1. [Comparative study of the bronchodilator effect of inhaled fenoterol and aerosol salbutamol in patients with chronic bronchial asthma].
- Author
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Valdés Cuadrado L, Salgueiro Rodriguez M, Alvarez-Calderón Prat P, Arias Castells MR, Berdugo Oviedo M, Rabuñal Rey R, Ventosa Rial J, and Rodríguez Suarez JR
- Subjects
- Administration, Inhalation, Adult, Aerosols, Aged, Albuterol administration & dosage, Chronic Disease, Female, Fenoterol administration & dosage, Humans, Male, Middle Aged, Albuterol therapeutic use, Asthma drug therapy, Fenoterol therapeutic use
- Abstract
The bronchodilator effects of inhaled fenoterol (FI) and salbutamol aerosol (S) in 15 patients (8 male and 7 female with a median age of 44 +/- 13 years), diagnosed as suffering from asthma, were studied using spirometry (determining FEV1, FEF 25-75% and FVC) and flow volume curves (PEF, MEF 75% and MEF 25%). The mean theroric rate of FEV1, PEF, MEF 75% was defined as the theoric rate of the obstruction of central airways (PCA%) and the mean of FVC, FEF 25-75% and MEF 25% rates defined as the rate of the theoric obstruction of the peripheral airways (PPA%). Basal and 5, 15, 30, 60, 120, 240, 360, 480 minute determinations were done, after the administration of 200 mcg of S in the conventional way on two different days. The statistic study carried out using the "u" test of Mann-Whytney. No statistically significant differences in intensity, onset nor duration of the effect between both drugs were found. We concluded that FI is a drug of great utility in treatment of asthmatic patients and one which allowed, because of the easy inhaling technique, the use of beta 2 adrenergic drugs in a mayor number of patients who would otherwise have to resort to an alternative form of administration.
- Published
- 1989