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Your search keyword '"Nelyubina, Yulia V."' showing total 1 results
Start Over Author "Nelyubina, Yulia V." Publisher arkat usa inc.
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1. Optically pure trans-1-benzyl-4-aminopiperidin-3-ols. Synthesis and absolute configuration.

Author

Grishina, Galina V., Veselov, Ivan S., Nelyubina, Yulia V., and Surovaya, Anna N.

Subjects
*BENZYL compounds, *PIPERIDINE, *CHEMICAL synthesis, *CHIRAL drugs, *CHEMICAL precursors, *HYDROXYLATION
Abstract

Enantiomerically pure trans-(3R,4R)-4-aminopiperidin-3-ols, which are convenient precursors for making natural and synthetic aminohydroxylated piperidine alkaloid analogs, were efficiently synthesized through the reaction of enantiomerically pure (3R,4S)-3,4-epoxypiperidine with amines in the presence of LiClO4 in CH3CN at room temperature. The absolute stereochemistry of the resultant amino alcohols was determined by the stereochemical correlation method and single-crystal X-ray analysis. [ABSTRACT FROM AUTHOR]

Published
2011

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