1. Bone marrow involvement: Atypical presentation of early-onset childhood sarcoidosis.
- Author
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Meshram, Rajkumar M., Gajimwar, Vishal S., Gholap, Siddhant, and Jhanwar, Madhuri
- Subjects
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SARCOIDOSIS , *MULTINUCLEATED giant cells , *BONE marrow , *ETIOLOGY of diseases , *UVEITIS , *EOSINOPHILS - Abstract
Childhood sarcoidosis is a chronic multisystemic, non-caseating granulomatous disease of unknown etiology. Early-onset disease classically presents with a triad of skin rash, uveitis, and arthritis, but bone marrow involvement is rare. We report a 9-1/2- year old Indian female child who presented with bleeding manifestation, skin rash, uveitis, and arthritis. Bone marrow biopsy showed multiple non-necrotizing granulomas comprising epithelioid cells, mature lymphocytes, and multinucleated giant cells with few eosinophils in the background, with negative staining for acid-fast bacilli or fungi. She was treated successfully with oral prednisolone. This is the first report of an early-onset childhood sarcoidosis with bone marrow involvement from India. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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