaminski, Naftali, additional, Adegunsoye, Ayodeji, additional, Strek, Mary E., additional, Neighbors, Margaret, additional, Sheng, Xuting R., additional, Gudmundsson, Gunnar, additional, Gudnason, Vilmundur, additional, Hatabu, Hiroto, additional, Lederer, David J., additional, Manichaikul, Ani, additional, Newell, John D., additional, O’Connor, George T., additional, Ortega, Victor E., additional, Xu, Hanfei, additional, Fingerlin, Tasha E., additional, Bossé, Yohan, additional, Hao, Ke, additional, Joubert, Philippe, additional, Nickle, David C., additional, Sin, Don D., additional, Timens, Wim, additional, Furniss, Dominic, additional, Morris, Andrew P., additional, Zondervan, Krina T., additional, Hall, Ian P., additional, Sayers, Ian, additional, Tobin, Martin D., additional, Maher, Toby M., additional, Cho, Michael H., additional, Hunninghake, Gary M., additional, Schwartz, David A., additional, Yaspan, Brian L., additional, Molyneaux, Philip L., additional, Flores, Carlos, additional, Noth, Imre, additional, Jenkins, R. Gisli, additional, and Wain, Louise V., additional

Published
2020
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28. Pharmacologic Management of Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline

Author

Nici, Linda, Mammen, Manoj J; https://orcid.org/0000-0003-0343-3234, Charbek, Edward, Alexander, Paul E; https://orcid.org/0000-0003-3221-8875, Au, David H, Boyd, Cynthia M, Criner, Gerard J, Donaldson, Gavin C; https://orcid.org/0000-0002-5538-4190, Dreher, Michael, Fan, Vincent S, Gershon, Andrea S; https://orcid.org/0000-0002-0246-594X, Han, MeiLan K, Krishnan, Jerry A, Martinez, Fernando J, Meek, Paula M, Morgan, Michael, Polkey, Michael I; https://orcid.org/0000-0003-1243-8571, Puhan, Milo A, Sadatsafavi, Mohsen; https://orcid.org/0000-0002-0419-7862, Sin, Don D, Washko, George R, Wedzicha, Jadwiga A, Aaron, Shawn D; https://orcid.org/0000-0002-4762-3542, Nici, Linda, Mammen, Manoj J; https://orcid.org/0000-0003-0343-3234, Charbek, Edward, Alexander, Paul E; https://orcid.org/0000-0003-3221-8875, Au, David H, Boyd, Cynthia M, Criner, Gerard J, Donaldson, Gavin C; https://orcid.org/0000-0002-5538-4190, Dreher, Michael, Fan, Vincent S, Gershon, Andrea S; https://orcid.org/0000-0002-0246-594X, Han, MeiLan K, Krishnan, Jerry A, Martinez, Fernando J, Meek, Paula M, Morgan, Michael, Polkey, Michael I; https://orcid.org/0000-0003-1243-8571, Puhan, Milo A, Sadatsafavi, Mohsen; https://orcid.org/0000-0002-0419-7862, Sin, Don D, Washko, George R, Wedzicha, Jadwiga A, and Aaron, Shawn D; https://orcid.org/0000-0002-4762-3542

Published
2020

30. Effects of Inhaled Corticosteroid/Long-Acting β2-Agonist Combination on the Airway Microbiome of Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Clinical Trial (DISARM).

Author

Leitao Filho, Fernando Sergio, Hiroto Takiguchi, Kentaro Akata, Seung Won Ra, Ji-Yong Moon, Hyun Kuk Kim, Yuji Cho, Kei Yamasaki, Milne, Stephen, Yang, Julia, Cheng Wei Tony Yang, Xuan Li, Nislow, Corey, van Eeden, Stephan F., Shaipanich, Tawimas, Lam, Stephen, Leung, Janice M., Sin, Don D., Takiguchi, Hiroto, and Akata, Kentaro

Subjects
CORTICOSTEROIDS, OBSTRUCTIVE lung disease treatment, RANDOMIZED controlled trials, COMBINATION drug therapy, BRONCHOSCOPY, FORMOTEROL, ADRENERGIC beta agonists, RESEARCH, ADRENOCORTICAL hormones, RESEARCH methodology, CELL receptors, MEDICAL cooperation, EVALUATION research, TREATMENT effectiveness, COMPARATIVE studies, OBSTRUCTIVE lung diseases, RESEARCH funding, INHALATION administration, STATISTICAL sampling
Abstract

