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Acne is one of the most common problem faced by today’s youth and is listed in eighth position in the prevalence. It is affecting almost 9.4% of the global population in the world. This skin ailment is mostly occurring in the teenagers. There is no medicine is available in the market which can cure acne. And also, there are some limitations to these available management therapies as well as side effects are associated with them. The overcome these drawbacks of the available therapies a herbal formulation can a better choice due to the easily availability, synergistic activity, better bioavailability and less side effects of phytoconstituents. For our study we have selected Raphanus sativum (Mulak), Piper nigrum (Marich) and Allium sativum (Rason) due to its uses and availability. We have estimated the chemical constituents and phytochemicals present in these plants and their activity against Propionibacterium acne. We have also prepared a formulation using all the three plants and tested them for their activity and drug release with the time. In the case of permeation study, after the 12 h study the percentage of drug release is calculated 76.65%. Finally, we are concluding that the prepared formulation and the herbs used both have the anti-acne activity and the skin penetration is good.