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Objective: To evaluate the impact of physical activity on the use of the health system and the quality of life in sedentary elderly., Methods: A prospective interventional study was carried out between March 2010 and February 2011 with 100 subjects (60-90 years of age,) divided into active group (AG) and control group (CG). During this period, AG performed physical exercise twice a week in 60-minute sessions and the CG remained sedentary with observation of their activities. Before and after the study, all subjects were clinically evaluated and completed a quality of life questionnaire., Results: Eighty-nine subjects (AG = 44; CG = 45) were analyzed. AG had fewer visits to emergency room (p = 0.0056), hospitalizations (p = 0.0011), length of hospital stay (p = 0.0012) and fewer subsidiary tests (p = 0.0236) compared to the CG. The quality of life score analyzed before and after physical activity increased in AG compared to CG (p < 0.0001) and among subjects in AG (p < 0.0001), with no change in the CG., Conclusion: The intervention of a physical activity program for sedentary elderly can contribute to reduce the use of the health system and improve the quality of life. Level of evidence II, Therapeutics Studies. Prospective comparative study. , Competing Interests: All authors declare no potential conflict of interest related to this article.