Rationale: Inhaled corticosteroids (ICS) are commonly prescribed with long-acting β2-agonists (LABA) in chronic obstructive pulmonary disease (COPD). To date, the effects of ICS therapy on the airway microbiome in COPD are unknown. Objectives: To determine the effects of ICS/LABA on the airway microbiome of patients with COPD. Methods: Clinically stable patients with COPD were enrolled into a 4-week run-in period during which ICS was discontinued and all participants were placed on formoterol (Form) 12 μg twice daily (BID). The participants were then randomized to budesonide/formoterol (Bud + Form; 400/12 μg BID), fluticasone/salmeterol (Flu + Salm; 250/50 μg BID), or formoterol only (12 μg BID) for 12 weeks. Participants underwent bronchoscopy before and after the 12-week treatment period. The primary endpoint was the comparison of changes in the airway microbiome over the trial period between the ICS/LABA and LABA-only groups. Measurements and Main Results: Sixty-three participants underwent randomization: Bud + Form (n = 20), Flu + Salm (n = 22), and Form (n = 21) groups; 56 subjects completed all visits. After the treatment period, changes in α-diversity were significantly different across groups, especially between Flu + Salm and Form groups (Δrichness: P = 0.02; ΔShannon index: P = 0.03). Longitudinal differential abundance analyses revealed more pronounced microbial shifts from baseline in the fluticasone (vs. budesonide or formoterol only) group. Conclusions: Fluticasone-based ICS/LABA therapy modifies the airway microbiome in COPD, leading to a relative reduction in α-diversity and a greater number of bacterial taxa changes. These data may have implications in patients who develop pneumonia on ICS. Clinical trial registered with www.clinicaltrials.gov (NCT02833480). [ABSTRACT FROM AUTHOR]

Published
2021
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31. Sputum Microbiome Is Associated with 1-Year Mortality after Chronic Obstructive Pulmonary Disease Hospitalizations

Author

Leitao Filho, Fernando Sergio, primary, Alotaibi, Nawaf M., additional, Ngan, David, additional, Tam, Sheena, additional, Yang, Julia, additional, Hollander, Zsuzsanna, additional, Chen, Virginia, additional, FitzGerald, J. Mark, additional, Nislow, Corey, additional, Leung, Janice M., additional, Man, S. F. Paul, additional, and Sin, Don D., additional

Published
2019
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32. Current Controversies in Chronic Obstructive Pulmonary Disease. A Report from the Global Initiative for Chronic Obstructive Lung Disease Scientific Committee

Author

Criner, Gerard J., primary, Martinez, Fernando J., additional, Aaron, Shawn, additional, Agusti, Alvar, additional, Anzueto, Antonio, additional, Bafadhel, Mona, additional, Barnes, Peter J., additional, Bourbeau, Jean, additional, Chen, Rongchang, additional, Ewig, Jeffrey, additional, Fabbri, Leonardo M., additional, Frith, Peter, additional, Halpin, David M. G., additional, Han, MeiLan, additional, Montes de Oca, Maria, additional, Nishimura, Masaharu, additional, O’Donnell, Denis, additional, Papi, Alberto, additional, Pavord, Ian, additional, Roche, Nicolas, additional, Rodriguez-Roisin, Roberto, additional, Salvi, Sundeep, additional, Singh, Dave, additional, Sin, Don D., additional, Stockley, Robert, additional, López Varela, M. Victorina, additional, Vestbo, Jørgen, additional, Vogelmeier, Claus F., additional, Washko, George, additional, Wedzicha, Jadwiga A., additional, and Celli, Bartolome R., additional

Published
2019
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33. Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement

Author

Wu, Ann Chen, primary, Kiley, James P., additional, Noel, Patricia J., additional, Amur, Shashi, additional, Burchard, Esteban G., additional, Clancy, John P., additional, Galanter, Joshua, additional, Inada, Maki, additional, Jones, Tiffanie K., additional, Kropski, Jonathan A., additional, Loyd, James E., additional, Nogee, Lawrence M., additional, Raby, Benjamin A., additional, Rogers, Angela J., additional, Schwartz, David A., additional, Sin, Don D., additional, Spira, Avrum, additional, Weiss, Scott T., additional, Young, Lisa R., additional, and Himes, Blanca E., additional

Published
2018
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38. Total Airway Count on Computed Tomography and the Risk of Chronic Obstructive Pulmonary Disease Progression. Findings from a Population-based Study

