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&lt;b&gt;Background and Objective:&lt;/b&gt; Natural herbs and molecular therapy can be used to treat cervical cancer. The Myc and Wee1 control tumour cell fate and microenvironmental changes like angiogenesis activation and host immune response suppression. The study aims to know about the correlation of Myc and Wee1 expressions as a molecular therapy given by &lt;i&gt;Zanthoxylum acanthopodium&lt;/i&gt;. &lt;b&gt;Materials and Methods:&lt;/b&gt; There are five rat groups: Group K&lt;sup&gt;&lt;/sup&gt; is the untreated group, Group K&lt;sup&gt;+&lt;/sup&gt; is the rats injected with benzopyrene, Group P&lt;sub&gt;1&lt;/sub&gt; is the administration of &lt;i&gt;Zanthoxylum acanthopodium&lt;/i&gt; 100 mg kg&lt;sup&gt;1&lt;/sup&gt; b.wt., Group P&lt;sub&gt;2&lt;/sub&gt; is the administration of &lt;i&gt;Zanthoxylum acanthopodium&lt;/i&gt; 200 mg kg&lt;sup&gt;1&lt;/sup&gt; b.wt. and Group P&lt;sub&gt;3&lt;/sub&gt; is the administration of &lt;i&gt;Zanthoxylum acanthopodium&lt;/i&gt; 400 mg kg&lt;sup&gt;1&lt;/sup&gt; b.wt. The rats are dissected 30 days after receiving &lt;i&gt;Zanthoxylum acanthopodium&lt;/i&gt;. To stain the cervical tissues, immunohistochemistry is performed. &lt;b&gt;Results:&lt;/b&gt; &lt;i&gt;Zanthoxylum acanthopodium&lt;/i&gt; administration caused epithelial thickening and decreased Myc expression in previously uncontrolled carcinomas from untreated malignancies, which now slowed and stopped growing into the normal epithelium. Wee1 expression revealed that this herb could repair tissue by drastically reducing Wee1 expression at a dose of 100-400 mg kg&lt;sup&gt;1&lt;/sup&gt; b.wt. Similarly, at the highest dose, cervical carcinoma stops growing and the nucleus begins to form normally (p<0.01). &lt;b&gt;Conclusion:&lt;/b&gt; The higher Myc expression on andaliman administration in cervical carcinoma decreases Wee1 expression in cervical carcinoma so these two proteins have a strong and significant correlation. &lt;i&gt;Zanthoxylum acanthopodium&lt;/i&gt; can be administered at various dosages to lower the number of positive indexes of Myc and Wee1 expression in cervical carcinoma.

&lt;b&gt;Background and Objective:&lt;/b&gt; Cervical cancer is the leading cause of death for women in the world and Indonesia. This disease originates from a malignant tumour of squamous epithelial cells caused by infection with the Human Papilloma Virus (HPV). Antioxidants can reduce oxidative stress in and there are plants from Indonesia that have high antioxidants, namely andaliman (&lt;i&gt;Zanthoxylum acanthopodium&lt;/i&gt;). This study aimed to analyze the role of andaliman on PI3K and Wnt signalling in cervical cancer histology. &lt;b&gt;Materials and Methods:&lt;/b&gt; The study includes 5 treatments. The control group (K-), rats cancer model (K+), rats cancer model+the dose is 100 mg/b.wt. of ZAM (P&lt;sub&gt;1&lt;/sub&gt;), rats cancer model+the dose is 200 mg/b.wt. of ZAM (P&lt;sub&gt;2&lt;/sub&gt;) and rats cancer model+the dosage is 400 mg/b.wt. ZAM (P&lt;sub&gt;3&lt;/sub&gt;). On the 30th day after ZAM administration, the rats were dissected for the paraffin block and Wnt and PI3K immunohistochemical staining was prepared. &lt;b&gt;Results:&lt;/b&gt; There was a significant difference between all groups (p<0.001) in Wnt and PI3K expression. The real role of ZAM in cervical cancer tissue was seen at the highest ZAM dose (P&lt;sub&gt;3&lt;/sub&gt;). Irregular mucosal folds and stretched interstitial connective tissue in the K+ group can return to regularity and improve at the P&lt;sub&gt;3&lt;/sub&gt; dose. The administration of ZAM showed a significant difference in cervical tissue after benzopyrene injection. &lt;b&gt;Conclusion:&lt;/b&gt; Andaliman (&lt;i&gt;Zanthoxylum acanthopodium&lt;/i&gt;) extract increases PI3K expression through suppression of Wnt expression. It can be developed therapy molecularly to prevent cell growth into cancer.

&lt;b&gt;Background and Objective:&lt;/b&gt; Increased glucose levels in diabetes mellitus patients affect angiogenesis which triggers the duration of the wound to heal. &lt;i&gt;Rhodomyrtus tomentosa&lt;/i&gt; leaves (haramonting) and &lt;i&gt;Zanthoxylum acanthopodium &lt;/i&gt;fruits (andaliman) are an endemic plant with an antioxidant in Indonesia. This study was aimed to determine histology changes of diabetic wound healing in FGF expression by Nano herbal of haramonting and andaliman. &lt;b&gt;Materials and Methods:&lt;/b&gt; This study consisted of 4 groups for each treatment, K&lt;sub&gt;1&lt;/sub&gt;: Negative control, K&lt;sub&gt;2&lt;/sub&gt;: MEBO, K&lt;sub&gt;3&lt;/sub&gt;: Nano herbal of andaliman and K&lt;sub&gt;4&lt;/sub&gt;: Nano herbal of haramonting. The treatments were observed on days 0, 4, 8, 12 and 16. Diabetic model rats with alloxan injection (120 mg kg&lt;sup&gt;1&lt;/sup&gt;. IP) and rats were declared diabetes mellitus when blood glucose levels reached &lt;u&gt;>&lt;/u&gt;200 mg dL&lt;sup&gt;1&lt;/sup&gt;. The tissue was prepared on paraffin blocks and given Immunohistochemistry staining for FGF analysis. &lt;b&gt;Results:&lt;/b&gt; There was a significant difference between all groups (p<0.001) in FGF expression. The proliferation of fibroblasts and collagen was formed by administering nano herbal andaliman and haramonting in rat's skin. The proliferation of cells that occur in the injured skin layer indicates the compounds contained in the nano herbal haramonting and andaliman stimulate cell division and growth to form wound tissue. &lt;b&gt;Conclusion:&lt;/b&gt; Nano herbal andaliman and haramonting can be developed into herbs that can be used to treat wounds in diabetes. Another molecular gene analysis is required to get higher yields to further study for diabetic wounds against these two herbs.