Search

Your search keyword '"Hasebe, Masashi"' showing total 2 results
Start Over Author "Hasebe, Masashi" Publisher asian association for the study of diabetes and blackwell pub. asia
2 results on '"Hasebe, Masashi"'

1. Diabetic striatopathy: Hyperglycemic chorea/ballism successfully treated with L-dopa.

Author

Tsukaguchi R, Hasebe M, Shibue K, and Hamasaki A

Subjects
Humans, Female, Aged, Corpus Striatum pathology, Corpus Striatum diagnostic imaging, Diabetes Complications drug therapy, Dyskinesias drug therapy, Dyskinesias etiology, Treatment Outcome, Chorea drug therapy, Chorea etiology, Chorea complications, Hyperglycemia drug therapy, Hyperglycemia complications, Levodopa therapeutic use, Levodopa administration & dosage
Abstract

Diabetic striatopathy, a rare hyperglycemia complication, is characterized by chorea/ballism and striatal anomalies on neuroimaging, usually managed with glycemic control and haloperidol. However, practical strategies for haloperidol-resistant cases are scarce. We describe a 76-year-old Japanese woman with diabetic striatopathy who initially presented with polydipsia, polyuria, and lower-extremity weakness. Despite pronounced hyperglycemia (725 mg/dL), her blood glucose levels were reduced through saline infusion and intravenous insulin. Subsequently, she developed whole-body ballism concomitant with striatal hyperintensity on T1-weighted magnetic resonance imaging, which initially responded to haloperidol. Upon discontinuation of haloperidol, her symptoms relapsed and did not improve with the reintroduction of haloperidol. Dopamine transporter single photon emission computed tomography revealed diminished bilateral striatal uptake, suggesting presynaptic dopaminergic dysfunction. This finding prompted the initiation of L-dopa, which significantly improved her symptoms. This case underlines the need to consider presynaptic dopaminergic dysfunction in diabetic striatopathy patients unresponsive to standard treatments, highlighting the effectiveness of L-dopa in such scenarios., (© 2024 The Author(s). Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)

Published
2024
Full Text
View/download PDF

2. Plant sterol hyperabsorption caused by uncontrolled diabetes in a patient with a heterozygous ABCG5 variant.

Author

Hasebe M, Iwasaki Y, Keidai Y, Iwasaki K, Honjo S, and Hamasaki A

Subjects
Humans, Ezetimibe, ATP Binding Cassette Transporter, Subfamily G, Member 5 genetics, Lipoproteins genetics, Hypercholesterolemia, Phytosterols adverse effects, Phytosterols genetics, Lipid Metabolism, Inborn Errors complications, Lipid Metabolism, Inborn Errors drug therapy, Lipid Metabolism, Inborn Errors genetics, Intestinal Diseases complications, Intestinal Diseases genetics, Diabetes Mellitus
Abstract

Plant sterol intake is widely recommended for patients with cardiovascular risk factors based on the inhibitory effect on intestinal cholesterol absorption. Although plant sterols, once absorbed, can promote atherosclerosis, their intake is believed to be safe because of poor absorption, except in rare hyperabsorbers with homozygous ABCG5/8 mutations. We report a case of new-onset type 1 diabetes accompanied by hypercholesterolemia. At the initial presentation with diabetic ketoacidosis, the patient showed marked hypercholesterolemia. Whole-exome sequencing revealed a heterozygous pathogenic variant in ABCG5 (p.R419H). The initial serum plant sterol levels were markedly high (sitosterol 32.5 μg/mL, campesterol 66.0 μg/mL), close to the range observed in patients with homozygous ABCG5/8 mutations, which were largely reduced by insulin treatment without ezetimibe. The addition of ezetimibe normalized plant sterol levels. These findings provide the first evidence that uncontrolled diabetes plays a causal role in the pathogenesis of phytosterolemia., (© 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results