Author

Kirby, Miranda, Tanabe, Naoya, Tan, Wan C, Zhou, Guohai, Obeidat, Ma'en, Hague, Cameron J, Leipsic, Jonathon, Bourbeau, Jean, Sin, Don D, Hogg, James C, Coxson, Harvey O, Kirby, Miranda, Tanabe, Naoya, Tan, Wan C, Zhou, Guohai, Obeidat, Ma'en, Hague, Cameron J, Leipsic, Jonathon, Bourbeau, Jean, Sin, Don D, Hogg, James C, and Coxson, Harvey O

Abstract

RATIONALE Studies of excised lungs show that significant airway attrition in the "quiet" zone occurs early in chronic obstructive pulmonary disease (COPD). OBJECTIVES To determine if the total number of airways quantified in vivo using computed tomography (CT) reflects early airway-related disease changes and is associated with lung function decline independent of emphysema in COPD. METHODS Participants in the multicenter, population-based, longitudinal CanCOLD (Canadian Chronic Obstructive Lung Disease) study underwent inspiratory/expiratory CT at visit 1; spirometry was performed at four visits over 6 years. Emphysema was quantified as the CT inspiratory low-attenuation areas below -950 Hounsfield units. CT total airway count (TAC) was measured as well as airway inner diameter and wall area using anatomically equivalent airways. MEASUREMENTS AND MAIN RESULTS Participants included never-smokers (n = 286), smokers with normal spirometry at risk for COPD (n = 298), Global Initiative for Chronic Obstructive Lung Disease (GOLD) I COPD (n = 361), and GOLD II COPD (n = 239). TAC was significantly reduced by 19% in both GOLD I and GOLD II compared with never-smokers (P < 0.0001) and by 17% in both GOLD I and GOLD II compared with at-risk participants (P < 0.0001) after adjusting for low-attenuation areas below -950 Hounsfield units. Further analysis revealed parent airways with missing daughter branches had reduced inner diameters (P < 0.0001) and thinner walls (P < 0.0001) compared with those without missing daughter branches. Among all CT measures, TAC had the greatest influence on FEV (P < 0.0001), FEV/FVC (P < 0.0001), and bronchodilator responsiveness (P < 0.0001). TAC was independently associated with lung function decline (FEV, P = 0.02; FEV/FVC, P = 0.01). CONCLUSIONS TAC may reflect the airway-related disease changes that accumulate in the "quiet" zone in early/mild COPD, indicating that TAC acquired with commercially available software across various CT platform

Published
2018

39. Total Airway Count on Computed Tomography and the Risk of Chronic Obstructive Pulmonary Disease Progression. Findings from a Population-based Study

Author

Kirby, Miranda, primary, Tanabe, Naoya, additional, Tan, Wan C., additional, Zhou, Guohai, additional, Obeidat, Ma’en, additional, Hague, Cameron J., additional, Leipsic, Jonathon, additional, Bourbeau, Jean, additional, Sin, Don D., additional, Hogg, James C., additional, Coxson, Harvey O., additional, FitzGerald, J. Mark, additional, Marciniuk, D. D., additional, O’Donnell, D. E., additional, Hernandez, Paul, additional, Chapman, Kenneth R., additional, Cowie, Robert, additional, Aaron, Shawn, additional, Maltais, F., additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hamid, Qutayba, additional, Baglole, Carole, additional, Jabet, Carole, additional, Mancino, Palmina, additional, Fortier, Yvan, additional, Sin, Don, additional, Tam, Sheena, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Coxson, Harvey, additional, Kirby, Miranda, additional, Hague, Cameron, additional, Sadatsafavi, Mohsen, additional, To, Teresa, additional, Gershon, Andrea, additional, Li, Pei-Zhi, additional, Duquette, Jean-Francois, additional, Benedetti, Andrea, additional, Jensen, Denis, additional, O’Donnell, Denis, additional, Lo, Christine, additional, Cheng, Sarah, additional, Fung, Cindy, additional, Ferguson, Nancy, additional, Haynes, Nancy, additional, Chuang, Junior, additional, Li, Licong, additional, Bayat, Selva, additional, Wong, Amanda, additional, Alavi, Zoe, additional, Peng, Catherine, additional, Zhao, Bin, additional, Scott-Hsiung, Nathalie, additional, Nadirshaw, Tasha, additional, Latreille, David, additional, Baril, Jacinthe, additional, Labonte, Laura, additional, Chapman, Kenneth, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Cowie, Ann, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Maltais, Francois, additional, Brouillard, Cynthia, additional, Marciniuk, Darcy, additional, Clemens, Ron, additional, and Baran, Janet, additional

Published
2018
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40. Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers

