1. Implication of polymorphisms in DNA repair genes in prognosis of hepatocellular carcinoma.
- Author
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Yue AM, Xie ZB, Guo SP, Wei QD, and Yang XW
- Subjects
- Adult, Female, Heterozygote, Homozygote, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Polymorphism, Single Nucleotide, Prognosis, Proportional Hazards Models, X-ray Repair Cross Complementing Protein 1, Carcinoma, Hepatocellular genetics, DNA-Binding Proteins genetics, Liver Neoplasms genetics, Xeroderma Pigmentosum Group D Protein genetics
- Abstract
XRCC1 genetic polymorphisms could be associated with increased risk of various cancer, including hepatocellular carcinoma (HCC), the fifth most common cancer. We here conducted a study to explore the role of selective SNPs of the XRCC1 and XPD genes in the prognosis of HCC. A total of 231 cases were collected, and genotyping of XRCC1 Arg194Trp, XRCC1 Arg399Gln, XPD Lys751Gln and XPD Asp312Asn was performed by duplex polymerase-chain-reaction with the confronting-two-pair primer method. Our findings indicated XRCC1 399Gln/Gln genotype was associated with a significant difference in the median survival time compared with patients carrying Arg/Trp and Arg/Arg genotypes, and individuals with XPD 751 Gln/ Gln genotype had a significantly greater survival time than patients carrying Lys/Lys and Lys/Gln genotypes. The Cox's regression analysis showed individuals carrying XRCC1 399Trp/Trp genotype had 0.55 fold risk of death from HCC than Arg/Arg genotype. Similarly, XPD 751Gln/Gln had a strong decreasein comparison to XPD Lys/Lys carriers with an HR of 0.34. These results suggest that polymorphisms in XRCC1 and XPD may have functional significance in the prognosis of HCC.
- Published
- 2013
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