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A series of new thiophene compounds 6a-6l was synthesized from the reactions of in situ generated cross-conjugated enaminothiones 2 and a-bromoketones/ethyl bromoacetate. Moreover, the synthesis of 1,3-thiazine 12 and functionalized thiopyran 18 heterocycles from the cycloaddition reactions of N,N'-bis[(dimethylamino)methylene]thiourea 9, is also described. Additionally, the binding conformations of these compounds 6a-6l and some anti-inflammatory drugs (NSAIDs) were determined by their docking in the active site of the Cyclooxygenase-2 (COX-2) enzyme. [ABSTRACT FROM AUTHOR]

A green, sustainable, and efficient one-pot, synthetic strategy for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones (DHQs) was developed. The ZnCl2/urea used as a deep eutectic solvent (DES) not only efficiently promoted the condensation between isatoic anhydride and benzaldehyde but unexpectedly acted as a nitrogen source (like ammonia) in situ to afford DHQs in excellent yields. This approach offers remarkable advantages, involving the triple role of DES in the synthesis of DHQs, atom-economical, green organocatalysts, metal-free conditions, cost-effectiveness, and tolerance to a range of functional groups. [ABSTRACT FROM AUTHOR]