Author

Obeidat, Ma’en, primary, Nie, Yunlong, additional, Fishbane, Nick, additional, Li, Xuan, additional, Bossé, Yohan, additional, Joubert, Philippe, additional, Nickle, David C., additional, Hao, Ke, additional, Postma, Dirkje S., additional, Timens, Wim, additional, Sze, Marc A., additional, Shannon, Casey P., additional, Hollander, Zsuzsanna, additional, Ng, Raymond T., additional, McManus, Bruce, additional, Miller, Bruce E., additional, Rennard, Stephen, additional, Spira, Avrum, additional, Hackett, Tillie-Louise, additional, Lam, Wan, additional, Lam, Stephen, additional, Faner, Rosa, additional, Agusti, Alvar, additional, Hogg, James C., additional, Sin, Don D., additional, and Paré, Peter D., additional

Published
2017
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42. American Thoracic Society/National Heart, Lung, and Blood Institute Asthma–Chronic Obstructive Pulmonary Disease Overlap Workshop Report

Author

Woodruff, Prescott G., primary, van den Berge, Maarten, additional, Boucher, Richard C., additional, Brightling, Christopher, additional, Burchard, Esteban G., additional, Christenson, Stephanie A., additional, Han, MeiLan K., additional, Holtzman, Michael J., additional, Kraft, Monica, additional, Lynch, David A., additional, Martinez, Fernando D., additional, Reddel, Helen K., additional, Sin, Don D., additional, Washko, George R., additional, Wenzel, Sally E., additional, Punturieri, Antonello, additional, Freemer, Michelle M., additional, and Wise, Robert A., additional

Published
2017
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43. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary

Author

Vogelmeier, Claus F., primary, Criner, Gerard J., additional, Martinez, Fernando J., additional, Anzueto, Antonio, additional, Barnes, Peter J., additional, Bourbeau, Jean, additional, Celli, Bartolome R., additional, Chen, Rongchang, additional, Decramer, Marc, additional, Fabbri, Leonardo M., additional, Frith, Peter, additional, Halpin, David M. G., additional, López Varela, M. Victorina, additional, Nishimura, Masaharu, additional, Roche, Nicolas, additional, Rodriguez-Roisin, Roberto, additional, Sin, Don D., additional, Singh, Dave, additional, Stockley, Robert, additional, Vestbo, Jørgen, additional, Wedzicha, Jadwiga A., additional, and Agustí, Alvar, additional

Published
2017
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44. Clotting in COVID-19: Is It All in the Genes?

Author

Cordero, Ana I. Hernandez and Sin, Don D.

Subjects
COVID-19 pandemic, FIBRINOGEN, BLOOD coagulation factors, CYTOKINE release syndrome, THROMBOEMBOLISM
Abstract

The article offers information on the impacts of the Covid-19 pandemic on the severe acute respiratory syndrome coronavirus-2. It mentions about the morbidity and mortality associated with the venous thromboembolism and Covid-19 pandemic. It discusses about the Covid-19–related cytokine storm that affect production of many proteins in the coagulation cascade such as fibrinogen.

Published
2021
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50. Novel genes for airway wall thickness identified with combined genome-wide association and expression analyses

Author

Dijkstra, Akkelies E., Postma, Dirkje S., van Ginneken, Bram, Wielpütz, Mark O., Schmidt, Michael, Becker, Nikolaus, Owsijewitsch, Michael, Kauczor, Hans Ulrich, De Koning, Harry J., Lammers, Jan W., Oudkerk, Matthijs, Brandsma, Corry Anke, Bossé, Yohan, Nickle, David C., Sin, Don D., Hiemstra, Pieter S., Wijmenga, Ciska, Smolonska, Joanna, Zanen, Pieter, Vonk, Judith M., Van Den Berge, Maarten, Boezen, H. Marike, Groen, Harry J M, Dijkstra, Akkelies E., Postma, Dirkje S., van Ginneken, Bram, Wielpütz, Mark O., Schmidt, Michael, Becker, Nikolaus, Owsijewitsch, Michael, Kauczor, Hans Ulrich, De Koning, Harry J., Lammers, Jan W., Oudkerk, Matthijs, Brandsma, Corry Anke, Bossé, Yohan, Nickle, David C., Sin, Don D., Hiemstra, Pieter S., Wijmenga, Ciska, Smolonska, Joanna, Zanen, Pieter, Vonk, Judith M., Van Den Berge, Maarten, Boezen, H. Marike, and Groen, Harry J M

Published
2015

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