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TThe aim of the present study was to examine the mediation effect of patience in the relationship between coping styles and resilience in university students. The sample comprised 401 university students (290 females [72.3%] and 111 males [27.7%]). The Patience Scale, Coping Style Scale, and Brief Resilience Scale were employed in the study. SPSS and AMOS 21 were used for statistical analysis. According to the study findings, there were positive relationships between patience, resilience, and problem-focused coping styles. Emotion-focused coping styles were negatively associated with patience and resilience. The results of the mediating model showed that patience partially mediated the relationships between problem/emotion-focused coping styles and resilience. The researchers discussed the results and offered suggestions in light of the relevant literature.