1. Leucocytes and Th-associated Cytokine Profile of HIV-Leishmaniasis Co-Infected Persons Attending Abuja Teaching Hospital, Nigeria
- Author
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Abubakar Umar Anka, Anthony Uchenna Emeribe, Habiba Yahaya Muhammad, Yusuf Mohammed, Adamu Babayo, Bamidele Soji Oderinde, Shamsuddeen Haruna, Halima Ali Shuwa, Abdurrahman Elfulaty Ahmad, Idris Nasir Abdullahi, and Hafeez Aderinsayo Adekola
- Subjects
Cellular immunity ,lcsh:R5-920 ,biology ,business.industry ,medicine.medical_treatment ,Leishmania donovani ,Immunosuppression ,Leishmaniasis ,General Medicine ,Eosinophil ,biology.organism_classification ,medicine.disease ,Leishmania ,medicine.anatomical_structure ,Acquired immunodeficiency syndrome (AIDS) ,Immunology ,medicine ,biology.protein ,Original Article ,Antibody ,business ,lcsh:Medicine (General) - Abstract
OBJECTIVE: T-helper cells (Th)-1& -2 cytokines homeostasis control or predict clinical outcome of infected persons, especially those with HIV /AIDS. This case-control study evaluated the leucocytes differentials, TNF-alpha, interleukin (IL)-2 and -10 levels among HIV infected persons with serological evidence of leishmaniasis attending University of Abuja Teaching Hospital, Nigeria MATERIALS AND METHODS: Blood samples from 28 HIV infected persons who had Leishmania donovani rK39 and Immunoglobulin-G (IgG) positive (group 1), 30 age- & -sex matched HIV infected persons without Leishmania antibodies (group 2) and 30 apparently healthy persons without HIV and Leishmania antibodies (group 3). Full blood counts, TNF alpha, IL-2 and -10 levels were analyzed using automated hematology analyzer and ELISA, respectively. Structured questionnaires were used to collate biodata and clinical presentations of participants. RESULTS: Ten (35.7%) participants in group 1 were on ART, 15 (50%) in group 2 were on ART, while group 3 were ART naïve. There were significantly higher values in basophil (4.4±2.5%) and eosinophil counts (12.9±3.8%) in HIV/leishmania coinfected persons (p
- Published
- 2020