1. Association of aortic stiffness with cognitive decline: Whitehall II longitudinal cohort study
- Author
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Carlos A. Valencia-Hernández, Marzieh Araghi, Ian B. Wilkinson, Mika Kivimäki, Eric J. Brunner, Martin J. Shipley, Archana Singh-Manoux, Carmel M. McEniery, Séverine Sabia, Apollo - University of Cambridge Repository, Wilkinson, Ian [0000-0001-6598-9399], and McEniery, Carmel [0000-0003-3636-0705]
- Subjects
Male ,medicine.medical_specialty ,Epidemiology ,Health Behavior ,Cognitive decline ,030204 cardiovascular system & hematology ,Pulse Wave Analysis ,Severity of Illness Index ,Pulse-wave velocity ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Cognition ,Vascular Stiffness ,Risk Factors ,Internal medicine ,Severity of illness ,medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Longitudinal Studies ,Prospective Studies ,Prospective cohort study ,Pulse wave velocity ,Aged ,Memory Disorders ,business.industry ,Arteries ,Middle Aged ,medicine.disease ,Neuro-Epidemiology ,Arterial stiffness ,Ageing ,Cardiology ,Aortic stiffness ,Female ,business ,030217 neurology & neurosurgery ,Cohort study - Abstract
Aortic stiffness is associated with an increased risk of cardio- and cerebrovascular disease and mortality and may increase risk of dementia. The aim of the present study is to examine the association between arterial stiffness and cognitive decline in a large prospective cohort study with three repeated cognitive assessment over 7 years of follow-up. Aortic pulse wave velocity (PWV) was measured among 4300 participants (mean ± standard deviation age 65.1 ± 5.2 years) in 2007–2009 and categorized based on the tertiles: (lowest third: 8.91 m/s). A global cognitive score was calculated in 2007–2009, 2012–2013, and 2015–2016 based on responses to memory, reasoning and fluency tests. Standardized global cognitive score (mean = 0, SD = 1) in highest third versus lowest third of PWV category was lower at baseline (− 0.12, 95% CI − 0.18, − 0.06). Accelerated 7-year cognitive decline was observed among individuals with the highest PWV [difference in 7-year cognitive change for highest third versus lowest third PWV: − 0.06, 95% CI − 0.11, − 0.01, P
- Published
- 2020
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