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Background: Endoscopic biopsy are easy, less time consuming and OPD side procedure where no general anaesthesia is required or hospitalization is needed, is required for confirmation of diagnosis which is impossible by FNAC. Endoscopic biopsy permits the correct identification of lesion and taking out the biopsy from the same site. Objectives: 1. To study the spectra of various histopathological lesions in GIT with the help of endoscopic biopsy. 2. To prove endoscopic biopsies as an efficient tool for reaching correct diagnosis. Methodology - Cross sectional study will be carried out from August 2018 to August 2021 AVBRH Sawangi, Wardha, Maharashtra. Patients with gastrointestinal symptoms undergoing endoscopic / colonoscopic examination. The biopsy specimen will be processed and then will be paraffin embedded. Each section will be stained with Hematoxylin and Eosin as per standard protocol and studied microscopically. 100 endoscopic biopsies were examined during the study period. Expected Results – Results will be evaluated after the completion of the study using SPSS VERSION 21. Conclusion- The conclusion will be based on the results of study. [ABSTRACT FROM AUTHOR]