1. Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins among patients with very high risk of atherosclerotic cardiovascular disease in China (RWE-PCSK study)
- Author
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Xin-Ping Liu, Qing Li, Bin Shao, Jun Dai, Hong-Gang Nie, Meng Chai, Ming Gao, Dandan Li, Hong-Ying Yu, Hong-Liang Cong, Hui Zhang, Yundai Chen, Tie-Mei Zhang, Liang-Chen Zhao, Ji-Yi Zhao, Xiao-Jian Hong, Rong-Chong Huang, Yan-Qing Guo, Xiao-Yu Shen, Dong-Mei Wu, Zhi-Yong Yang, Jin Xia, Xiao-Qiang Cong, Jin-Cheng Guo, Jia-Yu Li, Hai-Qing Song, Yi-Jun Song, yuqi liu, Shuo Wang, Jia-Mei Liu, Ming-Qi Zheng, Fenshun Jia, Yu-Guo Liu, Li-Jun Wang, and Rongping Du
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Incidence (epidemiology) ,Confounding ,Percutaneous coronary intervention ,Clinical trial ,Internal medicine ,Conventional PCI ,Medicine ,business ,Prospective cohort study ,Very high risk ,Survival analysis - Abstract
Background The efficacy and safety of PCSK-9 inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China is unknown. Objective To describe the real world effectiveness of initiated with PCSK-9 inhibitors combined with statins compared with statins among patients with very high risk of ASCVD and underwent percutaneous coronary intervention (PCI). Methods This is a prospective study, enrolled patients from 32 hospitals between January to June 2019. The lipid control rate and incidence of cardiovascular events over 6 months were compared between two groups. A propensity score-matched analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for cardiovascular events. Results In a total of 3063 patients, 89.91% had received moderate or high-intensity statin therapy before PCI, but only 9.47% had LDL levels below 1.4mmol/L at baseline. In the PSM selected patients, LDL level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81% (P
- Published
- 2020
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