1. Standard models of corneal injury using alkali-immersed filter discs.
- Author
-
Ormerod LD, Abelson MB, and Kenyon KR
- Subjects
- Animals, Cornea blood supply, Cornea pathology, Corneal Edema etiology, Corneal Ulcer etiology, Disease Models, Animal, Epithelium pathology, Filtration instrumentation, Keratitis etiology, Neovascularization, Pathologic pathology, Paper, Rabbits, Alkalies, Burns, Chemical complications, Corneal Injuries
- Abstract
Central corneal alkali burn injuries were induced in rabbits by applying five NaOH concentrations on uniformly soaked 7 mm filter paper discs. Clinical parameters were evaluated daily by microscopic examination and photography, and corneal myeloperoxidase levels were measured periodically. Satisfactory alkali burn models of corneal inflammation, vascularization and ulceration were developed by manipulating the alkali concentration.
- Published
- 1989