1. Prognostic value of the 2017 World Health Organization Classification System for gastric neuroendocrine tumors: A single-center experience
- Author
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Saadettin Kilickap, Olcay Kurtulan, Suayib Yalcin, Yusuf Karakas, Sahin Lacin, Cenk Sokmensuer, Ece Esin, and Veli Sunar
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Neuroendocrine tumors ,World Health Organization ,Single Center ,World health ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,In patient ,Progression-free survival ,Radical surgery ,Pathological ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Incidence (epidemiology) ,Gastroenterology ,Middle Aged ,Prognosis ,medicine.disease ,Survival Rate ,Neuroendocrine Tumors ,030220 oncology & carcinogenesis ,Original Article ,Female ,030211 gastroenterology & hepatology ,Neoplasm Grading ,business - Abstract
BACKGROUND/AIMS: Gastric neuroendocrine tumors (G-NETs) are rare tumors, but their incidence is gradually increasing. Despite the existence of many classification systems, determining prognosis and planning treatment in patients with G-NETs remains a clinical challenge. In this study, the prognostic value of the World Health Organization (WHO) 2017 grading system and the effect of surgery on survival in low grade neuroendocrine tumors were investigated. MATERIALS AND METHODS: G-NETs who were diagnosed between January 2000 and May 2017 were included in the study. Patients’ demographic characteristics, treatment details, and survival data were obtained from medical charts. Pathological samples were re-classified according to the WHO 2017 grading system. RESULTS: Of the total 94 evaluated patients, 50 (53.2%) were classified with G1 NETs, 37(39.4%) with G2 NETs, 4(4.2%) with well-differentiated G3 NETs, and the remaining 3 patients with poorly differentiated G3 neuroendocrine carcinoma (NEC). The median follow-up time was 83.2 months. There was a statistically significant difference in 5-year progression free survival (PFS) between G1 tumors (100%) and G2 tumors (76%) (p
- Published
- 2020
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