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Objective: To evaluate correlation of Alberta Stroke Program Early CT Score (ASPECTS) and early and delay outcome measures among acute anterior ischemic stroke patients who presented within 48 hours of stroke onset. Methods: In a prospective cohort study, we recruited consecutive patients with acute middle cerebral artery (MCA) ischemic stroke who presented within 48 hours of stroke onset. All the patients were evaluated at admission (Glasgow Coma Scale - GCS and National Institute of Health Stroke Scale - NIHSS) at discharge (GCS, NIHSS, Barthel Index - BI and modified Rankin Scale - mRS) and at 3 months (BI and mRS). CT ASPECTS was calculated by two observers independently. We divided patients in to two groups with 'Better' and 'Worse' ASPECTS with score of 8-10 and 0-7 respectively and compared the primary and secondary stroke outcome measures. Results: Among 100 patients with acute MCA infarction (median age 55 yrs, 62 males), median ASPECTS scores had inter-rater reliability of 0.82. The mortality, GCS and NIHSS at discharge, and mRS and BI at 3 months are significantly better among patients with 'Better' compared to 'Worse' APSECTS. The hospital stay was shorter in patients with Better ASPCTS. Conclusion: In the setting of acute ischemic stroke, ASPECTS has good correlation with severity of stroke, and is strong predictor of early and delayed outcome in acute ischemic stroke. [ABSTRACT FROM AUTHOR]

We present here a 52 years old man with rapidly progressive cognitive decline and ataxia. Brain MRI showed confluent white matter changes and spinal MRI showed posterior column changes. The patient had vitamin B12 deficiency from pernicious anemia. There was clinical and radiological improvement by vitamin B12 replacement. There is no previous report of pernicious anemia causing reversible leukoencephalopathy and ataxia. [ABSTRACT FROM AUTHOR]

Mononeuropathy multiplex is a rare disorder associated with idiopathic thrombocytopenic purpura. Extrinsic compression due to hematoma, intraneural bleed and immune mediated nerve injury are reported mechanisms of neuropathy. We report of a case of a girl with recurrent idiopathic thrombocytopenic purpura with mononeuropathy multiplex, along with a brief review of the mechanism of neuropathies in asscociation with idiopathic thrombocytopenic purpura. [ABSTRACT FROM AUTHOR]

An abstract of the article "Changes in psychiatric comorbidity during early post-surgical period in patients operated for medically refractory epilepsy: a MINI based follow-up study," by Soaham Dilip Desai and colleagues is presented.