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Your search keyword '"Weynand B"' showing total 9 results
Start Over Author "Weynand B" Publisher american thoracic society
9 results on '"Weynand B"'

1. Characterization of Small Airway Obstruction Diversity in COPD

Author

Geudens, V., primary, De Fays, C., additional, Willems, L., additional, Vermaut, A., additional, Aerts, G., additional, Kerckhof, P., additional, Goos, T., additional, Kaes, J., additional, Hooft, C., additional, Jin, X., additional, Beeckmans, H., additional, Khaled Mohamed Elm Mohamady, Y., additional, Aversa, L., additional, Vermant, M., additional, Gyselinck, I., additional, Verhaegen, J., additional, Van Slambrouck, J., additional, Aelbrecht, C., additional, Higham, A., additional, Cortesi, E., additional, Vanstapel, A., additional, McDonough, J.E., additional, Carlon, M.S., additional, Quarck, R., additional, Boone, M., additional, Dupont, L., additional, Weynand, B., additional, Pilette, C., additional, Van Raemdonck, D.E., additional, Ceulemans, L.J., additional, Hogg, J.C., additional, Hackett, T.-L., additional, Vos, R., additional, Wuyts, W.A., additional, Janssens, W., additional, Vanaudenaerde, B., additional, and Gayan-Ramirez, G., additional

Published
2024
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2. Expression of Exposed CLDN1 Is Linked to Early Pathological Lesions in Idiopathic Pulmonary Fibrosis

Author

Cortesi, E.E., primary, Anquetil, V., additional, Mcdonough, J.E., additional, Weynand, B., additional, Vanstapel, A., additional, Aelbrecht, C., additional, Aversa, L., additional, Aerts, G., additional, Geudens, V., additional, Xin, J., additional, Vermant, M., additional, Goos, T., additional, Gogaert, S., additional, Mohamady, Y.K.M.E., additional, Polini, E., additional, Toso, A., additional, El Saghire, H., additional, Meyer, M., additional, Baumert, T., additional, Toovey, S., additional, Manenti, L., additional, Iacone, R., additional, Christ, F., additional, Vanaudenaerde, B.M., additional, Teixeira, G., additional, De Sadeleer, L.J., additional, Wuyts, W.A., additional, and Carlon, M.S., additional

Published
2024
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3. Correspondence Between Audible Crackles and Lung Function Test Results

Author

Gogaert, S., primary, Goos, T., additional, Vermant, M., additional, Carlon, M.S., additional, De Crem, N., additional, De Sadeleer, L., additional, De Langhe, E., additional, Dubbeldam, A., additional, Vanaudenaerde, B., additional, Verschakelen, J., additional, Weynand, B., additional, Yserbyt, J., additional, Bertrand, A., additional, De Vos, M., additional, and Wuyts, W.A., additional

Published
2023
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4. Current Definitions of Progressive Pulmonary Fibrosis Might Be Inaccurate: Data From a Cohort of Patients With Rheumatoid Arthritis Associated Interstitial Lung Disease

Author

Vermant, M., primary, Goos, T., additional, Gogaert, S., additional, Carlon, M.S., additional, De Crem, N., additional, De Sadeleer, L., additional, De Langhe, E., additional, Dubbeldam, A., additional, Vanaudenaerde, B., additional, Verbeken, E., additional, Verschakelen, J., additional, Weynand, B., additional, Yserbyt, J., additional, Westhovens, R., additional, Verschueren, P., additional, and Wuyts, W.A., additional

Published
2023
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5. Intrafamilial Correlation and Variability in the Clinical Evolution of Pulmonary Fibrosis

Author

Goos, T., primary, Dubbeldam, A., additional, Vermant, M., additional, Gogaert, S., additional, De Sadeleer, L.J., additional, De Crem, N., additional, De Langhe, E., additional, Yserbyt, J., additional, Weynand, B., additional, Carlon, M.S., additional, Verschakelen, J., additional, Vermeer, S., additional, Verleden, S.E., additional, and Wuyts, W.A., additional

Published
2023
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9. Increased IgA Expression in Lung Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease.

Author

Ladjemi MZ, Martin C, Lecocq M, Detry B, Nana FA, Moulin C, Weynand B, Fregimilicka C, Bouzin C, Thurion P, Carlier F, Serré J, Gayan-Ramirez G, Delos M, Ocak S, Burgel PR, and Pilette C

Subjects
Acute Disease, Animals, B-Lymphocytes immunology, B-Lymphocytes metabolism, B-Lymphocytes pathology, Case-Control Studies, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Female, Fluorescent Antibody Technique, Humans, Interleukin-6 metabolism, Interleukins metabolism, Lung metabolism, Lung pathology, Male, Mice, Inbred C57BL, Middle Aged, Pulmonary Disease, Chronic Obstructive metabolism, Pulmonary Disease, Chronic Obstructive pathology, Real-Time Polymerase Chain Reaction, Smoking adverse effects, Smoking metabolism, Smoking pathology, Tertiary Lymphoid Structures metabolism, Tertiary Lymphoid Structures pathology, Immunoglobulin A metabolism, Lung immunology, Pulmonary Disease, Chronic Obstructive immunology, Tertiary Lymphoid Structures immunology
Abstract

Rationale: Accumulation of B cells and lymphoid follicles (LFs) has been described in chronic obstructive pulmonary disease (COPD) airways, but the functional status of lung B cells remains poorly known., Objectives: To characterize LFs for expression of IgA, the main mucosal antibody., Methods: The presence of B cells and LFs, including intrafollicular IgA expression, were determined in the lung from patients with COPD (n = 37) versus control subjects (n = 34) by immunohistochemistry. We also evaluated follicular IgA responses in the lungs from mice infected with Pseudomonas aeruginosa (PAO1) (n = 10 per group) and in smoking mice., Measurements and Main Results: Whereas in smokers B-cell numbers slightly increased, robust increases in B-cell and LF numbers (mainly in distal airways) were only observed in severe COPD. Most follicular B cells were IgM + (70-80%), but IgA + (and not IgG + ) B-cell numbers were increased in LFs from severe COPD compared with control subjects (twofold, 44.7% vs. 25.2%), and this was significant in distal but not proximal airways. Follicular IgA response was also observed in PAO1-infected mouse lungs, but not after smoke exposure. Moreover, follicular IgA expression associated with expression of IL-21, which was very potent to activate immunoglobulin production in vitro., Conclusions: This study shows that IgA production occurs in peribronchiolar LFs from severe COPD, where IL-21-producing T cells are present, and presumably represents a feature of exacerbated mucosal adaptive immune responses against microbial and/or self-antigens.

Published
2019
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